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Biomedical subjects

A Chopra

Publications and source records attributed to A Chopra.

90 records · Page 5Linked to original sources
PubMed1981

Lipids of dermatophytes.

This investigation deals with phosphatides and fatty acid content of Epidermophyton floccosum, Microsporum cookie and Trichophyton mentagrophytes during different phases of growth. Total phosphatide content of these dermatophytes decreased with age, which was reflected in constituent major phosphatides. The zwitterionic and anionic phospholipids tended to maintain a constant ratio. Short chain fatty acids increased significantly with age in E. floccosum whereas these fatty acids represented a minor fraction of the total fatty acids in M. cookie and T. mentagrophytes. The ratio of saturated to unsaturated fatty acids increased 4-fold during growth in E. floccosum, whereas this increase was marginal in M. cookie. This ratio decreased in T. mentagrophytes.

Arthrodermataceae↗
PubMed1980

Hydronephrosis in children: narrowing the differential diagnosis with ultrasound.

Twenty patients with hydronephrosis in whom examination with ultrasound was helpful in defining the extent of dilation of the collecting system are presented. Thirteen patients had hydronephrosis due to obstruction at the ureteropelvic junction, six had obstruction of the ureterovesical junction from various causes, and one had massive bilateral vesicoureteral reflux. The diagnosis of high ureteral obstruction as opposed to obstruction or reflux at the ureterovesical junction was based on visualizing a dilated ureter in the later two groups.

Child↗
PubMedDate not supplied

Biochemical characterization of ketosis-resistant young diabetics of northern India. In vivo effects of i.v. glucose, s.c. epinephrine and i.v. glucagon and in vitro effects of anti-insulin serum on adipose tissue lipolysis.

Epinephrine (10 micrograms/kg body weight) s.c., glucagon (1 microgram/kg body weight) i.v. and glucose (0.5 g/kg body weight) i.v. were injected in groups of ketosis-prone young diabetics, ketosis-resistant young diabetics, maturity-onset diabetics, young and mature controls, each group comprising 8 subjects. Samples were drawn at timed intervals and analyzed for glucose, FFA, acetone, citrate and plasma free insulin. FFA and glycerol release by the adipose tissue in vitro was studied in 6 of each of the following groups: young diabetics and young controls in the presence of norepinephrine, anti-insulin serum or both. Failure of the adipose tissue of ketosis-resistant young diabetics to respond to lipolytic and ketogenic hormones has been suggested by others as the basis for the clinically observed resistance to ketoacidosis. The present data do not confirm any failure of the liver or adipose tissue to respond to glucagon, epinephrine or norepinephrine in these diabetics. The ketosis-resistant young diabetics have some endogenous insulin secretory capacity still preserved as evident from their basal and post-glucose free insulin levels and effects of anti-insulin serum on in vitro lipolysis by their adipose tissues. The available endogenous insulin though adequate in preventing excessive lipolysis and ketogenesis, appears insufficient to check hyperglycemia.

Adipose Tissue↗
PubMedDate not supplied

Resolution of caffeine-induced complex dysrhythmia with procainamide therapy.

A case report of a 38-year-old male who ingested 20 gm of caffeine is presented. The patient exhibited clinical and laboratory evidence of caffeine toxicity. Cardiac monitoring revealed a chaotic rhythm with variable supraventricular and ventricular dysrhythmias without hemodynamic compromise. Procainamide was used effectively to convert this complex dysrhythmia. The mechanisms, manifestations, and therapy of caffeine toxicity are reviewed.

Adult↗
PubMedDate not supplied

Heliox does not improve FEV1 in acute asthma patients.

Thirteen patients with an acute exacerbation of asthma and pre-treatment FEV1 between 20%-60% of predicted were tested to determine whether a blend of 70:30, helium:oxygen (heliox) improved FEV1. No pretreatment with bronchodilators occurred. The change in absolute and predicted FEV1 was measured after five minutes of breathing heliox. It was found that the absolute FEV1 during heliox was not significantly different from the absolute FEV1 before heliox. The difference between the absolute FEV1 during and before heliox was found to be -0.04 l. The percent predicted FEV1 during heliox was 40.8% +/- 13.0% vs. 41.5% +/- 11.9% before heliox. The difference between the percent predicted FEV1 during and before heliox was found to be -0.7%. We conclude that 70:30 heliox does not improve FEV1 in these patients.

Acute Disease↗
PubMedDate not supplied

Post-infarction ischaemic mitral regurgitation: what determines the outcome.

Ischaemic mitral regurgitation is an important determinant of survival in patients with coronary artery disease. A retrospective analysis was performed to evaluate the overall outcome and its determinants in patients with ischaemic mitral regurgitation. Over a period of 10 years, 72 patients underwent operations for mitral regurgitation of ischaemic origin. Age ranged from 37 to 68 years (mean 54.6 +/- 10.4 years), and 62 (86.1%) were male. Thirteen (18%) patients had acute and 59 (82%) had chronic ischaemic mitral regurgitation. Twenty-one patients were in New York Heart Association class II, 32 in class III and 19 in class IV. Moderate to severe left ventricular dysfunction was present in 42 patients. Valve prolapse was present in 35 (48.6%) patients and restricted leaflet motion secondary to myocardial dysfunction was present in 37 (51.4%) patients. All the patients were operated using standard cardiopulmonary bypass technique. Mitral valve was replaced in 33 patients and repaired in 39. Repair included a combination of techniques: chordal transposition (n = 2), chordal shortening (n = 18), leaflet resection (n = 2), posterior collar annuloplasty (n = 35) and annuloplasty with flexible Duran's ring (n = 3). Operative mortality was 18.1 percent (13/72). Low cardiac output was the cause of death in the majority (n = 10). Acute presentation and presence of restricted leaflet motion were the significant predictors of early mortality. Follow-up ranged from 3 to 84 months (mean 41.6 +/- 10.2 months). Late mortality was 46.2 percent. Actuarial survival in operative survivors at five years was 44.4 +/- 8.8 percent. To conclude, ischaemic mitral regurgitation carries a poor early and late outcome, with left ventricular dysfunction and presence of restricted leaflet motion being important contributors to it. In addition, acute presentation also reflects greater early mortality.

Adult↗
PubMedDate not supplied

Percutaneous transseptal mitral commissurotomy in pregnant women with critical mitral stenosis.

BACKGROUND: Percutaneous transseptal mitral commissurotomy has been successfully performed in selected pregnant patients with severe symptomatic mitral stenosis. Its safety and efficacy needs to be evaluated in a large number of cases. METHODS AND RESULTS: Percutaneous transseptal mitral commissurotomy was performed in 85 severely symptomatic (New York Heart Association functional class III or IV) pregnant women aged 22.7+/-4.1 years (range 18-39 years) with critical mitral stenosis at 24.8+/-4.7 weeks (range 20-34 weeks) of gestation. Percutaneous valvotomy was performed using a flow-guided Inoue balloon in all the patients. The procedure was considered successful in 80 (94%) patients. The hemodynamic mean end-diastolic gradient decreased from 26.7+/-6.8 mm Hg (range 16-35 mmHg) to 4.5+/-3.8 mmHg (range 0-14 mmHg) (p<0.001). The mean diastolic gradient decreased from 29.1+/-9.1 mmHg (range 18-38 mmHg) to 7.2+/-4.1 mmHg (range 4.1-18 mmHg) (p<0.001). The mean mitral valve area assessed by echocardiography increased from 0.75+/-0.5 cm2 (range 0.4-1.0 cm2) to 2.0+/-0.5 (range 1.0-2.7 cm2) (p<0.001). The mean fluoroscopy time was 3.6+/-3.2 minutes. The results of the mitral valvotomy were considered suboptimal in 4 patients. Mitral regurgitation increased by 1 grade in 16 patients and more than 2 grades in 2 patients. One patient developed pericardial tamponade during the procedure and was managed by catheter drainage. Percutaneous mitral valve dilatation was then successfully performed in this patient. No fetal abortion occurred after the procedure. CONCLUSIONS: The results of this study indicate that percutaneous transseptal mitral commissurotomy is a safe and effective procedure for severe symptomatic mitral stenosis in pregnancy.

Adolescent↗
PubMedDate not supplied

Acute haemodynamic effects of nicorandil in patients with chronic severe regurgitant valvular lesions.

The haemodynamic effects of nicorandil, a new balanced vasodilator exhibiting nitrate-like as well as potassium-channel opening activity in patients with chronic severe valvular lesions have not been reported. We studied the acute effect of nicorandil on haemodynamics in 12 stable patients (6 males, 6 females; mean age 23.5 +/- 4.6 years) with chronic severe valvular regurgitation (8 mitral, 4 aortic). All patients were studied in resting, supine and fasting states. All cardioactive drugs were withdrawn five days prior to the study. Intra-arterial line was placed and thermodilution catheter was positioned in the pulmonary artery. Haemodynamic parameters recorded at baseline and at 30, 60, 90 and 120 minutes following a single oral dose of 20 mg nicorandil revealed no significant change in the heart rate while systemic pressures showed a small decline (p < 0.05). There was significant reduction in systolic, diastolic and mean pulmonary artery pressures (p < 0.001). The mean cardiac index increased from 3.16 L/min/m2 at baseline to 3.77 L/min/m2 at 60 minutes. Both the pulmonary and systemic vascular resistance indices reduced significantly, the peak fall being 18 percent and 29 percent, respectively. Maximal changes were observed at 60 to 90 minutes following administration of nicorandil. No adverse effect of nicorandil occurred during the study. We conclude that nicorandil has a favourable acute haemodynamic effect in patients with chronic severe valve regurgitation. Its long-term use in valvular lesions should be explored further.

Administration, Oral↗