Biomedical subjects

A Chodera

Publications and source records attributed to A Chodera.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Pharmacodynamics and pharmacokinetics of psycholeptic drugs in the course of radiation disease.

The effect of metanabol (1 mg per kg) applicated to rats during 10 days before irradiation (600 R) on pharmacodynamics and some indices of thioridazine kinetics was investigated. It was found that the increased cataleptic action of thioridazine (20 mg per kg), during radiation disease was inhibited ater metanabol premedication. The protective effect of metanabol was found to be due to shortening of the half-life time of thioridazine (from 5.5 h in irradiated to 2.38 h in irradiated premedicated animals) as well as to lowering of thioridazine content in the brain tissue.

Animals↗

PubMedDate not supplied

Anxiolytic and memory improving activity of fluoxetine.

The anxiolytic and memory improving effects of fluoxetine, a new antidepressant drug, were investigated in rats. Anxiolytic activity was examined using Crowley's "two compartment exploratory test". Memory was assayed in the response passive avoidance test (RPAT) and labyrinth test. Wistar rats were used in all experiments. They were given fluoxetine hydrochloride (5 mg/kg po) and scopolamine hydrobromide at the dose of 0.5 mg/kg, sc. It was found that the drug has a high anxiolytic activity after the first administration. Thereafter however, the anxiolytic effect gradually decreased and 28 days later it was no longer present. In memory testing experiments (RPAT and labyrinth test) fluoxetine improved the performance of memory task and up to 14 days there were no signs of tolerance development. The authors discuss the possibility of involvement of the anxiolytic and memory improving effects of fluoxetine in the antidepressant action of the drug.

Animals↗

PubMedDate not supplied

Pharmacological aspects of withdrawal from certain benzodiazepines.

The aim of the study was to investigate, if the occurrence of benzodiazepine withdrawal syndrome is connected with benzodiazepine receptors, their down-regulation as well as with the number of drug applications. The results showed that symptoms of withdrawal measured by the anxiolytic and sedative effects occurred after chronic treatment with alprazolam for 14-21 days and after chlordiazepoxide daily administration for 35 days, and in both cases, after 48-hour abstinence period. In the same experimental design Ro 15-1788 administered at a dose of 10 mg/kg i.p. 25 min prior to examination prevented the development of the anxiogenic and locomotor stimulating withdrawal response in these rats. The symptoms of withdrawal measured by the sedative and anxiolytic effects were accompanied by a down-regulation of benzodiazepine receptors. It can be assumed that the process of withdrawal from benzodiazepines is related to benzodiazepine receptors, and that the number of drug applications plays an important role.

Animals↗