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Biomedical subjects

A Chodera

Publications and source records attributed to A Chodera.

At least 37 records · Page 2Linked to original sources
PubMed1981

Interaction of parachlorophenylalanine, mianserine and danitracen with amphetamine.

Three antiserotonin compounds, p-chlorphenylalanine, mianserine and danitracen, were investigated for their influence on amphetamine stereotypy in correlation with concentration of this amine in blood serum and brain tissue. A positive correlation (decrease of stereotypy as well as the concentration of amphetamine in serum and brain) was found only for danitracen. p-Chlorphenylalanine and mianserine premedication decreased serum and brain tissue concentration of amphetamine, but enhanced amphetamine stereotypy effect. It is assumed that in the mixed pharmacodynamic-pharmacokinetic interaction in the case of mianserine and p-chlorphenylalanine the pharmacodynamic component (inhibition of the serotoninergic system in CNS) prevails, whereas in the case of danitracen the pharmacokinetic effect was superior.

Amphetamine↗
PubMed1980

In vitro studies on the cytostatic activity of propolis extracts.

Extracts from propolis have been investigated for cytostatic activity in vitro, by method of tissue culture on human KB and HeLa cell lines. Diethyl ether extract (DEEP) sowed the greatest activity and therefore it was further fractionated. Secondary DEEP fractions obtained by extraction with BuOH (ED50 = 2.6 micrograms/ml) and AcOEt (ED50 = 3.3 micrograms/ml) have been qualified to further in vivo studies.

Cell Division↗
PubMed1979

The effect of tricyclic antidepressants (TA) on the circulatory system in primary arterial hypertension.

The cardio-vascular reactions after i.m. application of 0.4 mg/kg of TA (imipramine, amitryptyline and nortryptyline) were compared in normotonics and patients suffering from essential hypertonia. It was found, that systolic blood pressure decreased significantly after the drugs only in hypertonic patients, whereas diastolic blood pressure fall was marked more in the normotonic group. In both groups, no apparent changes in heart action were noticed after the drugs. The TA caused a stronger increase of urine excretion of NE, E, VMA and NMN and MN in hypertonics than in normotonics.

Amitriptyline↗
PubMed1978

Some aspects of pharmacokinetic and biotransformation differences in humans and mammal animals.

The erroneous tendency to set pharmacokinetics and biotransformation of drugs in man against results obtained in animals as a different homogenous group is discussed. Species differences have mainly a quantitative character, such as the body weight to surface ratio, organ weight to body weight ratio, presence of differing fat deposits, etc. Qualitative differences are not so common. The great importance of a better knowledge of these problems for the prediction of drug effects in man from results obtained in animals is emphasized.

Adult↗
PubMed1976

The influence of premedication with 6-OH-dopamine and long-term administration of thymoanaleptics on development of experimental arterial hypertension.

Administration of 6-OH-DA into the lateral cerebral ventricle did not prevent development of hypertension or influence the effects of administration of tricyclic antidepressant drugs (TA). Injection os 6-OH-DA intraperitoneally prevented development of hypertension, and TA apparently protected against the consequences of administration of 6-OH-DA.

Animals↗
PubMed1975

Sesquiterpene lactones XVII. Cytostatic and pharmacological activity.

Of four lactones studied in the systems Sa-180, EAC and L-1210, two compounds: alatolide, (ALA) and eupatoriopicrin (EUPP), according to the criteria of CCNSC, showed high cytostatic activity, and ursiniolide A (URSA) "moderate" cytostatic activity against at least one type of transplantable tumor. Two compounds were selected for further confirmatory investigation: EUPP, which gave 92% inhibition of EAC and 60% increase in survival of animals bearing Leukemia L-1210; and ALA, which gave 96% inhibition of growth of EAC.

Animals↗
PubMed1975

[Postsynaptic attack of tricyclic antidepressive agents in the circulatory system].

Tricyclic antidepressives (TA) exert differential effects on the circulatory system, though all of them have one principle in common: inhibition of back resorption of noradrenaline in the adrenergic synapses. Of more importance, however, seems to be the dose rather than the type of substance used. Smaller doses were found to potentiate the pressoric effects of noradrenaline, while higher doses frequently had an inhibitory action. In rats pretreated with 6-OH-dopamine, only an inhibitory action has been established. It is concluded that the TA must have a postsynaptic influence that becomes effective either through the membrane receptors and/or other factors within the cell.

Amitriptyline↗