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Biomedical subjects

A Chechick

Publications and source records attributed to A Chechick.

16 recordsLinked to original sources
PubMed1993

Total hip replacement in familial Mediterranean fever.

Familial Mediterranean fever (FMF) is a hereditary disorder affecting people of Mediterranean stock, mainly Sephardic Jews and Armenians. It is characterized by attacks of arthritis, either short, self-limited episodes typically lasting 72 hours or protracted attacks lasting from two weeks to one year. The latter form affects mainly the large joints of the lower limb. The hip joint is the most vulnerable and likely to be affected by the protracted attacks, which may result in destruction of the articular cartilage and, in some cases, aseptic necrosis of the femoral head. Eighteen FMF patients (19-52 years) underwent 22 total hip replacements between 1971 and 1985 at our hospital. Six of the 18 initial prostheses experienced aseptic loosening. This relatively high incidence led us to recommend implantation of cementless hip prostheses following meticulous synovectomy as the treatment of choice. The results of these surgeries and the uniqueness of total hip replacement in FMF patients are presented here and discussed.

Adult↗
PubMed1990

Approaches to senior care #10. Recurrent dislocation of the shoulder in an elderly patient.

A case in which 23 recurrent episodes of anterior dislocation of the shoulder occurred in a 76-year-old woman is presented. Du Toit and Roux staple capsulorrhaphy was used to achieve a stable, functioning shoulder. Recurrent dislocation of the shoulder is a problem of youth. Peak incidence occurs at age 20, after age 70, the incidence of recurrent dislocation of the shoulder is extremely low. The surgical treatment of a 76-year-old woman, who suffered 23 documented anterior dislocations of the right shoulder, is discussed and reviewed.

Aged↗
PubMed1988

Hemangioma of the thoracic spine involving multiple adjacent levels: case report.

An unusual case of hemangioma involving three adjacent dorsal vertebrae with a clinical picture of progressive paraparesis is presented. Radiological verification of the lesion can be expected if possible, using plain X-Rays, tomography, CT scan and myelography. The roentgenographic appearances of vertebral hemangioma were characteristic, but only CT revealed the true extent of the disease. Reports of such a case have appeared infrequently in the literature. [Karshner 1936, Bailey 1955, Reeves 1964, Robbins 1958].

Aged↗
PubMed1987

A new patella syndrome.

A 14-year-old boy is reported with bilateral hypoplastic patellae and multiple congenital skeletal anomalies. Since this constellation of bony malformations has not been described previously, we believe this represents a new syndrome most probably of genetic etiology.

Bone and Bones↗
PubMed1983

Lower limb injuries in parachuting.

Parachuting injuries commonly result from inaccurately performed landing. Alteration of the vertical force absorption pattern to a rotational one is suggested as their major cause. Special attention to the flexed body position and adduction of the lower limbs while gliding and landing can prevent those injuries.

Adult↗
PubMed1982

Brown-Séquard syndrome associated with brachial plexus injury in neck trauma.

A case of adult cervical trauma that resulted in a clinical picture of Brown-Séquard syndrome and unilateral brachial plexus injury is presented. Rotational hyperflexion of the cervical spine is thought to have resulted in subluxation of C5-6 with root avulsions, leading to this unusual combination of findings.

Brachial Plexus↗
PubMed1982

In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives.

Pseudomonas aeruginosa elastase is a zinc metalloendopeptidase, probably responsible for the tissue destruction observed during infections with this organism. The elastase of a virulent Pseudomonas aeruginosa strain (Habs serotype 1) was isolated and found to have a molecular weight of 35,000; it readily degraded elastin and cartilage proteoglycans. A series of amino acid and peptide derivatives containing the metal-chelating moieties hydroxamate, phosphoryl, or thiol were synthesized and tested as potential inhibitors of the enzyme. Inhibition constants (K(i)s) for the compounds were determined with the chromophoric substrate furylacryloyl-glycyl-l-leucyl-l-alanine. The hydroxamic acid derivatives of benzyloxycarbonyl-glycine, benzyloxycarbonyl-l-leucine and benzyloxycarbonyl-l-phenylalanine had inhibition constants in the range of 11 to 28 muM. The 2-mercaptoacetyl derivatives of l-leucyl-d-phenylalanine and l-leucyl-l-phenylalanine had K(i) values of 34 and 1.5 muM, respectively, demonstrating the stereospecificity of the inhibition. The most potent inhibitors tested were 2- mercaptoacetyl-l-phenylalanyl-l-leucine and phosphoryl-l-leucyl-l-phenylala-nine (K(i) = 0.2 muM). Similar compounds lacking the metal-chelating moiety were about 3 orders of magnitude poorer inhibitors. When the inhibition of the enzyme activity towards azocasein, elastin, or cartilage was examined, inhibitor concentrations approximately 50-fold higher than the respective K(i)s were required to obtain 60 to 90% inhibition. Virtually complete inhibition was achieved with these substrates at inhibitor concentrations 500-fold higher than the respective K(i)s (0.1 to 14 mM). Although, 2-mercaptoacetyl-l-phenylalanyl-l-leucine and phosphoryl-l-leucyl-l-phenylalanine exhibited the same affinity to the enzyme, the latter was inferior in inhibiting cartilage proteoglycan degradation. 2-Mercaptoacetyl-l-phenylalanyl-l-leucine represents a class of potent elastase inhibitors that might prove useful in the management of P. aeruginosa infections.

Cartilage↗
PubMed1981

[Eosinophilic granuloma affecting long bones in children].

Destructive bone lesions in long bones associated with onion like periosteal reaction was found in two girls. Diagnosis of Ewing sarcoma was followed by bone biopsy which indicated eosinophilic granuloma. The radiological appearances of osteomyelitis, tuberculosis, congenital syphilis, Caffey's disease and metastases of neuroblastoma are similar. Bone biopsy is mandatory for correct diagnosis.

Biopsy↗
PubMed1981

Subtalar dislocations.

Severe plantarflexion of the foot associated with adduction and supination resulted in medial subtalar dislocation in three patients. Closed manipulation in two patients and open reduction in one restored normal anatomy of the foot, with no complications in a follow-up of 1 to 2 years.

Accidents, Home↗
PubMedDate not supplied

Chevron osteotomy.

Explore the source record for details and available documents.

Hallux Valgus↗
PubMedDate not supplied

Subluxation of the hip joint during femoral lengthening.

Three cases of subluxation of the hip joint occurred during femoral lengthening using the Wagner technique. This infrequent complication, which may result from a conflict of force vectors at the hip joint during lengthening, can, when left untreated, nullify the benefits of such a procedure. We suggest that increased awareness and closer monitoring can improve the prognosis for patients undergoing this course of therapy, especially where a previous hip operation has been performed.

Bone Lengthening↗