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Biomedical subjects

A Chatterjee

Publications and source records attributed to A Chatterjee.

At least 325 records · Page 18Linked to original sources
PubMed1982

Prevalence and aetiology of cataract in Punjab.

Three districts in the Punjab plains were surveyed in 1976-7 for senile cataract and potential risk factors. The prevalence of senile cataract was 15.3% among 1269 persons examined who were aged 30 ang older, and 4.3% for all ages. These figures confirmed previous reports of high prevalence. The prevalence was 1% for ages 30-49 and increased markedly in the sixth and seventh decades to 67% for ages 70 and older. Univariate age-adjusted analyses of selected socioeconomic, demographic, dietary, and other variables suggested that a higher prevalence was associated with being widowed, low education, use of rock salt in cooking, infrequent consumption of various protein foods (beans and lentils, milk, eggs, and curd), short height, and low weight. Multivariate analysis further suggested low total protein consumption as a risk factor that may account for as much as 40% of the excess prevalence of Punjab cataract over that in a US population study.

Age Factors↗
PubMed1981

Intrauterine contraceptive devices: failure of unilateral intrauterine device in inducing luteolysis in rabbits, rats and mice.

Insertion of a unilateral intrauterine device (IUD) on day 1 pc in rabbits and rats or day 2 pc in mice is found to interrupt pregnancy in the device-bearing uterine horn, but does not affect blastocyst implantation or fetal development of the contralateral side. It is also evident that following surgical ablation of the ovary of the non-IUD side, the ovary of the IUD-bearing side can effectively maintain pregnancy and fetal growth as in controls. The possible mode of action of the IUD has been discussed.

Animals↗
PubMed1980

The possible mode of action of prostaglandins: XVI. A study to assess the local effect of prostaglandins E1, E2 or F2 alpha in the regulation of male fertility.

A single intratesticular injection of prostaglandin E1 (PGE1) or prostaglandin E2 (PGE2) at a dose of 2.5 mg/kg was found to interfere with the fertilizing ability of epididymal spermatozoa of the test animals both in the injected and contralateral control sides. Prostaglandin F2 alpha, conversely, was found to be ineffective in terms of fertility of the test animals in the same experimental model. The beneficial effect of testosterone therapy concurrently with either of the PGE1 or PGE2 in maintaining the fertility of the animals has been recorded and discussed in terms of the mode of action of prostaglandins.

Animals↗
PubMed1979

Radioprotection by DMSO of mammalian cells exposed to X-rays and to heavy charged-particle beams.

Populations of G1-phase Chinese hamster cells in stirred suspensions containing various concentrations of DMSO were irradiated with 250 kV X-rays or various heavy charged-particle beams. Chemical radioprotection of cell inactivation was observed for all LET values studied. When cell survival data were resolved into linear and quadratic components, the extent and concentration dependence of DMSO protection were found to be different for the two mechanisms. The chemical kinetics of radioprotection for single-events were similar for LET values up to those which gave the maximum RBE. DMSO protected to a lesser extent against energetic argon ions at an median LET of approximately 220 keV/micron. These data could indicate the contribution of indirect action by hydroxyl radicals and hydrogen atoms to cell inactivation by single-hit and double-hit mechanisms for various radiation qualities. The decrease in RBE observed at very high LET may result, in part, from reduced yields of water radicals at 10(-9)-10(-8) s resulting from radical recombination mechanisms within the charged particle tracks.

Animals↗
PubMed1979

Indomethacin and uterine evacuation of conceptus in rats: possible mode of action.

Indomethacin at a dose of 2.5 mg/kg from day 18 through day 20 of pregnancy was found to extend the duration of gestation for 2-3 days over the control value. Conversely, prostaglandin F2 alpha (PGF2 alpha) at a dose of 2.0 mg/kg on day 18 of pregnancy induced premature parturition. PGF2 alpha given concurrently with indomethacin resulted in neutralisation of the drug action and the animals delivered viable pups as identically recorded in controls. Failure of indomethacin to extend the length of pseudopregnancy in either bilaterally hysterectomized or bilaterally decidualized pseudopregnant rats revealed that the lengthening of the duration of pregnancy caused by indomethacin is not due to an extension of luteal span, but results from relaxation of the uterine smooth musculature.

Animals↗