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Biomedical subjects

A Chantepie

Publications and source records attributed to A Chantepie.

69 records · Page 4Linked to original sources
PubMed1982

[Poisoning by externally-administered ethanol in an infant].

The occurrence of unexplained coma in a 15 day-old infant led to suspect an intoxication. Major ethanol poisoning (alcohol blood level: 4.4 g/l) was thus discovered in this child treated with alcohol-containing dressings. Symptomatic treatment alone resulted in favourable evolution of coma in a few hours. Half-life of alcohol was shown to be 17 hours in this child. The interest of the case reported is to remind of the dangers of percutaneous absorption of some products, especially in young infants and the importance of toxicological investigations in children with unusual manifestations of unknown etiology.

Alcoholic Intoxication↗
PubMed1981

[Fanconi's disease associated with hepato-splenic peliosis (author's transl)].

The authors report a case of Fanconi's disease equilibrated for a period of 8 years by androgen therapy. The patient died after interruption of treatment; the clinical picture comprised hepatomegaly, jaundice, pancytopenia. The autopsy showed hepato-splenic peliosis and acute tuberculosis. The subject of peliosis is brought up to date by a thorough review of current literature and the relationships between steroid treatment and hepatic complications are discussed.

Adolescent↗
PubMed1980

[Left superior vena cava simulating abnormal pulmonary venous return].

The case of a seven year old boy with coarctation of the aorta and a left superior vena cava (SVC) draining into the left atrium is reported. Usually, in this condition the circulation is centripedal, descending from the left SVC to the left atrium and leading to systemic cyanosis or desaturation. In this case, the circulation was centrifugal and ascending from the left atrium to the left SVC to the innominate vein, leading to a left-to-right shunt as in abnormal pulmonary venous return. The left-to-right shunt flow was 4.2 l/mn and the ratio of pulmonary to systemic flow was 1.8: there was no pulmonary hypertension. This type of circulation is very rare and only two other cases were found in the literature. It may be explained by the proximity of the left pulmonary veins to the left SVC and by a functional mitral obstacle due to the increased pulmonary return. Simultaneous correction of the coarctation and ligature of the left SVC was carried out by left thoracotomy without cardiopulmonary bypass.

Aortic Coarctation↗
PubMed1980

[Mycotic aneurysm of bronchial artery. Apropos of a case in an infant].

The authors report the case of a 15 day old neonate presenting a beta hemolitic streptococic (group A) infection, followed by cardio-respiratory failure and radiological opacification of the left superior lobe associated with ventilatory troubles at the left lung base. Massive hemoptysis made an angiographic study mandatory with the diagnosis of a mediastinal vascular tumor placed besides the left descending aorta with compression of the left bronchovasculary pedicule. Tumor ressection was not possible during surgical exploration and a left superior lobectomy was performed. Histological examination showed pulmonary infarctus. The child died a few weeks later. Autopsy revealed mycotic arterial aneurysm of the superior bronchic artery, a very rare lesion considering its localisation and the age of the patient.

Aneurysm, Infected↗
PubMed1979

[Monitoring of intracranial pressure in 2 severe cases of Reye's syndrome].

The intracranial pressure (PIC) of two children with Reye's sundrome aged 9 years 7 months and 4 years 7 months was monitored for 9 and 5 days respectively with a subdural device. This provided a useful guide to the treatment that was necessary to reduce the very high intracranial pressure. One of the patients died of uncontrollable raised intracranial pressure (HIC). This monitoring technique should be used in all cases of HIC.

Child↗
PubMed1978

[Hemifacial microsomia and cardiac malformations. Apropos of 2 cases].

The authors report two cases of infants with complex heart disease comprising transposition of the great vessels, and a major unilateral facial anomaly involving the ear and the mandible, conforming to the description of hemifacial microsomia. The facial anomalies seen are defined and placed in the classification of known syndromes. The incidence of heart disease associated with facial microsomia is about 20% and in 2/3 of cases it is a ventricular septal defect or a tetralogy of Fallot. An analysis of aetiological factors shows that syndromes of the first two branchial arches are usually sporadic and that they may be the result of intra-uterine disease. The mechanism of the facial lesions is probably vascular.

Abnormalities, Multiple↗
PubMedDate not supplied

Transient hypertrophic cardiomyopathy in neonates after acute fetal distress.

We report three cases of transient myocardial hypertrophy, diagnosed by echocardiography, occurring between the second and seventh days of life in neonates with initially normal ventricular myocardial wall thickness. The three term neonates had perinatal injury with acute fetal distress. In all three cases electrocardiographic and biologic signs of myocardial ischemia were present. The first echocardiographic results showed abnormalities in systolic or diastolic left ventricular function, without hypertrophy of the walls. The hypertrophic cardiomyopathy (HCM) occurred between days 2 and 7 and affected first the interventricular septum and the free wall of the right ventricle. The left ventricular posterior wall subsequently became abnormal, resulting in severe overall myocardial hypertrophy, which finally disappeared in all three cases between 1 and 5 months of life. Such observations of early severe and transient HCM have not been previously reported. We believe it is a consequence of myocardial ischemia due to acute fetal distress. The prognosis of this type of HCM is good, in contrast to that of other primitive HCM occurring in neonates.

Acute Disease↗
PubMedDate not supplied

Effects of indomethacin on cerebral hemodynamics at rest and during endotracheal suctioning in preterm neonates.

The effect of therapeutic doses of indomethacin versus placebo (saline) on cerebral hemodynamics was studied in nine mechanically ventilated preterm infants. Recordings were made at rest and during endotracheal suctioning. Indomethacin at a dose of 0.2 mg/kg body weight was infused over 5 min. Compared to placebo, there was a significant decrease in Doppler mean frequency in the anterior cerebral artery within minutes of starting the indomethacin infusion during the resting period after the first (p less than 0.01), second (p less than 0.001) and third (p less than 0.025) doses. This effect has persisted during endotracheal suctioning. Thus, indomethacin alters cerebral hemodynamics by decreasing Doppler mean frequency. In view of these findings, and particularly because of the alteration in the resting cerebral hemodynamics, the recommendation of prophylactic treatment with indomethacin remains questionable.

Blood Flow Velocity↗
PubMedDate not supplied

[Effects of PGE1 in neonatal aortic coarctation].

In order to estimate the efficacity of prostaglandine E1 (PGE1) to dilate the obstruction in coarctation of the aorta (CoAo), we studied 16 full term neonates with heart failure. Over the 16 neonates, there was 5 with isolated CoAo and 11 with an intracardiac shunt. Over the 11 neonates, 7 had pulmonary hypertension. PGE1, at a dose of 0.05 microgram/kg/min associated to the classical treatment of heart failure were given on the 6 day of life. Effects of PGE1 were evaluated on clinical basis (presence of femoral pulse, blood pressure), echocardiographical basis (ductus arteriosus and aortic isthmus diameter) and morphological basis. In 15 neonates, the ductus arteriosus was open, in all cases CoAo diameter was the same. In 7 neonates with pulmonary hypertension, femoral pulse appeared. In conclusion, PGE1 increases post ductal perfusion by a right to left shunt through the ductus arteriosus, only in cases where pulmonary hypertension is present. No direct action on the aortic isthmus was observed.

Alprostadil↗