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Biomedical subjects

A Chalvardjian

Publications and source records attributed to A Chalvardjian.

34 records · Page 2Linked to original sources
PubMed1971

Agarose--starch gel electrophoresis of rat serum lipoproteins.

Rat serum lipoproteins were separated into at least four fractions by agarose-starch gel electrophoresis. The system used was discontinuous in that glycine and sodium barbitone buffer was used in the reservoirs and Tris buffer was used for the gels. The four major bands could be related to the pattern obtained by ultracentrifugation. The high density lipoproteins consisted of at least two poorly resolved bands and were not separated from albumin. The vertical gel apparatus was further modified to accept 0.4 ml of rat plasma, which was prestained with Sudan black. After electrophoresis the different lipoprotein bands could conveniently be cut out and the lipid phosphorus determined. The addition of Sudan black B decreased the recovery of the low and high density lipoproteins by 5-9%. However, the recovery of phospholipids was reproducible (80 +/- 2%) and the high density lipoproteins contained over two-thirds of the plasma lipid phosphorus.

Animals↗
PubMedDate not supplied

Cytologic diagnosis of extravesical malacoplakia.

Malacoplakia, a rare form of chronic granulomatous inflammation, most frequently involves the urinary tract of middle-aged women. The disease represents an unusual inflammatory response to bacteria, most commonly Escherichia coli, and probably reflects some dysfunction in the immune system of the host. We describe two cases of malacoplakia involving in one patient the vagina and in the other the perianal subcutaneous tissue and lung. In both cases, the diagnosis was made concurrently by cytology and histologic examination of tissue sections. This, in turn, led to the institution of appropriate therapy with complete resolution of the disease. In smears, the characteristic von Hansemann histiocytes are larger than alveolar macrophages. They have a reticulated granular cytoplasm that is caused by excessive accumulation of lysosomal bodies, some of which upon mineralization give rise to the pathognomonic Michaelis-Gutmann body. The latter, which is usually intracellular, can be distinguished readily from psammoma bodies and should not be confused with yeasts.

Abscess↗
PubMedDate not supplied

Adrenal pheochromocytoma mimicking small cell carcinoma on fine needle aspiration biopsy. A case report.

BACKGROUND: Fine needle aspiration biopsy (FNAB) is a sensitive and specific technique in the diagnosis of adrenal tumors. However, in rare cases the cytomorphologic features may mimic small cell neoplasms. CASE: A 54-year-old male presented with a history of hypertension and left flank pain of recent onset. Abdominal computed tomography (CT) showed a 4-cm mass involving the left adrenal gland. Fine needle aspiration biopsy (FNAB) showed groups of small round cells with hyperchromatic nuclei. The findings were highly suspicious for metastatic small cell carcinoma. Subsequently it was learned that the mass had been noted three years earlier on CT studies but had grown from 2.5 to 4 cm. A chest radiograph was unremarkable. The clinical findings were more in keeping with a primary adrenal tumor. Immunohistochemical staining done retrospectively on the cell block showed positive reactivity for chromogranin and neuron-specific enolase. These findings, correlated with the clinical features, were in keeping with a diagnosis of pheochromocytoma. Left adrenalectomy revealed a pheochromocytoma. CONCLUSION: Adrenal pheochromocytoma should be included in the differential diagnosis of small round cell neoplasms seen on FNAB of the adrenal gland. Immunohistochemistry and clinical findings are helpful in reaching the correct diagnosis.

Adrenal Gland Neoplasms↗