Biomedical subjects

A Chalmers

Publications and source records attributed to A Chalmers.

65 records · Page 4Linked to original sources

PubMed1978

Postdiarrheal arthropathy of Yersinia pseudotuberculosis.

Two patients with acute gastroenteritis in whom polyarthritis subsequently developed were found to have positive serologic results for Yersinia pseudotuberculosis. With resolution of the arthropathy the antibody titres decreased. While the patient without the histocompatibility antigen HLA-B27 had an acute, self-limited arthritis, the patient with this antigen had a more chronic arthritis. Serologic typing and stool culture for Y. pseudotuberculosis should be done in cases of postdysenteric arthritis.

Acute Disease↗

PubMed1978

Nail lesions in systemic lupus erythematosus.

Unusual nail changes have been observed in 42 of 165 patients with systemic lupus erythematosus (SLE) followed at the Wellesley Hospital, Toronto, Canada, over the past seven years. These changes had almost the same frequency as mucous membrane ulcerations seen in 31% of the patients. Nail changes were associated with active disease in 39 of the 42 patients. Patients with nail changes had a significantly higher incidence of Raynaud's phenomenon and mucous membrane ulcerations than patients without these changes. There was no increased incidence of other skin manifestations or of systemic vasculitis in these patients. Thus, nail changes may be an additional helpful criterion in the diagnosis of SLE.

Female↗

PubMed1978

Systemic lupus erythematosus with negative LE cells and antinuclear factor.

In the course of a prospective study of 165 patients with SLE a subgroup of eight patients with active SLE yet with persistently negative tests for ANF and LE cells was identified. These patients were characterized by a photosensitive skin rash with a negative lupus band test, a high incidence of arthritis, mild form of renal disease, and a positive family history for connective tissue disease. Antibodies to DNA and cytoplasmic antigens were detected in a few.

Adult↗

PubMed1976

Oxalate excretion during carbohydrate infusions.

Oxalate metabolism was assessed in normal rats and rats deficient in vitamins B-1 and B-6 during intravenous infusions of solutions containing glucose, fructose, sorbitol or xylitol. Urinary excretions of oxalate, glyoxylate and glycine were considerably increased in vitamin B-6 deficient rats infused with xylitol. Significant amounts of 14C-oxalate were excreted only in vitamin B-6 deficient rats infused with U 14C-xylitol. Correction of vitamin B-6 deficiency resulted in a return to normal of urinary oxalate excretion and percentage of U 14C-xylitol excreted as 14C-oxalate. The results suggest that xylitol metabolism produces an increased activity in pathways leading to oxalate formation in vitamin B-6 deficient rats.

Animals↗

PubMed1975

HL-A27 and ankylosing spondylitis in B.C. Indians.

HL-A antigens were determined in Haida and Bella Coola native Indians, two communities known to have a high prevalence of ankylosing spondylitis. Tests were conducted on those with x-ray evidence of sacro-iliitis and on a sample of the community at large. Sacro-iliitis was found to prevail in approximately 10 per cent of adult Haida males and in over two per cent of Bella Coola adult males. Of 20 Haidas with sacro-iliitis, 17 were HL-A 27 positive. Fifty per cent of the Haida community at large were HL-A 27 positive. Three Bella Coolas known to have sacro-iliitis were all HL-A 27 positive, while 25 per cent of the community sampled at large were HL-A 27 positive. About one in five adult Haida males who were HL-A 27 positive showed evidence of sacro-iliitis, a proportion close to that ascertained in Caucasian communities. It would appear, therefore that the risk of disease in HL-A 27 positive Bella Coola males is considerably lower.

Adult↗

PubMed1972