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Biomedical subjects

A Celada

Publications and source records attributed to A Celada.

At least 109 records · Page 6Linked to original sources
PubMed1980

Increased frequency of HLA-DRw3 in systemic lupus erythematosus.

The distribution of HLA antigens was studied in 40 patients suffering from systemic lupus erythematosus. For loci A and B, increased frequencies of A1, B8 and the presence of only one B antigen were found. Nevertheless, in relation to the number of antigens tested, this increase was not significant. For the DRw locus, DRw3 was significantly increased (P < 0.001, after correction for the 39 antigens tested). However, the patients with DRw3 did not show any correlation with a specific clinical picture or the presence in their serum of lymphocytotoxic antibodies or autoantibodies against T and B lymphocytes.

Adult↗
PubMed1980

Effect of thiamphenicol on iron absorption.

The effect of thiamphenicol (a protein synthesis inhibitor) administration on iron absorption was studied in rabbits. Iron absorption was measured in a whole-body counter using 59Fe, and plasma iron turnover (PIT) was simultaneously determined with 55Fe. In comparison with the controls, the group receiving thiamphenicol showed no significant difference in PIT (p > 0.05), while iron absorption was increased (p < 0.0001).

Animals↗
PubMed1980

Quantitation of immunoglobulin-associated HBs antigen in patients with acute and chronic hepatitis, in healthy carriers and in polyarteritis nodosa.

The incidence and amount of immunoglobulin (Ig)-bound hepatitis B associated surface antigen (HBs) has been determined in various forms of hepatitis B, using radioimmunological techniques. Both the total concentration of HBs and that of Ig-bound HBs were measured in serum samples from 54 patients with acute hepatitis B, 28 with chronic hepatitis and 28 healthy chronic carriers. The following observations were made: (1) Ig-bound HBs was detected in 79% of patients with acute hepatitis B in one or several samples; the highest level of Ig-bound HBs was observed 60-120 days after the onset of jaundice, while the total amount of HBs was progressively decreasing. (2) Ig-bound HBs was detected in 46% of 28 patients with chronic hepatitis. This frequency was higher in patients with chronic aggressive hepatitis (75%) than in patients with chronic persistent hepatitis (33%). The mean levels of total HBs and Ig-bound HBs are more significantly increased in patients with chronic aggressive hepatitis than in patients with chronic persistent hepatitis or healthy carriers. (3) Ig-bound HBs was detected in 46% of healthy chronic carriers. (4) The persistence of Ig-bound HBs in serum was not related to the antigen sub-type. (5) Extra-hepatic manifestations suggestive of an immune complex disease were observed in only 2 of 31 patients with chronic persistence of Ig-bound HBs. These data suggest that small amounts of HBs-antibody complexes may persist in circulating blood without always being harmful for the host.

Acute Disease↗
PubMed1980

Hypergammaglobulinemic purpura and Sjögren's syndrome in a child.

Hypergammaglobulinemic purpura of Waldenström and Sjögren's syndrome are rarely reported in children. This paper reports the case of a 12-year-old girl suffering from both diseases. In the serum of this patient the presence of circulating immune complexs was demonstrated, but there was no clinical sign suggesting an immune complexe disease. After a 28-month follow-up no clinical or biological change was observed.

Antigen-Antibody Complex↗
PubMed1980

Effect of autologous and homologous serum and circulating immune complexes on monocyte functions of patients with solid tumours.

Some functions of monocytes (phagocytosis, bactericidal capacity, handling of endocytosed 51Cr-SRBC and chemotaxis) were studied in fifty patients with solid tumours and in fifty controls. In the presence of autologous serum, the catabolism of endocytosed 51Cr-SRBC and the phagocytic capacity were similar in tumour and control monocytes, while the bactericidal capacity of tumour monocytes was increased. In the presence of pooled AB sera the catabolism and the bactericidal capacity were decreased in tumour monocytes as compared with autologous serum. Tumour sera did not enhance the functions of normal monocytes. Inactivation of pooled tumour or AB sera resulted in decrease of bactericidal capacity in tumour and control monocytes. Using the Clq-binding test, we detected circulating immune complexes in 36% of sera. The presence or absence and the quantity of such complexes did not correlate with the different functions studied in either tumour or normal monocytes. Finally, the chemotactic activity of monocytes was studied using the migration under agarose technique. No difference was found between tumour and control monocytes. On the other hand, the presence of a chemotactic inhibitor was not revealed in tumour sera. These observations suggest that monocytes from tumour patients require factor(s) present in autologous serum as well as autologous cellular component(s) to achieve normal functions.

Aged↗
PubMed1979

[Sjögren's syndrome, mixed cryoglobulinemia and Waldenström's purpura (author's transl)].

A 66-year-old patient was hospitalized after the appearance of a deep ulcer in the posterior face of the right calf. She had purpuric spots on the lower limbs only, as well as parotiditis, especially on the left side, and was affected with dryness of the mouth but not of the eyes. The patient also presented, in contact with the cold, Raynaud's phenomenon. Physical examination revealed as pathologic signs: purpura of the lower limbs, a deep ulceration on the right calf, parotiditis, and a reduction in the pallaesthesia of the lower limbs. Biologically an increased sedimentation rate, elevation of the total proteins (particularly the gammaglobulins), positive antinuclear factor, reduction of the total complement and of the C3 fraction, circulating immunocomplexes, positive latex test, positive Sia test, and the presence of mixed cryoglobulin IgG-IgM type kappa, stood out. The patient was diagnosed as having Sjögren's syndrome, mixed cryoglobulinemia and Waldenström's purpura. Probably the two latter conditions characterized by the presence or circulating immunocomplexes are part of the same process. According to recently studies described in the literature the relationships between these three entities are discussed, as well as the possibility of developing lymphoproliferative syndromes under certain immune stimuli.

Blood Protein Disorders↗
PubMed1979

The clinical measurement of urinary total hydroxyproline excretion.

The effect of dietary control on the day-to-day variation in total hydroxyproline excretion has been examined in two studies. In the first, a normal volunteer ate a controlled diet containing varying gelatin supplements for several weeks. In the second, the effect of removing hydroxyproline-containing foods from the diets of 8 volunteers was examined. Both studies confirm that the day-to-day variation in total hydroxyproline excretion falls when the gelatin content of the diet is decreased, whether the results are expressed as total hydroxyproline excretion rate or as the total hydroxyproline: creatinine ratio. This fall in variation takes place within 24 h of dietary control beginning and therefore longer periods of dietary restrictions to achieve optimum precision in the measurement of total hydroxyproline are unnecessary. For some analytical methods, results are better expressed as the ratio total hydroxyproline:creatinine than as the total hydroxyproline excretion rate.

Adult↗
PubMed1979

Reduced leucocyte alkaline phosphatase activity and decreased NBT reduction test in induced iron deficiency anaemia in rabbits.

Iron deficiency anaemia was induced in rabbits by repeated bleeding. The leucocyte alkaline phosphatase (LAP) of 26 +/- 28 units was significantly reduced compared with control values of 233 +/- 35 units (P less than 0.001). Leucocyte NBT reduction was also diminished, both in Hanks solution (P less than 0.01) and in autologous serum (P less than 0.001). After administration of iron, these values returned to normal. The results suggest that reduced LAP may reflect a deficiency of iron dependent constituents which are necessary for the integrity of normal granulocyte metabolism.

Alkaline Phosphatase↗
PubMed1978

[Effect of chronic alcohol administration and of folic acid deficiency on iron absorption].

The influence of chronic alcohol ingestion and artificially induced folic acid deficiency on iron absorption has been measured in rabbits by whole body counter. Results show that chronic alcohol ingestion does not modify iron absorption. Folic acid deficiency increases iron absorption by two probable mechanisms: first by increased plasma iron turnover (PIT), which parallels ineffective erythropoiesis, and second by a probable direct effect on the intestinal mucous membranes. This second mechanism appears to be independent of PIT: concomitant deficiency of folic acid and alcohol ingestion produces an increase in iron absorption without modification of PIT. Experience with drugs inhibiting protein synthesis suggests that this increase may be mediated by decreased protein synthesis.

Alcoholism↗