Plasma lead values: are they accurate?
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Biomedical subjects
Publications and source records attributed to A Cavalleri.
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The results obtained with intermittent bromocryptine treatment from the fifth day after the beginning of menstruation until the second day after the basal temperature rise, in 14 women with hyperprolactinemic amenorrhea-galactorrhea and in whom menses had previously been induced by continuous treatment, are presented. All women had menses without reappearance of galactorrhea; serum FSH, LH, estradiol, and progesterone followed a normal physiologic trend. Only prolactin rose again in the second phase of the cycle, in which lower levels of progesterone were also found, but without any significant interference in the clinical and hormonal trend. It is stressed that administration of bromocryptine during the first part of the cycle might substitute for continuous administration, thereby reducing drug consumption and hence possible side-effects as well as the cost of treatment.
Lead levels were measured in red blood cells and plasma of 75 pregnant women and their infants at delivery. No significant differences were found by comparing maternal and fetal values and a statistically significant positive correlation was evidenced, higher for plasma levels. The results suggest that the diffusible form of maternal lead in plasma influences the lead transferred to the fetus more directly. The highly significant correlation found between the maternal and fetal ratio of lead in plasma to lead in erythrocytes seems to be in favor of inborn factors influencing the equilibrium between the two compartments in which lead is distributed.
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Serum thyroxine and blood lipids were assayed in 45 subjects exposed to carbon disulfide (CS2). A highly significant statistical reduction of thyroxine in relation to the exposure time was found and the levels appeared lower in the subjects with retinal vessel alterations. A significant interrelation between cholesterol and serum thyroxine was also evidenced. Serum thyroxine assay is suggested as a reliable test in the early diagnosis of CS2 poisoning.
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