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Biomedical subjects

A Cavallari

Publications and source records attributed to A Cavallari.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Control of the patency of porto-systemic anastomoses].

After having discussed the direct and indirect methods to control the patency of porto-systemic anastomoses, the Authors report on their series of 42 cases (28 side-to-side porto-cava shunts, 6 end-to-side porto-cava shunts, 6 spleno-renal shunts, 2 mesenterico-cava shunts) where the postop. control was carried out with portography, hepatic superselective arteriography in 29 cases, transcaval catheterism of the anastomosis in 6 patients, and pre-op., and post-op. echotomography in 15 cases. Portography revealed 39 cases of patent anastomosis and thrombotic occlusion in 3 cases. The typical sign of shunt patency is the visualisation of the inferior V.C. and the less frequent disappearance of right gastric reflux. Furthermore the investigations consented the evaluation of altered post-shunt hepato-portal flow: side-to-side porto-cava shunt (25 patent anastomoses) revealed a complete deviation of portal glow towards the I.V.C. and in 15 cases there was inverted portal flow; portography after splenorenal shunt (5 cases of patent anastomosis) showed a preserved hepatopetal portal flow only in early controls (7 days) while in all long term controls it was hepatofugal. In 13 cases the morphology of the hepatic arterial system was compared before and after surgery; in 12 cases the hepatic artery was larger and its intrahepatic branches more tortuous after surgery Ultrasonography revealed only 8 patent shunts out of 15 examined since the amount of gas in the bowel rendered the exam technically insufficient.

Adult↗
PubMed1981

Plasma amino acid patterns in experimental acute hepatic failure: comparison between hepatectomy and liver devascularization in pigs.

To clarify the physiopathologic mechanism leading to a marked increase in aromatic amino acids (AAA) in acute hepatic failure (AHF), we compared two experimental models of AHF. Ten pigs were submitted to one-stage hepatic devascularization (group A); in eight other pigs total hepatectomy was performed (group B). The animals were maintained under constant glucose infusion. The mean survival time in group A was 23 +/- 2 hours; after hepatectomy it was 30 +/- 4 hours. Hepatic coma progressively deepened from 8 +/- 3 hours in Group A animals and was delayed until 17 +/- 5 hours in the anhepatic pigs. AAA, methionine, and tryptophan immediately increased markedly in pigs with liver ischemia. In group B animals, AAA showed a slight increase only 18 hours after hepatectomy, whereas there were no significant differences in methionine and tryptophan. The different amino acid patterns in the two groups of animals demonstrate that hepatocyte necrosis is a major source of plasma amino acids after liver devascularization. The slight increase in AAA after total hepatectomy suggests that a release mechanism from muscular mass is involved in the later stages of the experiment. The onset of coma is related to the increase in AAA rather than to alterations in blood ammonia that did not differ in either group of animals.

Amino Acids↗
PubMed1980

[Hepato-portal circulatory changes after splenorenal anastomosis].

Hepatoportal circulation changes after the shunt were examined angiographically in 5 patients subjected to splenoportal anastomosis and splenectomy. Arterioportography was employed in all cases. Catheterisation of the anastomosis was carried out in 1 patient and suprahepatic phlebography in another. The anastomosis was found to be patent in all cases. A hepatopetal portal flow was noted solely in the two patients examined six days after surgery. Disappearance of hepatic portal perfusion was observed in one of these patients on the 15th postoperative day. Controls carried out one month, one year, and five years after the operation showed that the mesenteric-portal flow was fully deviated through the shunt towards the vena cava in all patients. Selective hepatic arteriography showed an inverted portal flow in 3 patients. An increase in the calibre of the trunk of the hepatic artery and the entire intrahepatic artery network was always present.

Adult↗
PubMed1980

[Hepatoportal circulatory modifications after splenorenal anastomosis (author's transl)].

An angiographic study was performed in five patients following splenorenal anastomosis with splenectomy, to evaluate hepatoportal circulatory modifications after surgery. All cases had angiographic investigations by arterioportography. In one case catheterization of the anastomosis was also associated and in another case hepatic phlebography. Hepatopetal blood flow was observed in only two patients examined within 6 days of the operation. In one of these cases a second angiographic examination was made 10 days later and demonstrated that hepatopetal portal flow had disappeared. In the other patients, examined after one month, one year, and five years respectively, the mesenteric blood flow was completely deviated through the anastomosis towards the inferior vena cava, without any opacification in the portal vein. In three patients, selective hepatic arteriography showed inversed portal flow. All late investigations demonstrated a great increase of hepatic artery size and of the intrahepatic arterial branches.

Celiac Artery↗
PubMed1979

Cyclophosphamide and iphosphamide against Lewis lung carcinoma: evaluation of toxic and therapeutic effects.

In the present report, investigations have been carried out to evaluate toxic and therapeutic effects of cyclophosphamide vs its isomer iphosphamide. Cytostatic action of the 2 drugs was assayed on the murine Lewis lung carcinoma (3LL). It has been observed that iphosphamide is less toxic as compared to cyclophosphamide (LD50 IP LD50 CP = 1.5); on the other hand, to reach the same therapeutic effectiveness on 3LL, an iphosphamide dose 1.6 - 2 times higher than that of its parent compound is necessary.

Animals↗