Search PubMed⌕ Search

Biomedical subjects

A Catterall

Publications and source records attributed to A Catterall.

At least 37 records · Page 2Linked to original sources
PubMed1987

The Chiari pelvic osteotomy. A review of the long-term results.

We report the clinical and radiographic results of the Chiari pelvic osteotomy in 49 hips (45 patients) at an average of 14 years after operation. Of these hips, over half had minimal or no pain, had good or excellent results as assessed by the Harris hip score, and could walk at least three miles; three-quarters, however, had a positive Trendelenburg sign. A younger age at operation and a painless hip with no radiographic evidence of degeneration before operation were associated with a higher hip score at review. The percentage of hips without degenerative changes fell from 68% before operation to 15% at final review. There were no major complications and it was found that a Chiari osteotomy need not interfere with normal childbirth.

Acetabulum↗
PubMed1986

Abnormalities in fracture healing induced by vitamin B6-deficiency in rats.

Vitamin K1 is the intermediate carrier of reducing equivalents in mineralization. In fracture-healing in the rat metatarsal the primary source of these reducing equivalents appears to be NADPH, generated from glucose 6-phosphate dehydrogenase (G6PD) activity. Because recent evidence indicated that stimulation of G6PD activity can be induced by putrescine, derived from pyridoxal phosphate-dependent ornithine decarboxylase activity, the effect of pyridoxine (vitamin B6) deficiency has been studied in this system. Vitamin B6-deficiency caused marked diminution in the G6PD activity in the periosteal region of bone-formation and in the developing callus, with significant delay in the maturation of the callus and union. It also caused changes in the bone suggestive of imbalance in the coupling between osteoblasts and osteoclasts. These results suggest that the vitamin B6-status may be important in fracture-healing.

Animals↗
PubMed1986

Ultrasound of the hip: a review of the applications of a new technique.

In an attempt both to reduce gonadal irradiation incurred with conventional radiology, and to image the unossified structures of the neonatal hip, several groups have undertaken studies on aspects of hip ultrasound particularly with reference to the paediatric patient. The ultrasound anatomy of the unossified infant hip has been described by Graf in Austria. The same author has devised an ultrasonographic classification for hip dysplasias and dislocations which has gained widespread acceptance in mainland Europe. Two studies have appeared exploring the use of ultrasound for the measurement of femoral neck anteversion but as yet these have not been compared with CT or trigonometric methods of assessment. Ultrasound has been shown to be effective in the detection of hip joint effusions, but its role in the management of the "irritable hip" has yet to be defined.

Hip↗
PubMed1986

Hinge abduction of the hip. Diagnosis and treatment.

Hinge abduction is an abnormal movement of the hip which occurs when a femoral head, deformed as a result of avascular necrosis or Perthes' disease, fails to slide within the acetabulum. Patients with this condition present with pain and shortening and in some cases arthrodesis has been recommended. We report 27 cases in which the diagnosis had been established by arthrography. The satisfactory results of abduction-extension osteotomy of the femur in 26 hips with this condition are reported.

Adolescent↗
PubMed1986

The torn acetabular labrum.

Eleven patients with tears of the acetabular labrum are discussed and the syndrome of the torn labrum is defined. In all cases the lesion was associated with acetabular dysplasia, and a constant early radiological sign was a cyst in the lateral aspect of the acetabulum. The diagnosis was confirmed by arthrography. It is suggested that these tears are degenerative, occurring as a consequence of abnormal stresses imposed by the uncovered lateral portion of the femoral head. Once a tear is present a localised stress point occurs on the femoral head, leading rapidly to degenerative arthritis.

Acetabulum↗
PubMed1986

Adolescent hip pain after Perthes' disease.

Whereas the majority of patients with Perthes' disease have relatively benign diseases with good long-term outcome, approximately 9.5% develop deteriorating symptoms that require surgery before the age of 35 years. The growth disturbance that produces the deformity of the femoral head induces a fixed subluxation, resulting in hinge abduction. This condition almost certainly leads to the early onset of degenerative changes. Abduction extension osteotomy relieves pain, improving leg length discrepancies and range of movement. The surgeon hopes that the operation will sustain long-term hip function.

Adolescent↗
PubMed1985

Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis.

If gamma-carboxylation, by the vitamin K1 - cycle, of glutamate residues of bone-matrix peptides is essential for the formation of bone, the circulating levels of this vitamin might indicate the potential efficiency of this process. Methods involving HPLC with electrochemical detection have very recently been developed for assaying the low levels of vitamin K1 that occur in normal plasma. Using such methods, we found that the circulating levels of vitamin K1 in osteoporotic patients (who had sustained either spinal crush-fractures or fractures of the neck of the femur) were significantly lower than those of age-matched control subjects.

Aged↗
PubMed1985

Pathology and classification.

The most important change seen during the early and active phases of this disease is an overgrowth of the articular cartilage with a variable degree of infarction within the bony epiphysis. This accounts for the variable nature of the disease that is observed clinically. Treatment cannot alter the degree of bony infarction present; it can only attempt to control the growth disturbance that is present by maintaining the mobility of the femoral head and hence preventing the adduction contracture, which is the essential prerequisite of serious femoral head deformity.

Cartilage, Articular↗
PubMed1984

Effects on fracture healing of an antagonist of the vitamin K cycle.

The anticoagulant, dicumarol, inhibits the vitamin K cycle by blocking the conversion of the vitamin K epoxide. The effects of dicumarol on ossification have been tested by feeding it to rats in which a closed fracture of the metatarsals had been induced; the effects were studied up to 12 days postfracture. At 12 days, treatment with dicumarol caused a highly significant decrease in the amount of bone produced, without affecting the total size of the callus. Quantitative cytochemistry of unfixed, undemineralized sections showed that dicumarol also markedly affected the periosteal activities of glucose 6-phosphate dehydrogenase and of alkaline phosphatase in the first 2 mm from the fracture measured at 3 and 5 days postfracture when normally, new bone is first formed. In contrast, dicumarol had little effect on these activities in the fully formed callus.

Alkaline Phosphatase↗
PubMed1984

Club foot. Observations on the surgical anatomy of dorsiflexion.

Dorsiflexion has been studied in three normal feet and in three feet with talipes equinovarus to determine the anatomical features which might contribute to the failure of operative treatment to correct the deformity. In the normal feet the movement of dorsiflexion was found to be essentially rotatory in nature and not simply hinging; as dorsiflexion proceeds the fibula moves forwards relative to the os calcis and the calcaneal tendon. In the club feet a posterolateral tether was found; this prevented fibular movement and blocked dorsiflexion. As a result of this study a posterior and lateral release is advocated for the operative correction of the hindfoot in a child with a club foot deformity, particularly under the age of a year.

Clubfoot↗
PubMed1984

Effects of vascular occlusion on the femoral head in growing rabbits.

Temporary vascular occlusion of the femoral head in 6-week-old rabbits was produced by a closed means in a hip spica; the hips were maintained for 24 h in the position of flexion, abduction and internal rotation. All animals developed necrosis of the capital femoral epiphysis, best seen histologically at 2 weeks, and this subsequently recovered. Despite marked histological changes only one hip developed radiographic changes.

Animals↗
PubMed1983

Aerobic glycolysis of bone and cartilage: the possible involvement of fatty acid oxidation.

The apparent paradox of aerobic glycolysis has been investigated in bone and in cartilage. A new cytochemical procedure for hydroxyacyl dehydrogenase (HOAD) activity showed that the maximal activity of this enzyme in both tissues was equivalent to the maximal activity of glyceraldehyde 3-phosphate dehydrogenase (GAPD). The sum of these activities gave a measure of the maximum amount of acetyl-coenzyme A that could be produced. In these tissues, but not in liver which does not exhibit aerobic glycolysis, this summed value exceeded the maximal activity of succinate dehydrogenase (SDH). Consequently, it suggested that where fatty acid oxidation is sufficient to supply all the acetyl-coenzyme A required for the Krebs' cycle, that derived from fatty acid oxidation may inhibit pyruvate dehydrogenase causing accumulation of pyruvate which must be converted to lactate if pentose-shunt activity is to be maintained.

3-Hydroxyacyl CoA Dehydrogenases↗
PubMed1983

Metabolic changes in the cells of the callus during fracture healing in the rat.

Unfixed, undecalcified sections from closed fractures of rat metatarsals have been studied by quantitative cytochemistry from the first week after fracture to late in the fracture-healing process. Alkaline phosphatase activity appeared to be related to calcification. Glucose 6-phosphate dehydrogenase activity was associated with proliferation and with calcification. Studies made with the critical electrolyte Alcian blue technique suggested that whether the ossification process is of the endochondral or membranous type might be predetermined in the relatively undifferentiated callus.

Alkaline Phosphatase↗
PubMed1982

A review of the morphology of Perthes' disease.

There are differences of opinion about the pathogenesis of Perthes' disease. All are agreed that it is due to ischaemia, but the cause of this and the size and number of infarctions are in dispute. Through the generosity of the contributors six whole femoral heads and core biopsies of five other cases have been studied radiographically and histologically. The findings ranged from an ischaemic arrest of ossification in the capital articular cartilage without infarction to multiple complete infarctions of the epiphysial bone. The ensuing reparative process contributes to the pathology, which is of a range to warrant grading or grouping.

Cartilage, Articular↗