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Biomedical subjects

A Cats

Publications and source records attributed to A Cats.

At least 145 records · Page 8Linked to original sources
PubMed1984

Psoriasis and arthritis. II. A cross-sectional comparative study of patients with "psoriatic arthritis" and seronegative and seropositive polyarthritis: clinical aspects.

Arthritis of the terminal joints of the hands and feet occurred more frequently (P less than 0.015) in patients with seronegative poly-arthritis combined with psoriasis (S- P+; n = 92) than in patients with seronegative polyarthritis alone (S- P-; n = 72). However, the prevalence of affection of these joints was too low to consider this feature a sensitive marker for psoriatic arthritis. Furthermore, neither asymmetrical joint involvement nor the absence of ulnar deviation of the fingers appeared to be characteristic of this disease. A positive correlation was found between the presence of nail psoriasis and limitation of function of the distal interphalangeal (DIP) joints. The DIP finger joints and the interphalangeal joints of the toes were affected more often in the S- P+ group than in patients with seropositive polyarthritis without psoriasis (S+ P-; n = 46), but arthritis of the other joints was observed more frequently in the latter group.

Adult↗
PubMed1984

Psoriasis and arthritis. III. A cross-sectional comparative study of patients with "psoriatic arthritis" and seronegative and seropositive polyarthritis: radiological and HLA aspects.

In a group of patients with seronegative polyarthritis and psoriasis, the radiological features and the incidence of histocompatibility antigens were compared with those of a group of patients with seronegative polyarthritis but not psoriasis. No radiological criteria proved to be characteristic of psoriatic arthritis. In the group of patients with seronegative polyarthritis and psoriasis, erosions of the distal interphalangeal (DIP) joints were seen more frequently and were more severe than in the group of patients with seronegative arthritis without psoriasis. For the group of patients with seronegative polyarthritis and psoriasis, correlation was found between psoriatic nail lesions and erosions of the DIP joints, but this correlation was not found between the nail involvement and erosion of the adjacent DIP joint. No significant differences were found for the incidence of histocompatibility antigens between patients with seronegative polyarthritis with or without psoriasis. However, differences were found between these two groups and either the seropositive polyarthritis group or blood bank donors.

Adult↗
PubMed1984

Lymphocyte subpopulations in rheumatoid arthritis. An immunological, enzyme histochemical and morphological study.

Peripheral blood lymphocytes (PBL) and synovial fluid lymphocytes ( SFL ) of patients with rheumatoid arthritis (RA) were examined with monoclonal antibodies, with coated ox red blood cells for the expression of Fc receptors for IgG or IgM (T mu and T gamma cells), and incubated for the demonstration of alpha- naphtyl acetate esterase and acid phosphatase. Equal percentages of OKT4 and OKT8 PBL were found in clinically active and inactive RA patients, and in healthy controls, but decreased percentages of OKT4 and increased percentages of OKT8-positive lymphocytes were found among the SFL . The percentages of T mu and T gamma cells, the presence of HLA-DR membrane antigens on T lymphocytes as well as the staining pattern for the enzymes revealed that SFL of patients with RA were highly activated, compared to PBL of RA patients and healthy controls. It can be concluded from this study that a single determination of OKT4 and OKT8-positive lymphocytes in the peripheral blood of RA patients has no predictive value for disease activity. However, the results of the experiments on T lymphocyte-activation clearly showed preferential activation of SFL compared to PBL, indicating that activation of lymphocytes occurs at the site of inflammation.

Antibodies, Monoclonal↗
PubMed1984

Measurement of disability in Dutch rheumatoid arthritis patients.

A self-administered health-assessment questionnaire (HAQ) was completed by 38 Dutch rheumatoid arthritis (RA) patients and the results compared to those obtained objectively when the same subjects were interviewed and asked to perform standardised tasks included in the HAQ. The results of the interview and the questionnaire showed a high degree of overall correlation and inter-component correlation. The correlation was comparable in outpatients with milder disease and in patients with more severe disease and was not influenced by age. The questionnaire offers a valid approach to the assessment of the functional disability of RA patients.

Adult↗
PubMed1984

Diffuse (eosinophilic) fasciitis. A series of six cases.

Six patients with diffuse fasciitis are described. Their ages range from 12 to 45 years. Five had a typical clinical illness which responded well to corticosteroid therapy but one patient relapsed a year after discontinuation of corticosteroids. One patient had severe skin ulceration resistant to corticosteroids, cytotoxics and plasma exchange and was further complicated by the development of life threatening local and generalised sepsis. Eosinophilia of the blood was not present in any of the cases and not unduly prominent in biopsies of the affected tissue, but characteristic fascial thickening and infiltration by chronic inflammatory cells was diagnostic when a full-thickness biopsy was examined. The natural history and optimal treatment of this condition remain unclear.

Adolescent↗
PubMed1984

Systemic lupus erythematosus and invasive thymoma: report of two cases.

Two cases of invasive thymoma in patients with systemic lupus erythematosus (SLE) are described. In both instances the suspected diagnosis of a mediastinal tumour proved difficult to confirm. Neither surgical removal of the thymoma in one case nor irradiation in the other had any apparent clinical or serological effect on the course of the SLE. Both patients subsequently suffered from respiratory problems and the distinction between recurrent tumour and pulmonary involvement by SLE proved difficult. One patient had a good response, however, to pulse methylprednisolone, but the other later developed recurrence of tumour and died of Pneumocystis carinii infection following cytotoxic therapy three years after discovery of the tumour.

Female↗
PubMed1984

Fc receptors on granulocytes from patients with rheumatoid arthritis and Felty's syndrome.

Receptors for the Fc part of IgG on polymorphonuclear cells (FcR) of patients with rheumatoid arthritis (RA), Felty's syndrome (FS) and healthy controls (HC) were studied by means of a rosetting technique with rabbit IgG coated ox erythrocytes. When cold isolated polymorphonuclear cells (PMN) were incubated at room temperature the percentage of rosette forming PMN (RF-PMN) from HC was more than twice that measured directly after isolation at 4 degrees C. The same phenomenon was observed for PMN from patients with RA although the RF-PMN increased by only 1/3. In contrast warming of PMN from patients with FS did not influence the RF-PMN. The presence of surface bound immunoglobulins and intracytoplasmic immunoglobulins was measured by immunofluorescence and appeared to be inversely related to the RF-PMN. A good correlation between the results of the C1q binding assay (C1qBA) and the immunofluorescence score was observed but no correlation existed between the C1qBA and the RF-PMN. These results indicate that the number of PMN expressing FcR in patients with RA and FS is decreased presumably because of the phagocytosis of immune complex like material. The decrease in the availability of FcR may influence the functions of the PMN.

Antigen-Antibody Complex↗
PubMed1984

C3 receptors on granulocytes from patients with rheumatoid arthritis and Felty's syndrome.

The expression of receptors for the third component of complement (C3R) on polymorphonuclear cells (PMN) from patients with rheumatoid arthritis (RA) or Felty's syndrome (FS) and healthy controls (HC) was studied by means of a rosetting technique using ox erythrocytes coated with rabbit IgM and mouse complement. The percentage of rosette forming PMN (RF-PMN) was found to be increased in patients with FS (59%) and patients with RA (47%) compared to HC (18%), when measured directly after cold isolation of PMN. Incubation at 37 degrees C of cold isolated cells increased the percentage of RF-PMN in all three groups, although the values were significantly higher during the first 45 min of incubation in both patient groups. When incubated with serum from patients with FS at 37 degrees C, cold isolated donor PMN formed significantly more rosettes than after incubation with donor serum. This increase was shown to be due to the presence of circulating immune complexes in the patient sera and could be mimicked by incubating donor PMN with aggregated human IgG. As a result of these experiments it was demonstrated that the increased percentages of PMN with C3R in patients with FS or RA are most likely caused by a previous in vivo activation of PMN by immune complexes. The possible effect of such an increase in C3R expression in relation to PMN function in these patients is discussed.

Antigen-Antibody Complex↗
PubMed1984

Rheumatoid arthritis--the clinical significance of histo- and immunopathological abnormalities in normal skin.

Biopsies of normal skin from 64 patients with rheumatoid arthritis (RA) were studied for histological abnormalities in dermal blood vessels. Thirty percent of patients had a moderate or dense infiltrate of mononuclear cells (predominantly T lymphocytes) around the vessel walls not seen in controls. This infiltrate correlated with disease activity and the presence of extraarticular manifestations. Vascular deposits of IgM often with C3 were seen in seropositive patients only and correlated with the amount of cellular infiltrate. No Ig and C deposits were seen in biopsies of seronegative patients and healthy controls. Apart from IgM and C3, IgG and/or IgA were found perivascularly in the areas of skin with leukocytoclastic vasculitis, indicating participation of other classes of immunoglobulins in immune complexes. The histological and/or immunopathological features that we found in uninvolved skin may serve as markers of disease activity and extraarticular manifestations.

Adolescent↗
PubMed1984

Survival and cause of death in rheumatoid arthritis: a 25-year prospective followup.

In a 25-year prospective followup of 209 patients with rheumatoid arthritis, median life expectancy was shortened by 7 years in males and by 3 years in females when compared with the general population. The surplus mortality was associated in decreasing order with the disease itself, associated respiratory, urogenital and general infections, and with upper gastrointestinal tract disease, mainly bleeding.

Arthritis, Rheumatoid↗
PubMed1983

A synovectomy trial and the history of early knee synovitis in rheumatoid arthritis. A multicentre study.

The results of a randomized synovectomy trial are reported and the history of early knee synovitis in 121 patients with rheumatoid arthritis is described. Conservative treatment (rest in splints, non-steroidal anti-inflammatory drugs and gold or an anti-malaria agent) for 4-5 months led to improvement in 81 of the 121 patients with early knee synovitis. In one-third of these 81 patients, the improvement continued, according to their own and the doctor's opinion, during 5 years of follow-up. Ten of the 22 patients who fulfilled the criteria for the synovectomy trial were operated upon. They showed improvement for 4 years. Over the 5-year period, two-thirds of the group were constantly seropositive or seronegative and in the other third the serology varied, but such that at each assessment 50% of the group were seropositive. Radiologically, all of the patients showed deterioration. The surgical group deteriorated more slowly for the first 2-3 years, but then showed the same pattern as the other groups. The disappearance of the clinical features of synovitis does not mean that radiological deterioration has ceased.

Adolescent↗
PubMed1983

Characterization and classification of lymphoid cells after pokeweed mitogen stimulation.

Human peripheral blood mononuclear cells (PBMC) were stimulated with pokeweed mitogen (PWM) for 3 days and subsequently cultured in medium for another 3 days. It was shown that mononuclear phagocytes (MNP), although present initially in the PBMC cultures, disappeared shortly after the addition of PWM. It was concluded that MNP, although obligatory for stimulation, were no longer required for further transformation of cells after stimulation. At the ultrastructural level stimulation of PBMC with PWM resulted in the generation of 2 types of blast cells. The first type were characterized by the presence of polyribosomes throughout the cytoplasm, large and swollen mitochondria and a few short strands of rough endoplasmic reticulum. The second type of blast cell showed a dispersed pattern of ribosomes, a number of smaller mitochondria and some long strands of rough endoplasmic reticulum. In parallel with a decrease in the number of type I blast cells, plasma cells were found in the stimulated cell cultures. Labeling for surface-membrane immunoglobulins was positive only in type I blast cells and after a longer period in plasma cells. These observations suggest the transformation of type I blast cells into plasma cells, both being derived from the B-cell line. Type II blast cells probably represent transformed cells of the T-cell line.

B-Lymphocytes↗
PubMed1983

The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study.

In a family study, sacroiliitis was found in 15 (25%) out of 61 HLA-B27 positive first-degree relatives (FDR) of 20 randomly chosen HLA-B27 positive ankylosing spondylitis (AS) patients and never in 41 HLA-B27 negative FDR. Eight (53%) of the 15 FDR with sacroiliitis fulfilled the New York criteria for AS. In the population study the prevalence of HLA-B27 positive AS was found to be 0.1%. AS will develop in 1.3% of all HLA-B27 positive individuals belonging to the general population.

Adult↗