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Biomedical subjects

A Castro

Publications and source records attributed to A Castro.

At least 307 records · Page 17Linked to original sources
PubMed1995

Anti-HCMV serologic response in patients with acute viral hepatitis.

The authors point out a high serological incidence of HCMV infection in the course of HCV hepatitis compared to a low incidence detected in HBV and HAV hepatitis. Three immunoglobulin classes (IgG, IgM, and IgA) specific to HCMV were investigated. Antibody titers of each immunoglobulin class are reported for all the cases of HCMV infection.

Acute Disease↗
PubMed1994

Microsomal localization of cyclin A and cdk2 in proliferating rat liver cells.

The expression and intracellular localization of cyclin A and cdk2 have been analyzed in rat liver cells proliferatively activated in vivo by a partial hepatectomy. Western blot analysis revealed that cyclin A started to increase during G1 (at 6 h after hepatectomy) reaching maximal levels during S phase (at 18 h). Cdk2 began to increase during late G1 (at 12 h) peaking also at 18 h. At the latter time cyclin A was mainly localized in the microsomal fraction, although it was also present in cytosol, plasma membrane and nucleus. Active cyclin/cdks complexes containing cyclin A and cdk2 were obtained by precipitation with p13-Sepharose after solubilization of microsomes with triton X-100. The presence of active cyclin A/cdk2 complexes in microsomes was confirmed by immunoprecipitation experiments with anti-cdk2 antibodies. These results suggest a putative role of cyclin A/cdk2 during S phase which would be related with microsomal function.

Animals↗