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Biomedical subjects

A Castells Rodellas

Publications and source records attributed to A Castells Rodellas.

At least 19 recordsLinked to original sources
PubMed1994

Perianal pseudoverrucous papules and nodules after surgery for Hirschsprung disease.

We report two patients with Hirschsprung disease in whom severe diarrhea and a distinctive diaper dermatitis developed after delayed ileoanal anastomosis. The perianal papulonodular lesions cleared in months or years without specific treatment after resolution of the diarrhea. These perianal pseudoverrucous papules and nodules represent a peculiar form of primary irritant diaper dermatitis, distinct from Jacquet erosive diaper dermatitis and granuloma gluteale infantum.

Anal Canal↗
PubMed1992

[Immunology of leprosy. Review of data from the 1980-1990 time period].

The classification used for leprosy so far distinguishes between two polar forms (pauci-bacillary and multi-bacillary), with different influences on the immune cells. The identification of specific antigens of the germ surface with monoclonal antibodies allows finer differentiation in classification, which now extends to transitional forms of clinical relevance. The current status of knowledge about immunological phenomena triggered by Mycobacterium leprae is complex, and controversy is rife at present. The bacillus is comparable to other mycobacteria in antigenicity. Owing to the complicated composition of the cellular envelope, few epitopes are accessible for immunological reactions. Investigation on the behaviour of T-lymphocytes in combination with analysis of the bacterial surface structures led to the development of a new pathogenetic concept. In spite of different immunological and inflammatory reactions in patients (reflecting the individual pathology), the discrimination between a partial and a total immunological defect is made. So far, no histocompatibility-antigen type has been found that allows recognition of the predisposition to infection. Immunity against the bacteria is achieved after BCG in some cases. All this suggests that the development of a vaccine via biotechnical synthesis of idiotypes and anti-idiotypes may be possible.

Humans↗
PubMed1989

[Immunohistochemical study of the distribution of carcinoembryonic antigen and keratin in tumors of epidermal origin. I: Squamous and basal cell epitheliomas].

Carcinoembryonic antigen (CEA) has been studied extensively, in association with visceral tumors and normal tissues. Although CEA has been demonstrated in sweat gland cutaneous tumors, little is known about its presence in skin and epithelial related tumors. We studied the presence of CEA and keratin in squamous cell and basal cell carcinoma using immunohistochemical techniques. Its distribution related with differentiation, proliferation and malignant potential is observed. The expression of both antigens is correlated.

Carcinoembryonic Antigen↗
PubMed1989

[Palmoplantar and disseminated porokeratosis: immunohistochemical study].

We present a new case of porokeratosis plantaris palmaris et disseminata (PPPD), observe in it a histological picture of cornoid lamella in palms, soles, arms, legs and trunk. In this dermatosis, mediant lectins and involucrin to establish keratinocytes alteration. The immunohistochemical studies have reveals not normal formation in the envelope cornea, and fundamentally D-galactose show a marked diminution in the cell membrane.

Adult↗
PubMed1989

[Immunohistochemical study of the distribution of carcinoembryonic antigen and keratin in tumors of epidermal origin. II: Keratoacanthoma and premalignant lesions].

Carcinoembryonic antigen (CEA) has been studied extensively, in association with visceral tumors and normal tissues. Although CEA has been demonstrated in sweat gland cutaneous tumors, little is known about its presence in skin and epithelial related tumors. We studied the presence of CEA and keratin in keratoacanthomas and precancerous skin lesions using immunohistochemical techniques. Its distribution related with differentiation, proliferation and malignant potential is observed. The expression of both antigens is correlated.

Humans↗
PubMed1989

[Differentiation of human epidermis cultured in vitro].

The authors studied human epidermal differentiation in normal skin and skin cultured according to Green's method. No differences was observed except for the filaggrin and involucrin patterns; the lectins revealed identical patterns in normal and cultured human epidermis. The ultrastructural study verified a similar morphology in both types of epidermis.

Cell Differentiation↗
PubMed1989

[Ultrastructural study of a case of argyria].

The authors studied by transmission electron microscopy a case of cutaneous argyria. Found round and oval forms into which there are a silver granules forming rings. Those images sequencied permit hypothesized that the winning of the solved silver by phagocytes into which are precipitate and eliminate out of the cell.

Argyria↗
PubMed1988

[Lectin staining of a Merkel cell tumor].

The authors studied a Merkel's cell tumor with lectins. There is pattern of normal epidermis, but we see the N-acetyl-glucosamine an oligosaccharide not present in epidermis.

Acetylglucosamine↗