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Biomedical subjects

A Carpi

Publications and source records attributed to A Carpi.

At least 145 records · Page 8Linked to original sources
PubMed1978

Evaluation of triiodothyronine (T3) kinetics in normal subjects, in hypothyroid, and hyperthyroid patients using specific antiserum for the determination of labeled T3 in plasma.

Triiodothyronine (T3) kinetics was evaluated using [125I]T3 and the single injection technique; 5 hypothyroid, 6 hyperthyroid patients, and 10 euthyroid control subjects were studied. Plasma-labeled T3 concentration was measured by means of a new method based on extraction of the hormone on Sephadex G-25 columns followed by elution with the specific antiserum. This technique allows a far better separation of the hormonal radioactivity from the labeled iodide produced from T3 catabolism in comparison with the TCA-precipitation-butanol extraction method. The analysis of the experimental data has been performed using non-compartmental treatment (integral approach); results of mono-compartmental analysis of the same data are also reported for comparison. Average metabolic clearance was 15.3 +/- 0.6 (mean + SEM) liters/day/m2 body surface in normal subjects; it was significantly decreased in hypothyroid patients (11.4 +/- 1.1) and significantly increased (33.4 +/- 4.0) in hyperthyroidism. The total plasma equivalent distribution volume was found significantly enlarged in hyperthyroid patients (22.6 +/- 0.9 liters/m2) in respect to that measured in the control group (15.6 +/- 0.4), whereas it was not different from normal value in hypothyroid patients (17 +/- 1.7). Using plasma concentration of native T3, absolute turnover rate and extrathyroidal pool were also estimated; their values were 6.5, 23.7, and 131.7 micrograms/day/m2 and 10.1, 24.2, and 90.6 micrograms/m2, respectively, in hypothyroid, normal, and hyperthyroid groups.

Adolescent↗
PubMed1978

Action of salicylate on failing heart lung preparations of guinea-pig perfused with red blood cells suspended in Tyrode-dextrane.

Heart lung preparations (HLP) of guinea-pig were perfused with homologous red blood cells suspended in 1.5 volumes of Tyrode containing 6% dextrane. Red blood cells were freshly obtained by centrifugation of heparinized blood and subsequent washing with saline. Reduced pulmonary expansion due to bronchoconstriction, increased pulmonary vascular resistance and heart failure rapidly occurred in these preparations. Addition of salicylate to the perfusing medium delayed and attenuated both the respiratory and the cardiac disturbances. A full protection against cardiopulmonary failure was obtained when salicylate was added to the heparinized blood used for red blood cells preparation and to the saline used for red blood cells washing. It is concluded that pulmonary microembolism, due to platelet aggregation, is the primary factor responsible for HLP failure. Bronchoconstriction and pulmonary vasoconstriction are aggravating factors secondary to microembolism. Salicylate appears to prevent the microembolism and the microembolism depending release of broncho- and vaso-constrictor autacoids.

Animals↗
PubMed1977

Reactivity of the cerebral resistance and capacitance vessels and blood-brain water exchange in the experimental brain injury.

In conclusion, an estimate of the intracranial volumetric effects produced in anesthetized dogs by histamine, acetylcholine and CO2 shows that, on a basis of equiactivity on CBF, the effects of histamine on the intracranial content are twice greater than those produced by acetylcholine and CO2. This difference may be explained by a greater activity of histamine on the intracranial capacitance vessels and/or by an increase in the fluid escape from blood to the brain produced by histamine. Data obtained after the production of an acute, cold induced brain lesion support the second possibility.

Acetylcholine↗
PubMed1976

Selective blocking properties of chloro acetyl catechol (CAC) on the alpha-adrenergic receptor.

In anesthetized rats and cats chloro acetyl catechol (CAC, 10 mg/kg i.v. and 10-15 mg/kg i.v., respectively) selectively blocked the arterial hypertensive responses to epinephrine. No adrenergic blockade was produced by CAC in rats pretreated with 20 mg/kg i.p. of the compound 24 hr before the experiment. Norepinephrine-induced contractions of the rat vas deferens and the rat seminal vesicles in vitro were blocked by CAC 10(-4) M. The blockade was prevented by the simultaneous addition of norepinephrine or cysteine. The data are discussed in relation to : (a) the nature of the adrenergic blockade produced by CAC and (b) the possible existence of thiol groups in the vicinity of the active site of the alpha-adrenergic receptor.

Adrenergic alpha-Antagonists↗
PubMed1976

Angiotensin II metabolism and blood pressure in chronic renal disease.

A direct positive correlation has been found between mean blood pressure (MBP) and angiotensin II metabolic clearance rate (AII MCR) (p is less than 0.001) in 12 hypertensive patients with chronic renal disease (CRD) while it is not discernible in nine normals. A strong positive correlation appears between angiotensin II arterio-venous extraction (AII E) and total peripheral resistance in the two groups when analysed both jointly or separately (p is less than 0.001 in all instances). As MBP equals cardiac output (CO) x TPR and AII MCR equals CO x AII E percent, the only parameter which makes the two groups different in the relation MBP/AII MCR is the impairment of CO autoregulation in CRD cases. AII peripheral extraction and degradation is closely linked to the control of peripheral vascular resistance in the two groups.

Angiotensin II↗