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Biomedical subjects

A Carlsson

Publications and source records attributed to A Carlsson.

At least 397 records · Page 22Linked to original sources
PubMed1975

Antagonism by baclophen of the d-amphetamine-induced disruption of a successive discrimination in the rat.

Male rats were trained to performa conditioned avoidance response combined with a successive discrimination in a shuttle-box. The administration of -amphetamine, 4 mg/kg i.p., caused a disruption of the discriminative but not thee avoidance behavior. Baclophen (beta-[-4-clorophenyl]-psi-aminobutyric acid), a GBA-derivative, given in a dose (4 mg/kg i.p.) that had no effect per se on the behavior in this test situation antagonized the -amphetamine-induced hypermotility. The present findins that baclophen antagonized a biochemically induced abnormal behaviour point to an "antipsychotic" action of baclophen in a successive discrimination avoidance test.

Aminobutyrates↗
PubMed1975

Monoamine-depleting drugs.

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2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-↗
PubMed1975

Exposure to methylene chloride. I Its concentration in alveolar air and blood during rest and exercise and its metabolism.

Fourteen subjects were exposed to about 870 and 1,740 mg/m3 of methylene chloride in the air during rest and physical exercise on a bicycle ergometer. The duration of each exposure period was 30 min. Each subject was exposed during four periods. The concentration of methylene chloride in the alveolar air increased in the beginning but had a tendency to level off at the end of each period. There was a high correlation between the alveolar and arterial concentration of methylene chloride. The uptake of methylene chloride was about 55 % of the supplied amount at rest, about 40% at a work load of 50 W, and about 30 and 35 % at 100 and 150 W, respectively. The concentration of carboxyhemoglobin (COHb) increased both during and after exposure. With exposure to 1,740 mg/m3 a concentration of COHb in the blood of about 0.85 g/100 ml was reached. This value corresponds to about 5.5 % COHb.

Adult↗
PubMed1975

Exposure to methylene chloride. III. Metabolism of 14C-labelled methylene chloride in rat.

The accumulation of methylene chloride and its metabolites in different organs and tissues was studied in an experimental series comprising 10 rats. Each rat was exposed for 1 h to radioactive methylene chloride (14C) in a concentration amounting to 1,935 mg/m3 in inspiratory air. Radioactive carbon atoms were found in the isolated carbon monoxide after exposure. There was also a close correlation between the activity of carbon monoxide extracted from the blood sample and the amount of carboxyhemoglobin (COHb) in the specimen. The largest concentration of methylene chloride and its metabolites per gram of tissue was found in white adipose tissue. This concentration had declined by more than 90% 2 h after exposure, whereas the concentration in the liver declined by about 25% during the same period. The amount accumulated in the brain displayed a decline of about 75% 2 h after exposure. Thus the examination showed that the increased concentration of COHb in the blood during exposure to methylene chloride is due to the metabolism of methylene chloride into carbon monoxide.

Adipose Tissue↗