Prolapse of Filshie clips following vaginal hysterectomy.
Explore the source record for details and available documents.
Fallopian Tube Diseases↗
Biomedical subjects
A Carlin
Publications and source records attributed to A Carlin.
Assay for valproic acid and its E-delta2 metabolite in rat plasma by capillary gas chromatography without prior derivatization.
A new and improved gas chromatographic assay method for valproic acid and a metabolite, E-delta2 valproic acid, in rat plasma has been developed. The assay has sufficient sensitivity to measure free levels of the parent drug and metabolite. By employing a Stabilwax-DA capillary column, symmetrical chromatographic peaks were obtained without the need for prior derivatization. Standard curves for valproic acid were linear from 0.1 to 640 microg/ml. Standard curves for the metabolite were linear from 0.1 to 556 microg/ml.
Animals↗
The ars operon of Escherichia coli confers arsenical and antimonial resistance.
The chromosomally encoded arsenical resistance (ars) operon subcloned into a multicopy plasmid was found to confer a moderate level of resistance to arsenite and antimonite in Escherichia coli. When the operon was deleted from the chromosome, the cells exhibited hypersensitivity to arsenite, antimonite, and arsenate. Expression of the ars genes was inducible by arsenite. By Southern hybridization, the operon was found in all strains of E. coli examined but not in Salmonella typhimurium, Pseudomonas aeruginosa, or Bacillus subtilis.
Adenosine Triphosphatases↗
Pancreaticoduodenectomy for recurrent alcoholic pancreatitis associated with microabscesses.
While pancreaticoduodenectomy is reported to be successful in certain patients with symptomatic recurrent or chronic pancreatitis, there are few criteria indicating who will benefit from such an extensive operation. This report consists of a small group of well-defined patients with recurrent episodes of alcoholic pancreatitis who benefited from pancreaticoduodenectomy. The courses of each patient were remarkably similar--recurrent episodes of pancreatitis, weight loss, epigastric pain, intermittent fevers, persistently elevated serum amylase and leukocyte counts, negative blood cultures, intermittent jaundice, failure of endoscopic retrograde cholangiopancreatography and scans showing a persistent mass in the head of the pancreas and biliary obstruction. While no patient had evidence of abscess at elective operation, all had multiple microscopic abscesses, apparently localized to the enlarged pancreatic head. Such localized microabscesses are not necessarily associated with acute clinical deterioration, positive blood cultures, cannulation of the pancreatic duct or pancreatic ductal dilatation. All patients benefited from operation. The presentation of recurrent episodes of pancreatitis associated with persistent enlargement of the pancreatic head and biliary obstruction without relentless progression of jaundice suggests that the patient will benefit from pancreaticoduodenectomy.
Abscess↗
Rapid development of vitamin K deficiency in an adolescent boy receiving total parenteral nutrition following bone marrow transplantation.
In this case report the development of a vitamin K deficiency in a neutropenic adolescent receiving parenteral nutrition following bone marrow transplantation is described. The parenteral nutrition solution did not provide vitamin K and the patient had been receiving oral antibiotics prior to and during use of the intravenous feeding. Oral intake was minimal. Standard adult oral and intravenous multivitamin preparations for use in individuals older than 11 years do not routinely contain this vitamin. The function of vitamin K and causes for development of a deficiency are reviewed. Recommended intakes and guidelines for supplementation are also discussed.
Adolescent↗
The pharmacotherapy-psychotherapy triangle: psychiatrist, nonmedical psychotherapist, and patient.
Members of the Washington State Psychiatric Association (N = 387) were sent a questionnaire asking about their experience with providing adjunctive medicinal treatment to patients in psychotherapy with someone else. Of the 202 respondents, 63% acknowledged such "therapeutic triangles." Younger psychiatrists, psychiatrists working in clinic and/or public settings, and non-psychoanalytic psychiatrists were more likely to participate in such arrangements. It is estimated that between 7200 and 21,000 U.S. psychiatrists participate in such arrangements, with 72,000-210,000 patients seen each month. More extensive study of all aspects of this phenomenon is urged.
Adult↗
Assimilation of new members into problem-solving groups of patients.
Explore the source record for details and available documents.
Adaptation, Psychological↗
Inhibition of systemic inflammation by central action of the neuropeptide alpha-melanocyte- stimulating hormone.
The neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) reduces fever and acute inflammation in the skin when administered centrally. The aim of the present research was to determine whether central alpha-MSH can also reduce signs of systemic inflammation in mice with endotoxemia. Increases in serum tumor necrosis factor-alpha and nitric oxide, induced by intraperitoneal administration of endotoxin, were modulated by central injection of a small concentration of alpha-MSH. Inducible nitric oxide synthase (iNOS) activity and iNOS mRNA in lungs and liver were likewise modulated by central alpha-MSH. Lung myeloperoxidase activity, a marker of neutrophil infiltration, was increased in endotoxemic mice; the increase was significantly less in lungs of mice treated with central alpha-MSH. Intraperitoneal administration of the small dose of alpha-MSH that was effective centrally did not alter any of the markers of inflammation. In experiments using immunoneutralization of central alpha-MSH, we tested the idea that endogenous peptide induced within the brain during systemic inflammation modulates host responses to endotoxic challenge in peripheral tissues. The data showed that proinflammatory agents induced by endotoxin in the circulation, lungs, and liver were significantly greater after blockade of central alpha-MSH. The results suggest that anti-inflammatory influences of neural origin that are triggered by alpha-MSH could be used to treat systemic inflammation.
Animals↗