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Biomedical subjects

A Callis

Publications and source records attributed to A Callis.

12 recordsLinked to original sources

Changes in blood ammonia and lactate levels during a triathlon race.

Blood ammonia and lactate concentrations were analyzed in 7 volunteer male athletes before and immediately after each segment of an endurance triathlon. The purpose of this study was to examine the effects of triathlon on ammonia and lactate blood levels and the possible correlation between both in each different event. Concentrations of blood ammonia were increased after each of the three segments, reaching a peak after the 40 km bicycle ride. Concentrations of blood lactate were also increased over baseline. However, there was a higher increase after the 1.4 km lake swim, than after the 40 km bicycle ride or after the 10 km run. No correlation was found between the levels of ammonia and lactate, suggesting that ammonia and lactate follow different metabolic patterns.

Adolescent

Plasma and red blood cell magnesium levels and plasma creatinine after a 100 km race.

Magnesium homeostasis is critical for exercise performance. In this report the effect of long distance race on the erythrocyte and plasma magnesium concentration is determined in a group of 7 well-trained male amateur runners. After a 100 km race the plasma Mg2+ levels increased significantly from 0.845 +/- 0.074 to 0.934 +/- 0.099 mmol.l-1 (p < 0.05). However, the intra-erythrocyte Mg2+ concentrations were not modified significantly (2.10 +/- 0.2 mmol.l-1 versus 2.14 +/- 0.12 mmol.l-1). Creatinine plasma levels increased significantly from 73.4 +/- 3.5 mumol.l-1 to 117.6 +/- 19.4 mumol.l-1 (p < 0.01), suggesting impairment of the renal function. A significant positive correlation between plasma magnesium and plasma creatinine, r = +0.65 (p < 0.01) was found. These results suggest that an increase in the magnesium plasma levels could be related to renal failure during long-distance running.

Adult

Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man.

An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal in order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique. The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.

Acid-Base Equilibrium

[Effect of a tissue oxygenator (almitrine + raubasine) on the metabolism of 2,3-diphosphoglycerate of rabbits submitted by hypoxia].

In normoxic rabbits, the intravenous injection (1 mg/kg) of the product (almitrine + raubasine) do not modify the erythrocytic level of 2,3-DPG. But, after hypoxia (the rabbits being submitted to an oxygen pressure of 7,8 kPa during 20 minutes) the same dose of this product induce a durable rise of erythrocytic 2,3-DPG level which remain, 24 hours latter, + 15% above normal.

Almitrine

2,3-2, 3-.

Erythrocityc variations of glycolytic intermediates and 2,3-DPG levels in rabbits performing strenuous exercise under hypoxic conditions are correlated with blood pH variations. The hypoxia alone is not able to induce directly an increase of erythrocytic 2,3-DPG level which would facilitate tissue oxygenation.

Animals

[Measurement of differences in oxygen between arteries and veins. Application to the study of cerebral metabolism].

The cerebral metabolic exploration requires a precises measurement of the arterio-venous differences and this, for each metabolite. As far as oxygen is concerned, there are many techniques to measure the blood contents (CaO2 - CvO2). Direct methods give accurate results but their high technicality makes it difficult to adapt them to the increasing medical demand. The authors report the principle and the technique of the indirect method based upon the measurement of the total hemoglobin concentration and the saturation in oxygen. They recall the possible causes of errors, the main of which - induced by an insufficient homogenization of the sample - is (by the way) to be found in both groups of methods although to a lesser degree in the indirect method. Therefore, the latter, that all normally equipped laboratories can carry into practice, seems quite adapted to the "hospital demand" and its validity confirmed by an experience that now belongs to the past.

Arteries