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Biomedical subjects

A Calin

Publications and source records attributed to A Calin.

At least 199 records · Page 11Linked to original sources
PubMed1977

Clinical history as a screening test for ankylosing spondylitis.

A controlled study of 138 subjects demonstrated that the clinical history may be sensitive (95%) and specific (85%) in the differential diagnosis of ankylosing spondylitis when reliance of five specific historic features is made. Back pain that is insidious in onset, in a patient younger than 40 years, persisting for at least three months, associated with morning stiffness and improving with exercise is characteristic of inflammatory spinal disease.

Back Pain↗
PubMed1977

The close correlation between symptoms and disease expression in HLA B27 positive individuals.

Following demonstration that 20 percent of presumed "healthy" HLA B27 positive individuals develop symptomatic ankylosing spondylitis, a controlled follow-up assessment of the remaining "asymptomatic" 80 percent was performed. The clinical and radiological study revealed that there is a close correlation between symptoms and radiologic change in HLA B27 positive subjects; those individuals remaining symptom free have normal pelvic radiographs. Ankylosing spondylitis or "asymptomatic sarcroiliitis" does not exist in a subclinical manner throughout the entire group of B27 positive subjects. Evaluation of the pelvic radiographs of both symptomatic and asymptomatic HLA B27 positive subjects and symptomatic HLA B27 negative controls demonstrated that osteitis pubis and fluffy periostitis are equally distributed among the three groups, only the frequency of sacroiliitis being statistically greater in the B27 positive symptomatic subjects.

Adult↗
PubMed1977

HLA B27 and sacroiliitis in Pima Indians--association in males only.

Since HLA B27 and ankylosing spondylitis are more common in American Indians than other Americans, the association between radiological sacroiliitis (SI) and HLA B27 was examined among the Pima Indians. SI (grade II to IV) was found in 20 per cent of randomly selected Pima adults. B27 was present in 50 per cent of males, but in only nine per cent of females with SI, vs a population frequency of 18 per cent. Among first degree relatives of probands with SI, radiologic changes were found no more frequently than in a randomly selected age matched control series. Uveitis occurred in 18 per cent of the B27 positive subjects, but in only five per cent of the B27 negative subjects (p less than 0.05). B27 was associated with SI and uveitis in Pima males, but no association was demonstrated between B27 and SI in Pima females.

Arthritis↗
PubMed1977

Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of rheumatoid arthritis.

A double-blind parallel multi-centre study of 102 patients with rheumatoid arthritis (RA) was performed, comparing ibuprofen (1200-2400 mg daily) and ketoprofen (150-300 mg daily) a new non-steroidal, anti-inflammatory agent, over a three month period. Ketoprofen was well tolerated and shown to have comparable efficacy with ibuprofen. Longterm efficacy and tolerance studies are indicated.

Adult↗
PubMed1976

An "experimental" epidemic of Reiter's syndrome revisited. Follow-up evidence on genetic and environmental factors.

The relation between a specific infective event (shigellosis), a specific disease entity (Reiter's syndrome), and a specific histocompatibility antigen (HL-A B27) is documented by follow-up study of an epidemic of post-Shigella Reiter's syndrome. Five of the original 10 patients have been traced, HL-A typed, and clinically assessed 13 years after the initial episode. One of the 5 has minimal disease, remains symptom-free, and is HL-A B27-negative. The remaining 4 have followed a chronic course, have persistent active disease, and are HL-A B27-positive. It is estimated that after this single episode of shigellosis, from one sixth to one third of the persons who were HL-A B27-positive developed Reiter's syndrome. The prognosis for postdysenteric Reiter's syndrome must be guarded, especially in the subject who is B27-positive.

Adult↗
PubMed1976

The single hot joint.

Several points may be stressed. (1)When in doubt, perform joint aspiration and look for crystals of micro-organisms. A joint tap is nearly always indicated. (2)Do not rely on a coincidental elevated serum uric acid level. Question the patient regarding drug therapy and other causes of secondary hyperuricemia. (3)Examine all of the patient, looking for tophi (gout), skin lesions (gonococcal infection, psoriasis), erythema nodosum (allergic reactions, fungal infections), and other clues. (4)Monoarticular rheumatoid arthritis is a rare cause of a single hot joint, but it is much more common that the real rarities (e.g., pigmented willondular synovitis). (5)Anky-losing spondylitis and Reiter's syndrome are common, yet frequently overlooked. (6)Radiologic examination is usually not helpful. (7)Having ruled out infection, crystal synovitis, and hemorrhage, it is sufficient to introduce symptomatic treatment and await the natural development of the joint disease. Follow-up in four to six weeks and simple blood studies often reveal the definitive diagnosis. Most of the time, natural healing processes are effective , and reward the patience of the conservative physician. Blind management must always be avoided.

Adult↗
PubMed1975

Striking prevalence of ankylosing spondylitis in "healthy" w27 positive males and females.

Ankylosing spondylitis is diagnosed once or twice in each 1000 males and one tenth as frequently in females, but the true prevalence is unknown. Indentification of genetic marker, HL-A W27, for susceptible persons has provided a tool facilitating epidemiologic studies and allowing identification of "control" populations without the marker. Evaluation by postal questionnaires, and pelvic radiography of 78 HL-A 27W-positive blood donors selected from a group of apparently healthy subjects revealed 14 who satisfied the criteria for definite ankylosing spondylitis. The prevalence was similar in both sexes. One hundred and twenty-six W27-negative controls matched for race, sex, and age failed to yield a single case. For a person of either sex with HL-A W27, there appears to be about a 20 per cent chance that ankylosing spondylitis will develop, suggesting a prevalence of 10 to 15 per thousand. Hitherto accepted figures may underestimate the frequency by a factor of 10 to 20.

Adult↗