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Biomedical subjects

A Calciati

Publications and source records attributed to A Calciati.

At least 73 records · Page 4Linked to original sources
PubMed1986

Heart rate-respiration relationship: computerized method for early assessment of cardiac autonomic damage in diabetic patients.

This study compares the sensitivity of electrocardiographic R-R methods, used alone and with respiration, for diagnosis of cardiac disautonomy in diabetic patients. In 12 diabetic subjects with laboratory signs of neuropathy (45 +/- 10.4 years) (group A), 24 diabetic subjects without neuropathy (45 +/- 11.9 years) (group B) and 16 normal subjects (43 +/- 12.6 years) (group C), electrocardiogram and respiration were on-line digitized during spontaneous breathing and hyperpnea at 3-18 breaths/minute. Heart rate, R-R standard deviation (SD), R-R range (RG) and cross-correlation function (CC) were computed. Reproducibility was tested in 10 normal volunteers (age 22-28 years, mean 25.2). During spontaneous breathing, heart rate was 87.5 +/- 11.8 beats/min in group A, 77.3 +/- 10.8 in group B, and 71.6 +/- 14.9 in group C (p less than 0.05); RG was 102 +/- 51 msec in group A, 166 +/- 78 in group B and 272 +/- 168 in group C (p less than 0.005); SD was 18.2 +/- 10.1 msec in group A, 29.3 +/- 13.7 in group B and 49.2 +/- 26.5 in group C (p less than 0.001); CC was 2.38 +/- 0.66 units in group A, 3.00 +/- 0.72 in group B and 3.85 +/- 0.59 in group C (p less than 0.0001). During hyperpnea the difference between A and B increased for SD, RG (p less than 0.01) and CC (p less than 0.001). CC better discriminates between normals and diabetics without neuropathy during normal breathing; hyperpnea enhances the relationship heart rate-respiration in normal and, at a lesser degree, in diabetic subjects, thus slightly improving the method. The CC method had better reproducibility and lower intersubject variability than traditional methods of R-R variability.

Adult↗
PubMed1986

Automatic on-line measurement of systolic time intervals using a personal computer.

A personal computer-based system for automatically evaluating external systolic time intervals (STI) suitable for practical clinical use is presented. In 56 consecutive unselected subjects, ranging in age from 16 to 77 years (mean = 51 years), the STI recorded with standard technique were computed manually and automatically. Manual and automatic techniques correlated closely in all indices studied (Q-Q interval: r = 0.995; electromechanical systole: r = 0.975; pre-ejection period (PEP): r = 0.985; left ventricular ejection time (LVET): r = 0.973, PEP/LVET: r = 0.981, p less than 0.001). These results demonstrate that automatic evaluation of STI can be effectively made with good reliability using inexpensive hardware.

Adolescent↗
PubMed1985

Disorders of serum electrolytes and renal function in patients treated with cis-platinum on an outpatient basis.

Two hundred and eighty-one patients received 927 doses of cis-platinum, generally on an outpatient basis, at 55 mg/m2 every 3-4 weeks. Mannitol and 2.2501 of hydration with saline and 5% dextrose plus NaCl and KCl were given in 3-4 hr. No case of acute renal failure ensued and when azotemia occurred (3.5% of patients) it was easily reversible and controlled. An abnormal level of one or more electrolytes was detected in 194 patients (69%) during chemotherapy. K+, Na+, Ca2+ and Mg2+ values usually decreased in serum after DDP administration, but their depletion seldom caused symptoms. Hypomagnesemia developed in 20% of patients, but was symptomatic in only 1%. cis-Platinum, at the doses utilized, is safely given to outpatients, with the hydration program employed. Serum electrolyte decrease during chemotherapy must be expected, and rapidly corrected when symptoms develop.

Adolescent↗
PubMed1985

Cisplatin-containing chemotherapy in the treatment of invasive thymoma: report of five cases.

Invasive thymomas are rare neoplasms arising from the epithelial cells of the thymus. In this paper, we report five cases of invasive thymoma treated with cisplatin either alone or combined with etoposide. Two partial responses (lasting 1 and 27+ months from the start of chemotherapy), two minor responses (lasting 1.5 and 13+ months from the start of chemotherapy), and one mixed response were observed. Further studies with cisplatin-containing regimens are warranted in the treatment of this rare tumor.

Aged↗
PubMed1984

Comparison of methylprednisolone and metoclopramide in the prophylactic treatment of cis-platin-induced nausea and vomiting.

Sixty-one patients undergoing treatment with cis-platin-containing regimens were given prophylactically either metoclopramide or methylprednisolone, in order to reduce the gastrointestinal side effects. Vomiting occurred in 79% of the cycles (128/162), and had a distressing intensity in 39.5% of cycles (64/162). No significant differences were observed between metoclopramide and methylprednisolone with respect to number and duration of vomiting episodes and duration of nausea and anorexia. Two of 6 patients benefited from substitution of metoclopramide for methylprednisolone; only 1/11 benefited from the substitution of methylprednisolone for metoclopramide. Metoclopramide and methylprednisolone, at the dosage and schedule used, were well tolerated and moderately active in preventing nausea and vomiting induced by cis-platin; their use in combination could further improve these results.

Adult↗
PubMed1983

Father-son testicular cancer, case report.

A case of familial testicular malignancy in a father and his son is reported. This represents the seventh described case of father-son testicular cancer. The father had seminoma and the son had teratocarcinoma. Both patients' peripheral blood lymphocytes were tested for 52 HLA specificities: the father's antigens were HLA A3, B13, B14, Cw6, Cw8 and the son's were HLA A2, A3, B14, Cw8. (Common haplotype: A3, B14, Cw8). The association between HLA antigens and testicular cancer is discussed.

Adult↗
PubMed1981

Combination chemotherapy for metastatic brain tumors.

Forty-four patients with central nervous system metastases were treated with combination chemotherapy (adriamycin, VM 26 and CCNU). The best results were obtained in breast adenocarcinoma and small cell lung carcinoma with multiple, small cerebral metastases and without concomitant visceral involvement at other sites. The potential effectiveness of this regimen to prevent cerebral metastases is discussed.

Adenocarcinoma↗
PubMed1978

High dose medroxyprogesterone acetate (MPA) treatment in metastatic carcinoma of the breast: a dose-response evaluation.

The results of controlled clinical trial that used high doses of medroxyprogesterone acetate (MPA) in the treatment of metastatic breast cancer are reported. Two treatment reigmens were used: regimen A, 500 mg daily with a total dose of 30 g; regimen B, 1,000 mg daily with a total dose of 60 g. The overall response rates were similar, with no statistically significant difference between the two treated groups. Regimen A (lower dosage group) reached a remission rate of 44%, whereas regimen B (higher dosage group) had a remission rate of 41%. The mean duration of response was 8 months with regimen A and 9 months with regimen B. The advantages of the lower dosage regimen as opposed to the higher dosage regimen of MPA in the treatment of advanced breast cancer are discussed.

Abscess↗
PubMed1976

[Diabetes, obesity and adenocarcinoma of corpus uteri].

Diabetes and obesity were noted in 21.3% and 42.3% respectively of 94 patients with adenocarcinoma corporis uteri. Hypertension and ovarian or mammary neoplasia were also common. Obese and diabetic subjects proved more sensitive to treatment with high doses of medroxyprogesterone acetate. Screening for precancerous states or carcinoma of the endometrium in obese and diabetic women is suggested.

Adenocarcinoma↗