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Biomedical subjects

A C Wicks

Publications and source records attributed to A C Wicks.

108 records · Page 6Linked to original sources

Insulinopenic diabetes in Africa.

The high proportion of unrefined carbohydrates (maize meal) in the diet of Africans could be responsible for their low insulin secretion. The consequent insulinopenia in the general African population may explain the comparative rarity of typical non-insulin dependent diabetes mellitus, and also the virtual absence of coronary heart disease. Changes in growth hormone secretion and in serum lipids, known to be associated with diabetes in Europeans, are also found in African patients.

Adult↗

Management of peptic oesophageal stricture.

Peptic oesophageal stricture develops in approximately 10-15% of patients with inadequately treated reflux oesophagitis and poses a difficult clinical problem. The management of reflux oesophagitis has been revolutionised by improvements in medical management, endoscopic and balloon techniques of oesophageal dilatation. The major advance has been the development of inhibitors of gastric acid secretion: histamine receptor antagonists and H(+) + K(+) + ATPase inhibitors. Studies have recently shown that the H(+) + K(+) + ATPase inhibitor omeprazole is effective in the management of severe resistant reflux disease with peptic stricture formation, leading to a reduction in the number of oesophageal dilatations required by up to 60% of patients. The aim of this article is to review the current medical, endoscopic and surgical management of severe peptide oesophagitis with stricture formation.

Catheterization↗

Assessing dyspepsia in general practice.

The value of the symptom pattern in achieving an accurate diagnosis in dyspeptic disease is still controversial. A number of investigators have used it to distinguish those patients who are at a high risk of serious disease (ulcer or cancer) from those who are not. Such findings have important implications for patient management, both in clinical and economic terms.

Dyspepsia↗