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Biomedical subjects

A C Voss

Publications and source records attributed to A C Voss.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Bone marrow transplantation in patients with leukemia].

Between October 1979 and March 1982, bone marrow transplantations were performed by the Tübingen Group for BMT on 19 patients with acute leukemia in remission and on one patient with chronic myelocytic leukemia in chronic phase. The conditioning regimen consisted of 2 x 60 mg cyclophosphamide/kg and 10 Gy whole-body irradiation with the linear accelerator. The lung dose was limited by shielding to 8 Gy. In 15 patients, the bone marrow cell suspension of the donor was preincubated with antihuman T-cell globulin (AHTCG) for prophylaxis of graft-versus-host disease (GVHD). All patients showed prompt engraftment of donor cells with good hemopoietic function and complete chimerism. Under reverse isolation in sterile units, no severe bacterial or fungal infections were seen in the phase of bone marrow aplasia. Twelve in twenty patients survived between 25 and 900 days. A severe GVHD was seen only in two patients - one after preincubation with AHTCG. One patient died from relapse of his leukemia, another patient had a testicular relapse which was treated with local radiotherapy. Major problems were seen with chronic GVHD (six patients) and infectious complications, most importantly interstitial pneumonia, in the late post-transplant period.

Acute Disease↗
PubMed1982

[Influence of surgery method and post-operative irradiation dose in case of mastocarcinomas (author's transl)].

The authors present the therapy results and side effects of 422 patients who had been submitted to a radical or partially radical operation or to ablatio mammae. The post-operative irradiation was effected under high voltage conditions with doses between 40 and 50 Gy corresponding to the stage. The survival times were not influenced either by the surgery method or by the post-operative irradiation dose. As compared to radical surgery, however, edemas of the arm were significantly less frequent and serious after a less radical operation. No significant increase of recurrences was observed after partially radical operations.

Adult↗
PubMed1981

[The value of radiometry in the treatment planning of inoperable carcinomas of the cervix (author's transl)].

A retrospective study of 731 patients with carcinoma of the cervix in various stages showed that recurrences were most common in patients treated with combined local radium application and irradiation of the parametrium. The basis for radiation treatment planning had been radiometry after the radium application. A comparison of the position of the uterus as shown by this method with computer tomography carried out in 40 patients in the position used for irradiation showed that in more than half these patients there was a significant difference in the results. It therefore appears that it is necessary to determine the position of the uterus by computer tomography in all patients if the applicator deviates from the median line by more than 10 degrees and if the parametrium is not fixed. Frequently it is possible, at an advanced stage, to use a rotational method instead of repeated radium applications.

Brachytherapy↗
PubMed1981

[Prognosis of the bilateral mastocarcinoma (author's transl)].

Between 1970 and 1973, 411 operated patients with mastocarcinomas were post-irradiated according to the stage under high voltage conditions at the Institute of Medical Radiology of the University of Tübingen. At regular intervals, the patients were examined clinically and by means of mammography and other methods of nuclear medicine and radiology in our follow-up department. During a five-year period of observation, 21 patients showed a tumor manifestation in the contralateral breast. These patients have a remarkably unfavourable prognosis. Up to now, only one patient survived five years without symptoms after the therapy of the contralateral mastocarcinoma.

Breast Neoplasms↗
PubMed1981

[Etiology of pericardial effusion following radiation therapy of Hodgkin's disease].

Radiation doses delivered to the anterior pericardium between 1969 and 1979 were ascertained in 16 patients with Hodgkin's disease, in whom pericardial effusions had developed after multiple-field therapy using 5 ventral fixed fields to the mediastinum as a supra-diaphragmatic primary treatment. The appearance of effusions was directly dependent on the dosage, if doses between 53 and 128 Gy had been delivered; in such patients, seriousness of the clinical symptoms was related to the importance of the dose delivered to the anterior pericardium. Control groups consisted of two collectives comprising 9 patients with primary pericardial affection due to Hodgkin's disease, and 11 comparable further patients without complications after mantle treatment; in these collectives, one case in the second group excepted, antisarcolemmal antibodies were not observed. On the other hand, these antibodies could be detected in 5 out of 11 patients with Hodgkin's disease who suffered from pericardial complications following radiation therapy. Possible diagnostic and pathogenetic significance of the present findings is discussed.

Adolescent↗
PubMed1980

[Results of radiation therapy in 214 primary cerebral tumors and 27 metastases to the brain (1969--1978) (author's transl)].

The results of radiation therapy in 241 patients with a cerebral tumor are reported. A total of 214 primary cerebral tumors and of 27 metastases to the brain was irradiated at the medical radiation institute of the University of Tübingen within the period from 1969 to 1978. Of the cases, 56% underwent primary radiation therapy, and 44% postoperative treatment. Histologically verified diagnoses are existing for 68.5% of all the cases. The average survival rate (months) for the different tumor groups--according to the classification of Zülch--is compared with data in literature. The problems concerning the indication of radiation therapy are discussed. The results underline the merely palliative character of actual radiation therapy in the treatment of most cerebral tumors. Its value is to be found in the prevention resp. retardation of recurrences. Irradiation, even palliative irradiation, or cerebral metastases may be recommended without restriction, as special importance has to be attached to the aspect of an improvement of life quality.

Adolescent↗
PubMed1980

[Prognosis of recurrences in case of operated and post-irradiated carcinoma mastitoides (author's transl)].

Between 1970 and 1973, 411 patients suffering of carcinoma mastitoides of all stages were post-irradiated under high-voltage conditions in the Institute of Radiology in Tübingen. These cases were evaluated in order to study the importance of the appearance of a local or regional recurrence. 65 of the patients (= 15,8%) presented recurrences; in 28 of these cases a remote formation of metastases could be diagnosed already before the appearance of the recurrence or at the same time. In 37 cases (=9%) the recurrence was the first and, in the beginning, the only symptom showing a progression of the primary disease. Only a short time later, 30 of these 37 patients were affected with new tumor manifestations. In most of these cases, a close correlation in time can be demonstrated between the appearance of the recurrence and other manifestations of the tumor.

Breast Neoplasms↗
PubMed1980

[Late sequelae of preventive radiation and chemotherapy of the cerebral cranium in children with acute leukemia (author's transl)].

In 15 children, combined treatment of the cerebral crane (irradiation + cytostatics) was done for acute leukemia, using Pinkel's or Riehm's method. In order to judge of late sequelae on the brain tissue, the cerebral crane was explored by means of computed tomography, generally more than a year later. Of 15 children 10 revealed slight or important parenchymal alterations being imputable to the former therapy. A possible augmentation of the sensitivity to radiation due to combined chemotherapy is discussed, and a revisal of therapeutic schedules, therefore, is recommended.

Adolescent↗
PubMed1980

[Irradiation of the breast glands as prophylactic treatment of an estrogen-induced gynecomastia in patients with prostate carcinomas (author's transl)].

One hundred and four patients with histologically demonstrated prostate carcinomas were submitted to a bilateral orchiectomy. Before the beginning of a hormone therapy, both breast glands were irradiated prophylactically. The patients were observed between two and thirty months. The radiotherapy was executed with electrons with an energy of 10 to 12 MeV and by a stationary field which had a size of 10 X 10 cm. A total surface dose of 12,0 Gy was applicated in four single doses of 3,0 Gy each. The symptom-less healing of 45% of the pateints and the rate of only 29% of patients with gynecomastia is considered to be a good result. In view of the success achieved by the hormone therapy, subjective complaints such as hyperesthesia, pains and pruritus are regarded to be less important.

Breast↗
PubMed1980

[Radiation therapy of lymphogranulomatosis: Results under special consideration of recurrences in the early stages (author's transl)].

Absolute 5-year survival rates from 105 primarily irradiated patients with Hodgkin's disease amount to 79% for Stage I and to 88% for Stage II cases. Out of this collective, the patients free from recurrences during 5 years come to a rate of 75% in Stage I and 41% in Stage II. In 37 patients, recurrences were observed, the causes of which are being examined. From the site of the recurrences conclusions may be drawn in view of an improved treatment.

Adolescent↗