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Biomedical subjects

A C Thomas

Publications and source records attributed to A C Thomas.

At least 37 records · Page 2Linked to original sources

Automatic implantable cardioverter defibrillator: surgical approaches for implantation.

Surgical approaches for implantation of the automatic cardioverter defibrillator are sternotomy, left thoracotomy, subxiphoid, and subcostal. Although any one of these may be combined with insertion of one or more of the electrodes transvenously, surgical entry into the chest is required for every noninvestigational defibrillator implantation operation. The approaches differ in exposure provided for selecting electrode sites and for handling untoward events, in amount and location of tissue that must be divided or dissected, and in average time required. The operation is an electrical one. Its purpose is to obtain reliable rhythm sensing so that defibrillation or cardioversion shocks will occur only when necessary, and to obtain low enough defibrillation thresholds for shocks of 30 joules or less to have a 10-joule defibrillation safety margin. Many of the patients have had previous cardiac operations. They usually have low or very low ejection fractions. Intraoperative electrophysiological testing with often multiple defibrillation episodes is required. The choice of approach varies with the state of the patient, the institutional experience, and the surgeon. This article describes technique, and the advantages and disadvantages of the four approaches as used by four surgeons in four different institutions.

Defibrillators, Implantable↗

The postmortem detection of coronary artery lesions using coronary arteriography.

Postmortem coronary angiography was undertaken in 230 hospital deaths from all causes. X-rays before and after decalcification of the intact coronary arterial tree were assessed with regard to the degree and morphology of arterial lesions and extent of calcification. These angiographic appearances were correlated with histological sections following routine paraffin embedding and serial sectioning where appropriate. Stable but patent lesions, characterized histologically by an intact plaque cap and no intraluminal thrombus formation, angiographically revealed a smooth interface between the barium and vessel wall with no filling defect and often an hour-glass configuration. In contrast, patent unstable lesions, characterized histologically by plaque fissuring and intra-intimal or intraluminal thrombus formation, showed an irregular interface angiographically, often with irregular filling defects. Similarly, distinction between an old stable occlusion and a recent thrombotic occlusion could be made angiographically on the basis of smooth or irregular interfaces between barium and vessel wall. Various angiographic appearances are interpreted in the light of the histological morphology encountered and it is concluded that postmortem coronary angiography is an accurate, rapid and invaluable technique in the autopsy investigation of ischemic heart disease and sudden death.

Angiography↗

Membranous nephropathy with graft-versus-host disease in a bone marrow transplant recipient.

A 43-year-old man developed the nephrotic syndrome 26 months after allogeneic bone-marrow transplantation for chronic myeloid leukemia. This occurred during an exacerbation of graft-versus-host disease (GVHD) and both problems remitted after therapy with cyclosporine and prednisolone. Renal biopsy showed ultrastructural and immunofluorescence evidence of membranous nephropathy. Anti-nuclear antibodies (but not antiglomerular or anti-renal tubular epithelial antibodies) were detected in his serum. Experimental GVHD in mice has been associated with immune complex glomerulonephritis and the presence of IgG autoantibodies which has been attributed to abnormal T (donor)/B (recipient) cell co-operation. This association can be extrapolated to the human GVHD where autoantibody formation is better described than immune complex glomerulonephritis.

Adult↗

Operative mortality with implantation of the automatic cardioverter-defibrillator.

Operative mortality was studied in 939 consecutive patients undergoing initial implantation of an automatic implantable cardioverter-defibrillator (AICD) at 15 hospitals. Twenty-nine (3.1%) patients died during the first 30 days after surgery. Among patients who survived beyond the first 30 postoperative days, ejection fraction data were available in 219; compared with the mortality group, these survivors had a significantly higher ejection fraction (34 +/- 15 vs 26 +/- 10%, respectively, p less than 0.001), despite similar age, sex, underlying heart disease, type of presenting arrhythmia and prevalence of concomitant surgery. The causes of perioperative death were sudden in 7 (24%), tachyarrhythmic/nonsudden in 5 (17%), cardiac nonarrhythmic in 9 (31%), and noncardiac in 8 (28%). Twenty-four (83%) of the deaths occurred before hospital discharge, and in all 9 instances of in-hospital sudden and tachyarrhythmic/nonsudden death, the initial recorded rhythm was sustained ventricular tachycardia or fibrillation; in 5 (56%) of these 9 patients the AICD had been in a deactivated state since implantation. Other possible contributory factors in the 12 sudden or tachyarrhythmic/nonsudden deaths included acute myocardial ischemia or infarction in 2 (17%), and "device proarrhythmia" in 3 (25%) that were AICD-related in 2 and secondary to an antitachycardia pacemaker in another; defibrillation threshold testing was not performed in 3 patients (1 of whom had terminal ventricular fibrillation). Thus, in this multicenter experience with thoracotomy requiring AICD implantation, operative (30-day) mortality was 3.1% and correlated inversely with left ventricular ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)

Cohort Studies↗

Pontomedullary tear in a speedboat accident. Report of a case with MRI diagnosis.

A case of atlanto-occipital dislocation with incomplete pondomedullary brainstem tear is reported; it resulted from a high-speed motorboat accident. The 43 year old man exhibited a locked-in syndrome; the diagnosis was made with MRI and verified by autopsy. With modern methods of life support, prolonged survival after such injuries is unfortunately sometimes possible.

Abducens Nerve↗

Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential.

Preservation of rat livers by simple ice-storage has been demonstrated after 24 hr using the University of Wisconsin (UW) solution. Equally good preservation could be obtained by substituting hydroxyethyl starch (HES) from another source or by omission of HES from the UW formulation. Survival, early and late function, and morphology at the end of a 3-month follow-up period were essentially similar for all three test groups. It is concluded that HES is not required for optimum preservation of the rat liver in this treatment model.

Adenosine↗

Evaluation of UW solution in a rat kidney preservation model. I. Effect of hydroxyethyl starch and electrolyte composition.

Preservation of rat kidneys by simple ice-storage has been demonstrated after 48 hr using the University of Wisconsin (UW) solution; hypothermic preservation of the rat kidney was dramatically improved. A modified UW solution without hydroxyethyl starch (HES) also gave uniform survival after 48 hr of storage, and even better function and morphology. Substitution of HES from another source also improved renal function when compared with UW (Dupont) and it is suggested that prolonged storage of UW solution prior to use may reduce its effectiveness. Reversing the Na:K ratio of the solution still allowed successful preservation, but significantly worsened morphology of the surviving kidney.

Adenosine↗

Evaluation of UW solution in rat kidney preservation. II. The effect of pharmacological additives.

The present studies show clearly that both dexamethasone and insulin can be omitted without altering the efficacy of UW. Adenosine and glutathione are both helpful additives, as is allopurinol. These findings suggest an important role of reperfusion injury after preservation, and confirm the benefits of adding pharmacological agents likely to reduce this injury. Cold ischemic damage was significantly ameliorated by UW solution in this stringent model of rat kidney preservation for 48 hr. A substantially simplified modification of UW solution has been shown to give equally effective kidney preservation, after removal of hydroxyethyl starch, dexamethasone, and insulin. Adenosine, glutathione, and allopurinol have been confirmed as helpful pharmacological additives. These findings have defined some of the mechanisms of effectiveness of UW solution and suggest avenues of further exploration to improve simple hypothermic storage and to prevent reperfusion injury.

Adenosine↗

The healing wound: a comparison of three clinically useful methods of measurement.

A variety of different methods can be used to measure healing wounds. Among these are: 1) photographs, with subsequent area quantification using a digitizing pad with computer interface; 2) wound tracings; and 3) a Kundin measuring device. The purpose of this study was to compare three different clinically useful methods of measuring the area of healing wounds. Observations of venous stasis ulcers (n = 36) and decubitus ulcers (n = 37) were made on patients recruited from both inpatient and outpatient populations of a large metropolitan hospital. Analysis of the data using Pearson correlation revealed that all three methods were highly correlated, r = 0.93 or above (p less than or equal to 0.001). However, repeated measures analysis of variance among the three methods revealed that they were all significantly different (p less than or equal to 0.001) from each other. It was concluded that: 1) either of the three methods can be used as a valid index of wound area, but 2) acetate tracing should be used to obtain the most accurate measure of actual wound area.

Adult↗

Factors influencing the presence or absence of acute coronary artery thrombi in sudden ischaemic death.

Sudden ischaemic death results either from an episode of acute myocardial ischaemia consequent upon coronary thrombosis or from an arrhythmia arising within a scarred left ventricle. Very different proportions of these two groups have been reported in both clinical studies in resuscitated subjects with out-of-hospital ventricular fibrillation, and in necropsy series. In 168 cases of sudden death due to ischaemic heart disease coming to necropsy 73 (43.5%) had mural intraluminal coronary thrombi, 50 (29.8%) had occlusive intraluminal thrombi, and 45 (26.7%) had no intraluminal thrombi, giving a ratio of 2.7:1 for those with and without coronary thrombosis. Single vessel disease, the presence of acute infarction at autopsy and prodromal symptoms were positively associated with the presence of coronary thrombosis. Conversely, the presence of old myocardial infarction at necropsy, a known clinical history of ischaemic heart disease and triple vessel disease were associated with the absence of acute thrombosis. The reported variation in the incidence of coronary thrombi in sudden ischaemic death can be largely explained by selection of subjects with those clinical characteristics which are positively or negatively associated with coronary thrombosis.

Acute Disease↗