Adult Hodgkin's disease in Uganda.
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Biomedical subjects
Publications and source records attributed to A C Templeton.
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Sixteen out of 48 adult African patients with Kaposi sarcoma were found to have tumour tissue in lymph nodes. The evidence suggests that there are probably two main types of involvement. One occurs predominantly in younger patients and involves many groups of glands, probably develops in situ, and is associated with a poor prognosis. The other form is the result of metastasis to a node from an aggressive tumour in the neighbourhood. This occurs more commonly in the older patient and carries a much better prognosis than in those with generalised lymphadenopathy, though worse than in patients with nodular disease without gland involvement. Follow-up over a period of many years will be required to discover the outcome in these cases. Kaposi sarcoma is unusual in women but when it occurs runs a more aggressive course than in men.
Five cases of fatal generalized herpes simplex infection in malnourished children are described. This is almost certainly a much more common disease in underdeveloped communities than is at present appreciated. Only a greater awareness of the disease, coupled with full use of histological and cultural methods of diagnosis, will lead to knowledge of its true frequency.A case of neonatal infection, the first recorded in an African, is also described. Reasons are suggested as to why this disease should be seen in malnourished infants in Africa but only very rarely in neonates.
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