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Biomedical subjects

A C Seguro

Publications and source records attributed to A C Seguro.

44 records · Page 3Linked to original sources
PubMedDate not supplied

[Inhibitory effect of serum from rats with acute and chronic renal insufficiency on phagocytic activity in vitro].

The effect of serum obtained from rats with acute and chronic renal failure on phagocytosis was evaluated in macrophages cultured "in vitro". The erythrophagocytosis of these cells was lower after incubation with serum from rats with acute and chronic renal failure when compared to normal plasma. This inhibitory process persisted when the serum was previously filtered through a Millipore filter PM-30, but it was abolished when the serum was filtered through a Millipore filter PM-10. These data suggest that uremic plasma displays a inhibitory factor of phagocytic cells of a molecular weight between 10.000 and 30.000 daltons.

Acute Kidney Injury↗
PubMedDate not supplied

Fatal group A Streptococcal toxic shock-like syndrome in a child with varicella: report of the first well documented case with detection of the genetic sequences that code for exotoxins spe A and B, in São Paulo, Brazil.

A previously healthy seven-year-old boy was admitted to the intensive care unit because of toxaemia associated with varicella. He rapidly developed shock and multisystem organ failure associated with the appearance of a deep-seated soft tissue infection and, despite aggressive treatment, died on hospital day 4. An M-non-typable, spe A and spe B positive Group A Streptococcus was cultured from a deep soft tissue aspirate. The criteria for defining Streptococcal toxic shock-like syndrome were fulfilled. The authors discuss the clinical and pathophysiological aspects of this disease as well as some unusual clinical findings related to this case.

Bacterial Toxins↗
PubMedDate not supplied

[Effect of 9-alpha-fluorhydrocortisone (Florinef) in extrarenal regulation of potassium].

There are evidences that adrenal hormones regulate extrarenal potassium homeostasis. The present study evaluated the effect of Florinef modulation on extrarenal mechanisms in potassium adaptation of adrenalectomized rats. The results demonstrated that the rats treated with Florinef had serum potassium levels at normal range probably due to an increase in cellular potassium uptake consequently to en enhanced activity of Na-K-ATPase.

Adrenal Glands↗
PubMedDate not supplied

[Renal regulation of sodium excretion in experimental heart failure: study of hemodynamics and renal tubular function].

This study was designed to evaluate the role of the kidney on sodium retention in congestive heart failure by clearance and hemodynamic studies. Twenty seven dogs were studied during hydropenia and aqueous diuresis 96 hours after the construction of a bilateral femoral A-V fistula, in 3 periods: 1) with open fistulae; 2) with closed fistulae and 3) with reopened fistulae. The animals retained sodium and water and developed edema during the first period when the fistulae were opened. Closure of the AV fistulae produced an enhanced diuresis and natriuresis associated with an increase in phosphaturia and distal sodium delivery, suggesting a diminished proximal sodium reabsorption. However, when the fistulae were reopened, sodium retention was observed in the presence of an increase in free-water clearance corrected by distal sodium delivery, indicating an increase in sodium reabsorption by distal segments. These findings were not associated with alterations in cortical distribution of renal blood flow. In conclusion, the sodium and water retention in congestive heart failure produced by A-V fistula is due to an increase in sodium reabsorption by the distal nephron segments, and it is not associated to a redistribution of the cortical renal blood flow.

Animals↗
PubMedDate not supplied

[Hyponatremia: study of its epidemiology and mortality].

To determine the prognosis of hyponatremia in an unselected population, we collected clinical and laboratory data and determined the outcome of hospitalization for all hyponatremic patients in a general hospital during a three month period. Fourty-nine episodes of hyponatremia were analyzed. More than 90% of them were observed in hospitalized patients and were of dilutional type, and 34% were classified as severe hyponatremias (Nas less than 118 meq/l.). Diuretics plus salt restriction without water restriction were the main identifiable causes. Neurological disturbances were observed in 10.8% of patients and persisted in 4.3% of then after the treatment. Slow correction of hyponatremia was the treatment used in these patients (0.16 +/- 0.004 meq/l.h). Ten patients died, but in only one case the dead could have been caused by hyponatremia. The results showed that the morbidity and mortality of the hyponatremia is low in our institution, few patients had neurological disturbances and a favorable outcome in all of them was obtained with a slow correction of hyponatremia.

Adolescent↗
PubMedDate not supplied

[Acute nephrotoxicity caused by amphotericin B in the dog].

Amphotericin-B is the drug of choice for the treatment of serious systemic fungal infections. The major limitation for the use of this drug is its potential nephrotoxicity. The chronic and acute administration causes both a reduction of renal blood flow and glomerular filtration rate, determining a fall of renal concentrating ability. Our study was designed to determine the acute effects of Amphotericin-B on dogs renal function, during hydropenia and water diuresis. In addition a hemodynamic study, with the measurement of intrarenal blood flow by the microsphere method was performed. The hydropenic dogs received the drug directly into the left renal artery. There was a significant decrease in creatinine clearance, urinary osmolality, and urinary solute excretion, in the left kidney only. Amphotericin-B was infused into the aorta above the renal arteries in the group in which the water diuresis was induced. This acute infusion produced intense fall in creatinine clearance and in the free water formation, as well as in absolute excretion of sodium. The hemodynamic study showed that the reduction of creatinine clearance may be due to the decrease in renal blood flow, and the alterations in the urinary excretion of water and sodium could not be correlated with the distribution of cortical blood flow to the deep nephrons. These findings suggest that the effects of Amphotericin-B may be attributed, at least in part, to its ischemic action.

Amphotericin B↗
PubMedDate not supplied

[Necrotizing fasciitis. Case report and review of literature].

Necrotizing fasciits (NF) is a rapidly progressive disease characterized by extensive necrosis of the fascia, skin, and subcutaneous tissue, with characteristical sparing of the underlying muscle. It is considered to be a rare entity and is associated with a high mortality rate since early recognition and treatment are not provided. Extensive surgical debridement of all necrotic tissues and appropriate antimicrobial treatment are the cornerstones for a successful treatment. We present a case of NF in a 36-year-old man and discuss it's pathophysiology, clinical manifestations and the best therapeutic choice for this potential life threatening disease.

Adult↗