Changes in labeling pattern of ribonucleic acid from mammary tissue as a result of hormone treatment.
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Biomedical subjects
Publications and source records attributed to A C Peacock.
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Estrogenic hormones induce morphologic and biochemical differentiation in the oviduct of the immature chick. Concomitant with the hormone-stimulated tissue growth, there was an increase in 4S RNA, as judged by polyacrylamide-gel electrophoresis, and a corresponding increase in cellular transfer RNA activity, as measured by the amino acid acceptor capacity. This system may be suitable for studying the relation of hormones to transfer RNA in a differentiating tissue.
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Only a single type of haptoglobin was found in the serum of 11 strains of mice, but there were wide variations between strains with respect to the amount of haptoglobin found. In the AKR and C3H strains, in which haptoglobin was low or absent, various agents stimulated production of high levels of haptoglobin. Serum haptoglobin rose in association with the development of leukemia in AKR mice, but remained low when C3H mice developed mammary tumors.
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