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Biomedical subjects

A C Novick

Publications and source records attributed to A C Novick.

At least 361 records · Page 20Linked to original sources
PubMed1981

Diminished operative morbidity and mortality in renal revascularization.

From 1974 to 1980, one hundred consecutive patients with atherosclerotic renovascular disease underwent revascularization. There were two operative deaths and eight postoperative complications. This low operative morbidity is attributed to preoperative screening, correction of existing coronary or cerebrovascular disease, and reliance on methods of revascularization that obviate operation on a badly diseased aorta. The results in 78 patients with renovascular hypertension were 40% cured, 51% improved, and 9% failed. In 22 patients in whom revascularization was performed to preserve renal function, the postoperative serum creatinine levels were improved in 19 patients, remained stable in two patients, and increased in one patient.

Adult↗
PubMed1981

Management of intrarenal branch arterial lesions with extracorporeal microvascular reconstruction and autotransplantation.

Extracorporeal microvascular reconstruction and autotransplantation have been done on 16 patients with intrarenal branch arterial lesions. The specific indications for this approach and the microvascular reconstructive techniques used in these cases are reviewed. All revascularization procedure were successful. Vascular reconstruction with preservation of renal parenchyma is possible in most patients with extensive intrarenal branch arterial disease.

Adolescent↗
PubMed1981

The role of computerized tomography in renal transplant patients.

We evaluated 53 patients with computerized tomography after renal transplantation. The diagnostic value of computerized tomography scanning was primarily in differentiating between patients with acute rejection and those with obstructive uropathy, urinary fistula or significant perinephric fluid collections. Computerized tomography guidance also may be helpful in performing anterograde pyelography or percutaneous allograft biopsy. The computerized tomography scan provides an effective, non-invasive, complementary method of evaluating post-transplant dysfunction.

Graft Rejection↗
PubMed1981

The value of intraoperative antibiotics in preventing renal transplant wound infections.

In a 3-year period 179 renal transplant operations were performed, during which time a uniform regimen for preventing wound infections was used. The incidence of primary renal transplant wound infections was reduced to 1 per cent by administering a single high dose of broad-spectrum antibiotics intraoperatively as an adjunct to this regimen. Intraoperative antibiotic coverage has been a safe and effective measure for preventing primary transplant wound infections.

Ampicillin↗
PubMed1981

Renal subcapsular hematoma: a diagnostic and therapeutic dilemma.

Subcapsular renal hematomas have been found in 14 hypertensive patients between 17 and 66 years old. In 11 patients with chronic lesions hypertension improved more often with nephrectomy (7 of 7 cases) than with a conservative operation (2 of 4 cases). Non-operative management of acute hematoma resulted in radiographic resolution and improvement of hypertension in 3 of 3 patients. Awareness of the clinical features and judicious use of diagnostic modalities enable proper management of subcapsular renal hematomas in most cases.

Adolescent↗
PubMed1981

Management of end stage polycystic kidney disease with renal transplantation.

Thirty renal transplants have been done in 25 patients with end stage polycystic kidney disease. All but 2 allografts were from a cadaver donor and the average followup was 5 plus or minus 0.9 years. THe 1 and 5-year patient survival rates after transplantation were 76 and 50 per cent, respectively, and allograft survival rates were 63.3 and 39.1 per cent at the same intervals. Of 14 patients at risk for more than 8 years 6 still have well functioning allografts. Nine patients underwent transplantation with both polycystic kidneys in situ and with no adverse sequelae resulting from the retained native kidneys. Despite the risk factors inherent in an older than normal population of cadaver allograft recipients, renal transplantation is an excellent method for treating end stage polycystic kidney disease and holds the prospect for long-term allograft and patient survival rates.

Adult↗
PubMed1981

The current status of surgical therapy for renal artery disease.

The first reports of surgically curable hypertension in the late 1930s led to enthusiasm among clinicians for removing kidneys with arterial stenosis in hypertensive patients. The development of vascular surgical techniques in the 1950s made it possible to achieve successful renal revascularization in many of these cases. However, the cause and effect relationship between a stenotic renal artery lesion and hypertension was poorly understood and many patients treated surgically had no improvement of blood pressure postoperatively. Continued experience in this field during the past two decades has significantly improved our understanding of the natural history and functional significance of renovascular disorders. Patients with renovascular hypertension can now be identified with a high degree of accuracy and successful renal revascularization is possible in most cases. Nevertheless, multiple factors must be weighed in determining whether medical or surgical therapy is more appropriate for a given patient. These include the causal relationship of renovascular disease to hypertension, the adequacy of blood pressure control with medical therapy, the natural history of untreated renovascular disease with particular regard for the risk of sustaining impaired renal function, the medical condition of the patient, the morbidity and results of surgical therapy, and the availability of other therapeutic options such as percutaneous transluminal dilatation.

Adult↗
PubMed1981

Experience with extracorporeal renal operations and autotransplantation in the management of complicated urologic disorders.

Renal autotransplantation with or without an extracorporeal renal operation was performed 45 times upon 43 patients. Twenty-one patients underwent renal autotransplantation as surgical treatment for renovascular hypertension, all of whom are cured or have improved postoperatively. Sixteen renal autotransplants were performed upon 14 patients with extensive ureteral disease, 14 of which were successful. Six patients with carcinoma centrally located in a solitary kidney underwent extracorporeal partial nephrectomy and autotransplantation. Three of these patients are alive with functioning autografts and are tumor-free from one to five years postoperatively. Two patients with multiple recurrent renal calculi were successfully treated by extracorporeal pyelolithotomy and autotransplantation with pyelovesicostomy. An extracorporeal renal operation and autotransplantation can provide the best solution for selected urologic problems not correctable by conventional methods.

Humans↗
PubMed1981

The effect of sterile ureteral reflux on intact and diverted upper urinary tracts.

We studied the effect of sterile ureteral reflux on intact and diverted upper urinary tracts. Five dogs underwent transvesical left ureteral meatotomy and anastomosis of the right ureter to a refluxing ileal conduit. Several normal nonrefluxing renal units were also studied. At 6 months, renal function studies were not significantly different among control, ilealureteral, and vesicoureteral refluxing renal units. No radiographic or histopathologic abnormalities were observed in experimental renal units. Sterile intestinalureteral and vesicoureteral reflux do not seem to cause functional or morphologic renal damage.

Animals↗