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Biomedical subjects

A C Mason

Publications and source records attributed to A C Mason.

49 records · Page 3Linked to original sources
PubMed1992

Value of radiograph audit in an accident service department.

In our accident service department all trauma radiographs are reported acutely and those misinterpreted by the casualty officers are presented at the daily clinicoradiological conference. We have reviewed this practice over a 6-month period. From over 25,000 patients attending the accident service, 16,246 radiographs were requested and reported. Of these, 456 (2.8 per cent) were considered to have been potentially misinterpreted. The errors included 167 (1 per cent) missed fractures, 55 (0.3 per cent) suspected fractures and 72 (0.4 per cent) false-positive diagnoses of fracture. Subsequently, 114 (0.7 per cent) patients required recall for treatment or further imaging. Incorrect diagnoses were seen most frequently in the more commonly injured anatomical sites--the ankle, wrist, foot, elbow and hand. However, the incidence of misinterpretation was highest in examination of the fingers, especially in children. We believe that these low figures are principally the result of involving both orthopaedic surgeons and radiologists at the formal daily conference. We regard our system of audit as beneficial to patients' care and anticipate reduced litigation which may offset the increased cost of audit.

Child↗
PubMed1988

Growth hormone response to growth hormone releasing factor in diabetic men.

Increased plasma concentrations of growth hormone (GH) are reported in diabetes and it is suggested that this may be important in the development of complications. We have investigated fasting GH levels and the response to 100 micrograms i.v. growth hormone releasing factor, GRF(1-29)NH2, in age-matched men: six normal weight controls, six obese controls, six insulin-dependent diabetics, six normal weight non-insulin dependent diabetics and six obese non-insulin dependent diabetics. None of the diabetic men had clinical evidence of diabetic complications. Fasting GH values did not differ significantly between the five groups. The peak GH response to GRF was similar in the controls, insulin-dependent diabetics (IDD) and non-insulin dependent (NIDD) normal weight diabetics (mean peak +/- SEM: controls 25.5 +/- 5 mU/l, IDD 26.5 +/- 6 mU/l, NIDD 19.7 +/- 5 mU/l) but was significantly reduced in the two obese groups (obese 6.4 +/- 3 mU/l, obese diabetics 4.5 +/- 1 mU/l, P less than 0.01). This impairment of GH secretion was unrelated to either fasting plasma insulin or glucose concentration. We conclude that our results do not confirm the previous reports of abnormal GH secretion in diabetes but do demonstrate a markedly impaired GH response to GRF to be a feature of obesity.

Adult↗
PubMed1987

A study of the use of intravenous cannulas for medical emergencies in Newham--implications for financial savings.

A study of intravenous (i.v.) cannula usage for medical emergencies admitted to hospitals in the Newham Health District was undertaken during two defined periods (24 and 35 days). Almost half the cannulas inserted (47%) were not flushed following an initial bolus injection of heparinized saline. The duration that cannulas remained in a vein ranged from 24 hours to 8 days (median 2 days) and inflammation around the cannula site was related to the length of time since insertion but unrelated to whether the cannula was flushed regularly or to the type of fluid used. Our findings indicate a substantial wastage of i.v. cannulas due to difficulties with insertion and suggest that isotonic saline, without heparin, is effective in maintaining cannula patency for 48 hours. It is concluded that these findings are not unique to the Newham Health District and worthwhile financial savings should be achieved throughout the NHS if clinicians reconsider the indications and use of i.v. cannulas for their patients.

Adolescent↗
PubMed1986

Metabolism in rats of selenium from intrinsically and extrinsically labeled isolated soy protein.

Absorption, retention and tissue accumulation by rats of 75Se from intrinsically labeled isolated soy protein were compared with utilization of 75Se from the extrinsic sources of [75Se]selenite, [75Se]selenate or [75Se]selenomethionine. Extrinsic sources of selenium were given by gavage or mixed with isolated soy protein. There were no differences in absorption and retention of 75Se from intrinsically labeled soy diet compared to the three extrinsically labeled soy diets. Of the three extrinsic sources tested, 75Se from selenate was better absorbed than from selenite or selenomethionine when incorporated into a soy diet. Absorption of 75Se was significantly lower when given to animals in gavage solution than when mixed with soy diets. After a 14-d test period, retention of 75Se was the same for all four soy diet groups. In gavaged groups, 75Se from selenomethionine was retained to a greater extent than 75Se from selenite. The liver, testes and kidney accumulated more 75Se from the test meal than did the blood and lungs. In the testes more 75Se from selenite and selenate was accumulated than from selenomethionine-labeled diets. Selenium absorption from the soy isolate source was very high (86-96%), indicating that, although soy does not normally contain high levels of selenium, the selenium present is well absorbed from this plant source.

Animals↗
PubMed1986

Effects of fluctuating skin temperature on thermoregulatory responses in man.

Fluctuations in the skin temperature of volunteers in water, of up to +/- 1.5 degrees C, were induced by circulating water through a tube suit at a fluctuating temperature for 80 min. Fluctuations with a cycle length of 2.5, 5.0 or 10.0 min all slowed the fall in core temperature that otherwise occurred in water at 29 degrees C, and reduced thermal comfort. Metabolic rate increased. Symmetrical fluctuations, or ramp fluctuations with either slow cooling and rapid warming phases or slow warming and rapid cooling phases, were all effective. Similar but less clear effects on core temperature were usually produced by fluctuating skin temperature in water at 25 and 33 degrees C; metabolic rate tended to increase during fluctuation in the 25 degrees C experiments, but not in the 33 degrees C experiments. Stability of the temperature of cutaneous receptors appears to be factor in insidious hypothermia produced by immersion in mildly cool water.

Adult↗
PubMed1984

Radiolabeled iron in soybeans: intrinsic labeling and bioavailability of iron to rats from defatted flour.

Soybeans can be efficiently labeled with radiolabeled iron by supplying the iron via a nutrient culture medium as an iron salt or as a chelate. By using dual labeled iron and EDTA, it was determined that none of the chelator was transported to the shoots with the iron. Therefore, the use of chelated iron as the iron source in the nutrient medium should not affect assessments of bioavailability of iron from plants. Bioavailability (determined from whole-body retention curves of 59Fe in rats) of iron from defatted soy flour was relatively high and addition of vitamin C did not significantly enhance absorption of iron from defatted soy flour.

Animals↗
PubMedDate not supplied

CT appearance of endobronchial non-Hodgkin lymphoma.

OBJECTIVE: Endobronchial involvement by non-Hodgkin lymphoma (NHL) is a very rare manifestation of the disease. We describe this unusual entity and emphasize the role of chest CT scan. MATERIALS AND METHODS: Two radiologists reviewed the chest radiographs and CT scans of two patients with endobronchial NHL. The studies were reviewed for the presence and extent of endobronchial involvement. Bronchoscopic confirmation was obtained. RESULTS: In each case CT showed endobronchial lesions that correlated well with the extent of tumor found at bronchoscopy. CONCLUSION: Computed tomography is useful to suggest endobronchial NHL in the proper clinical context and to assist the bronchoscopist in selecting the appropriate site for biopsy.

Adult↗
PubMedDate not supplied

An infected mediastinal cyst.

The authors describe a 43-year-old patient who had a mediastinal mass that became infected after a transbronchial needle aspirate biopsy. A paraspinal, extrapleural window with a saline-lidocaine mixture was created that allowed the placement of a percutaneous drainage catheter into the infected lesion. This procedure resulted in an excellent clinical outcome, and obviated the need for a thoracotomy and more invasive surgical management.

Adult↗
PubMedDate not supplied

A comparison of learning activity packages and classroom instruction for diet management of patients with non-insulin-dependent diabetes mellitus.

Forty patients were randomly assigned to receive either the individualized learning activity packages or classroom instruction. Effectiveness was evaluated on the basis of fasting plasma glucose, glycosylated hemoglobin, percent of ideal body weight, and knowledge and behavior scores. No significant differences were found between the groups at entry or at the 2-month follow-up. At the 5-month follow-up, the group that received the learning activity packages scored significantly higher on knowledge assessment, significantly increased their behavior score, and decreased their percent of ideal body weight. Patients who received classroom instruction increased their behavior score and exhibited significantly decreased glycosylated hemoglobin levels. Behavior and blood glucose levels were significantly correlated. Although the learning activity packages proved effective in increasing knowledge, no significant improvement was observed in blood glucose levels.

Diabetes Mellitus, Type 2↗