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Biomedical subjects

A C Jain

Publications and source records attributed to A C Jain.

At least 55 records · Page 3Linked to original sources
PubMed1982

Analysis of QT interval in patients with idiopathic mitral valve prolapse.

Analysis of QT interval from repeated recordings was made in 56 patients with documented idiopathic mitral valve prolapse (IMVP). The results were compared with a control of 62 healthy volunteers in whom mitral valve prolapse was excluded by both phonocardiography and echocardiography and with two other standard populations, those of Simonson and co-workers and of Ashman. After correction for age, the maximum QT interval of the patients with IMVP exceeded the 97.5 percentile of Simonson population in 51 of 56 patients compared with only three of 62 subjects of the control group. The difference between the QT interval of patients from the upper limits of the predicted mean values of Simonson was significant (P less than 0.002). The mean QTC interval in patients with IMVP was 0.48 +/- 0.035 second compared with 0.038 +/- 0.025 second in the control subjects. The difference between the mean QTC interval in patients with IMVP and the control subjects was significant (P less than 0.005). Spontaneous prolongation in the mean QT interval was noted in 43 of 56 patients with IMVP (76.6 percent) compared with only two of 62 control subjects (3 percent). The incidence of episodic arrhythmias was 72 percent in patients with marked QTC prolongation (mean, 0.58 second) compared with 22.6 percent in patients with lesser degree of QTC prolongation (mean, 0.46 second). The results suggest that QT abnormality is common in patients with IMVP and may play an important role in the genesis of cardiac arrhythmia.

Adolescent↗
PubMed1980

Noninvasive assessment of left ventricular effects of hydralazine in heart failure.

In order to develop a noninvasive means for following left ventricular responses to hydralazine, we measured the systolic time intervals serially in 6 patients with heart failure. Without affecting heart rate or arterial pressure, hydralazine lengthened the left ventricular ejection time relative to the heart rate (LVETc) 19 +/- 7 msec (p < 0.05) and shortened the preejection period 23 +/- 3 msec (p < 0.001), restoring it to normal in 4 patients. The data suggest that preejection period shortening and LVETc lengthening provide the basis for a noninvasive method of assessing the effects of hydralazine on left ventricular performance in heart failure.

Adult↗
PubMed1977

Left ventricular function after cigarette smoking by chronic smokers: comparison of normal subjects and patients with coronary artery disease.

Twenty normal subjects and 25 patients with coronary artery disease underwent systolic time interval analysis before and after rapidly smoking two cigarettes. A slight increase in heart rate and arterial pressure was seen in both groups. In patients with coronary artery disease, preejection period/left ventricular ejection time ratio increased; in normal subjects it decreased. Left ventricular performance is diminished after cigarette smoking among subjects who have preexisting significant coronary artery disease.

Adult↗
PubMed1975

Myocardial lesions induced by prolonged alcohol feeding in rhesus monkeys.

To elucidate the effects of chronic alcohol ingestion in monkeys a synthetic, adequately balanced, fluid diet providing 40% of total calories from ethanol was gavaged through a stomach tube daily over a period of three months. Clinical, biochemical, radioisotope, and histopathological studies were performed at the beginning and end of the experiment. It was observed that chronic alcohol feeding at this dose level caused maked accumulation of triglycerides, cholesterol, and phospholipids in the serum and the liver. In the heart triglycerides and cholesterol ester were increased. Incorporation studies showed increased synthesis of triglycerides in the heart muscle and liver. Histologically the heart showed fatty change of the myocardium and evidence of focal myocytolysis, atrophy of muscle bundles, and early fibrosis. The liver showed generalized fatty change but no cirrhosis.

Alcohol Drinking↗