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Biomedical subjects

A C Fabian

Publications and source records attributed to A C Fabian.

6 recordsLinked to original sources
PubMed2002

X-rays from active galactic nuclei: relativistically broadened emission lines.

The X-ray spectra of many Seyfert 1 galaxies show an iron-K emission line. Some of these lines are broad and skew, reflecting the rapid motion of the accreting gas together with the deep gravitational potential of the central black hole. The observational evidence for broad iron lines is reviewed, from ASCA to recent Chandra and XMM-Newton spectra. Examples are shown from MCG-6-30-15, for which line variability is discussed. Current results indicate that we are studying accretion flows well within 6GM/c(2).

Journal Article↗
PubMed1999

Active galactic nuclei.

Active galactic nuclei are the most powerful, long-lived objects in the Universe. Recent data confirm the theoretical idea that the power source is accretion into a massive black hole. The common occurrence of obscuration and outflows probably means that the contribution of active galactic nuclei to the power density of the Universe has been generally underestimated.

Journal Article↗
PubMed1982

Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides. Potent nonsteroidal antiinflammatory agents.

A novel series of antiinflammatory agents, N-isoxazolyl-3-carboxamides of 4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide, was synthesized and evaluated as antiinflammatory agents in the carrageenin-induced rat paw edema (CIRPE) assay and adjuvant-induced polyarthritis (AIP) assay. Several analogues were found to be equipotent or more potent than aspirin and phenylbutazone. Structure-activity relationships are discussed. One of the compounds, 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2-benzothiazine 3-carboxamide 1,1-dioxide (3a; isoxicam), was found to be 3 times as potent as phenylbutazone in the CIRPE and in the therapeutic AIP assays. Isoxicam (3a) is presently undergoing phase III clinical trial as an antiarthritic drug.

Animals↗