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Biomedical subjects

A C Brower

Publications and source records attributed to A C Brower.

At least 55 records · Page 3Linked to original sources

Pathogenesis of the neurotrophic joint: neurotraumatic vs. neurovascular.

The most widely accepted and propagated theory of neurotrophic joint pathogenesis is the neurotraumatic one. Seldom published and little known is the neurovascular theory. To gain better understanding of the pathogenesis, we reviewed radiographs of 91 neurotrophic joints with attention to the particular joint affected, the type of changes present (resorptive vs. productive), and the time sequence involved. The pathological findings, when available, were also reviewed. While many joint changes could not be explained on a traumatic basis alone, all could be explained by a vascular mechanism.

Arthropathy, Neurogenic↗

The neuropathic joint: a neurovascular bone disorder.

The pathogenesis of the neuropathic joint has long been a subject of controversy. Two main theories have evolved: (1) the neurotraumatic theory, which states that the changes result from repeated mechanical trauma to a joint that is insensitive to pain, and (2) the neurovascular theory, which states that the changes result from a neurally initiated vascular reflex that leads to hyperemia and very active bone resorption by osteoclasts. Through clinical, radiographic, and pathologic observation, it is evident that both theories play a role. Initially, the alteration of sympathetic control triggers a persistent hyperemia, leading to active bone resorption. There may or may not be secondary pathologic fractures and subsequent repair. This depends upon whether the joint is insensitive and whether it is subjected to continued weight-bearing; if so, then the neurotraumatic mechanism comes into play, but only secondarily.

Arthropathy, Neurogenic↗

Circulatory patterns of deossification.

Bone is a dynamic organ composed of live tissue and inert substance. Thus, an understanding of bone disease has as its foundation the concept of bone as a highly vascular connective tissue in which different nutritional circulatory fields control the deposit and removal of solids in a balanced field. The article offers an explanation of the vascular components of disease and the correlation of anatomically defined nutritional circulatory fields in order to facilitate the necessary breadth and precision of diagnosis.

Acute Disease↗

Computerized measurement and analysis of scoliosis: a more accurate representation of the shape of the curve.

A computer program was created to identify and accept spatial data regarding the location of the thoracic and lumbar vertebral bodies on scoliosis films. With this information, the spine can be mathematically reconstructed and a scoliotic angle calculated. There was a 0.968 positive correlation between the computer and manual methods of measuring scoliosis. The computer method was more reproducible with a standard deviation of only 1.3 degrees. Computerized measurement of scoliosis also provides better evaluation of the true shape of the curve.

Diagnosis, Computer-Assisted↗

Weismann-Netter-Stuhl syndrome: toxopachyostéose diaphysaire tibio-péronière.

Three cases of Weismann-Netter-Stuhl syndrome in nonrelated patients are reported. The classic feature of the syndrome is a congenital anterior bowing of the middiaphyseal part of both tibiae and fibulae. The authors' experience and review of 37 cases reported since its original description in 1954 has revealed a definite association of diaphyseal bowing of other long bones and squaring of the pelvis. The association of mental retardation, goiter, and anemia previously described are felt to be coincidental. At present, this syndrome seems to be some sort of diaphyseal dysplasia, which may be familial or sporadic. The radiographic findings are quite specific and allow easy differentiation of this entity from other disease states: knowledge of this syndrome by the radiologist should prevent unnecessary diagnostic evaluation by the clinician.

Abnormalities, Multiple↗

Bone scans in condensing osteitis of the clavicle.

Two additional cases of condensing osteitis of the clavicle are reported. Technetium Tc 99m phosphate bone scans were positive in both cases. Clinical and roentgenographic manifestations may allow nonoperative diagnoses of this entity which mimics metastatic disease on bone scans.

Bone Neoplasms↗

Rheumatoid nodulosis: another cuase of juxtarticular nodules.

A case of rheumatoid nodulosis and the difficulties encountered in its diagnosis are presented. A positive rheumatoid factor, biopsy proved involvement of the synovium and bone at the second metacarpophalangeal joint, and regression of nodules and mild arthritic symptoms with gold therapy, supported the diagnosis of a rheumatoid disease variant. The relationship of the disease to rheumatoid arthritis, gout, and xanthomatosis is discussed.

Fingers↗

Breast carcinoma.

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Breast Neoplasms↗