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Biomedical subjects

A C Bird

Publications and source records attributed to A C Bird.

At least 271 records · Page 15Linked to original sources
PubMed1984

Recurrences of acute posterior multifocal placoid pigment epitheliopathy.

Acute posterior multifocal placoid pigment epitheliopathy recurred in seven patients (all men, ranging in age from 25 to 43 years). In all seven cases swelling of the pigment epithelium resolved rapidly but left a permanent pigmentary disturbance. Loss of choriocapillaris occurred in six cases. Three patients had severe unilateral visual loss. Three patients had used antimicrobial drugs (two of them repeatedly), suggesting that in some cases this condition may be a manifestation of a hypersensitivity reaction to the antimicrobial agent.

Acute Disease↗
PubMed1984

Vitamin A treatment for night blindness in primary biliary cirrhosis.

Three patients with late stage primary biliary cirrhosis were found to have appreciable night blindness. Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with full recovery of adaptation to dark and visual fields. Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis.

Administration, Oral↗
PubMed1983

Visual prognosis of disciform degeneration in myopia.

A retrospective study was done on a consecutive series of patients presenting to the Moorfields Eye Hospital with visual reduction secondary to angiographically proven subretinal neovascularization associated with myopia (Förster-Fuchs' spot), with a short history of visual loss, and free of other ocular disease. The visual acuity at follow-up was compared to that at presentation, and related to size and location of the neovascular complex, as well as patient age, and duration of follow-up. The results show a generally poor prognosis in that 43% of the patients lost two or more lines of vision, while 60% were less than or equal to 6/60 at last follow-up. As expected there was a direct relationship between visual acuity and the distance of the neovascular tissue from the fovea, and an inverse relationship between acuity and the size of the lesion. There seems to be a short neovascular growth phase, with early visual loss.

Adolescent↗
PubMed1983

Sickle cell retinopathy in Jamaican children: a search for prognostic factors.

Children with homozygous sickle cell (SS) disease and with sickle cell-haemoglobin C (SC) disease, aged 6 1/2 to 8 1/2 years, were examined by fluorescein angiography/angioscopy to determine the presence of retinal nonperfusion. The haematological and clinical features of children with and without nonperfusion were compared. Retinal vessel closure was significantly correlated with low total haemoglobin, and high fetal haemoglobin, reticulocyte, and irreversibly sickled cell counts in SS disease, and with high reticulocyte count in SC disease. No relationships were apparent between vessel closure and other haematological indices or clinical events in either genotype.

Anemia, Sickle Cell↗
PubMed1983

DNA probes in X-linked retinitis pigmentosa.

Informative members of more than twenty families with X-linked retinitis pigmentosa have been sampled by venipuncture and DNA extracted from peripheral blood leucocytes and lymphoblastoid cell lines. X chromosome-specific recombinant DNA probes have been isolated from an X chromosomal genomic DNA library obtained by flow-sorting human chromosomes. These, and similar probes obtained from other laboratories, are being used to identify restriction fragment length polymorphisms in retinitis pigmentosa obligate heterozygotes. By analysis of linkage relationships in the offspring of double heterozygotes, it may be possible to localize the gene(s) responsible for this disorder to a particular subregion of the X-chromosome. Such probes are potentially useful for carrier detection and prenatal diagnosis.

Adolescent↗
PubMed1983

Eales' syndrome.

Explore the source record for details and available documents.

Adolescent↗
PubMed1982

Choroidal ischemia.

Nine patients, seven women and two men, ranging in age from 21 to 86 years, had generalized vascular disease and significant deficits in choroidal perfusion but no retinal vascular changes. Because these perfusion abnormalities can be identified only by fluorescein angiography and the fundus appears to be normal, choroidal ischemia may be more common than has been realized. Infarction of the choroid, retinal pigment epithelium, and outer retina are usually unassociated with retinal detachment; even ischemia severe enough to induce retinal detachment seldom produces significant atrophy.

Adult↗
PubMed1982

Investigation of retinitis pigmentosa.

Retinitis pigmentosa is a solitary manifestation of separate genetically determined disorders in which there is progressive loss of vision and the appearance of characteristic fundus abnormalities. It is likely that each disease contained within this family of disorders has a different aetiology, a consideration which is important to the clinician, the researcher and the therapist. To the clinician it is essential to be able to identify the inheritance of the disorder in order to give educated genetic advice. It is the responsibility of the clinician to sub-divide retinitis pigmentosa into purer samples of disease since without such a sub-division research is unlikely to be fruitful. It is unreasonable to expect a biochemist to define systemic biochemical abnormalities if blood is analysed from a series of patients, each of which has a different disorder. If the cause of retinal degeneration in an animal homologue of human retinitis pigmentosa is identified the question is then raised as to whether the abnormality is relevant to human disease and, if so, to which one. Moreover, if a metabolic abnormality is identified in one disease it will not necessarily to be found in others and similarly, if therapy is effective in one form of the disease it may not be effective for all patients. A sub-division of retinitis pigmentosa may be made on the basis of inheritance of the disorder, on the basis of morphologic changes in the fundus, and on the qualitative functional changes identified. Such observations may also give some clues as to the pathogenesis of the different forms of RP or at least indicate in which cell system the primary disorders lie and will also show in what way the defect interferes with cell function. In this paper it is hoped to show that studies undertaken by the various disciplines within ophthalmology have now made limited achievements towards the goals of subdividing retinitis pigmentosa (RP) into purer samples of disease and typifying the functional and morphological attributes of the constituent disorders.

Dark Adaptation↗