[Behçet's syndrome or Crohn's disease?].
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Biomedical subjects
Publications and source records attributed to A C Baglin.
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Diffuse digestive malakoplakia appears exceptional. A case of rectocolic malakoplakia with multiple localisations is reported in a 22 year old man presenting with inflammatory bowel disease. The most prominent clinical features were deterioration of his general condition, fever, and rectal bleeding, with fistula. Endoscopy revealed pseudotumoral masses and multiple colorectal ulcerations. Diagnosis was based on histological examination of colorectal biopsies. Clinical and histological remission was obtained after colonic diversion associated with broad spectrum antibiotherapy. These findings raise the problem of the possible association between inflammatory bowel disease and malakoplakia. They also confirm that, as previously reported, favourable outcome in digestive malakoplakia is possible.
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An anatomoclinical study is carried out in 11 cases of apparently primary intrahepatic cholestasis. Two groups have been distinguished: one includes three cases with poorly specific and disparate changes. Contrarely, the other group, including eigh cases, shows quite evocative and stereo-typed histological lesions. These are alwayst epithelial and segmental canalar lesions with characteristic cellular infiltrations of variable occurrence and location. The lesions develop into multilating sclerosis with progressive loss of the florid lesions. This group may be assimilated to the affection commonly known as Hanot and Mac Mahon's disease. Antimitochondria antibodies are very often found in this anatomoclinical entity but their absence does not allow exclusion of the diagnosis. Nevertheless, anatomical, clinical and biological correlation remains indispensable.
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