Sulphasalazine in early rheumatoid arthritis.
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Biomedical subjects
Publications and source records attributed to A Burns.
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The medical histories and postmortems of 30 patients with neuropathologically verified Alzheimer's disease were compared with a group of 20 patients suffering from vascular dementia and a group of 10 patients with other forms of dementia. The total numbers of clinically or pathologically diagnosed medical disorders did not show significant differences between the different forms of dementia. Metabolic, infectious, degenerative, and malignant disorders occurred with similar frequency in all investigated groups. Cardiovascular diseases were only slightly more common in patients with vascular dementia. In contrast to several earlier clinical or epidemiological studies, it has to be concluded that patients with Alzheimer's dementia cannot be considered physically "healthier" than patients with other forms of dementia. Therefore, they need the same medical attention as do other elderly demented patients.
We examined the plasma-protein-binding of 67-gallium in 10 patients with probable dementia of the Alzheimer-type (DAT), diagnosed according to NINCDS-ADRDA-criteria, and in 10 healthy controls matched for age (mean: 82 and 83 years) and sex (2m:8f). In comparison to the control group, the percentage of 67-gallium bound in the plasma of DAT-patients was significantly decreased (10.6% vs 15.5%; p less than 0.05). As gallium and aluminum show corresponding biochemical characteristics, these results may indicate a potential contribution of a disturbed peripheral transport in DAT, leading to the intracerebral deposition of neurotoxic aluminum levels.
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Closed wound suction drainage may have application to certain podiatric surgical procedures. It can be used to reduce postoperative edema and hematoma formation, decrease the possibility of infection, and minimize the chance of external contamination of the surgical site. Certain conditions that may occur after podiatric surgical procedures and that are detrimental to the healing and rehabilitation of the patient but can be obviated by the use of closed suction drainage are illustrated. Drains should be considered in any podiatric surgical procedure that results in the creation of large voids or causes substantial bleeding as occurs in large resections of bone. Included in this would be any plastic surgical procedures or amputations of the foot.
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