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Biomedical subjects

A Burette

Publications and source records attributed to A Burette.

At least 55 records · Page 3Linked to original sources

Susceptibility of clinical isolates of Campylobacter pylori to 24 antimicrobial and anti-ulcer agents.

Forty-nine isolates of Campylobacter pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer agents by an agar dilution technique. Penicillin and amoxycillin were the most active drugs (MIC90, 0.06 microgram/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were slightly less active (MIC90, less than or equal to 1 microgram/ml). Moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, paromomycin, metronidazole and tinidazole. All strains were resistant to trimethoprim (MIC greater than 512 micrograms/ml). Nalidixic acid (MIC90, greater than 256 micrograms/ml) and colistin (MIC90, greater than 64 micrograms/ml) had little to no activity. Of four anti-ulcer drugs, only bismuth subcitrate showed activity (MIC90, 64 micrograms/ml). Strains resistant to all 4-quinolones were found in patients who had previously received ofloxacin as part of a clinical trial aimed at eradication of C. pylori. These isolates remained susceptible to amoxycillin, tetracyclines and to other classes of antibiotics.

Anti-Bacterial Agents↗

Campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin.

We randomly assigned 45 adult patients with Campylobacter pylori-confirmed antral gastritis to 8 days of treatment with 1 g amoxycillin suspension twice a day, or placebo, according to a double-blind study design. At the end of therapy, 91% of patients treated with amoxycillin demonstrated clearance of the organism from the antrum, compared with 16% in the placebo group (p less than 0.001). Active antral gastritis resolved in 68% of patients in the amoxycillin group versus only 9% in the placebo group (p less than 0.001). No significant difference was observed when looking at the evolution of chronic only gastritis. No significant improvement was observed in the assessment of clinical symptoms and endoscopic appearance. Reappearance of C. pylori and significant worsening of the histological score of active gastritis was observed after 2 wk in all patients. In a second study phase, 18 patients initially not cleared of their bacteria received amoxycillin single blind for 14 days. Clearance of bacteria associated with improvement or resolution of active gastritis was observed in 72% of the cases. In this subgroup, all patients investigated after 1 month were recolonized with C. pylori and, again, had histological active gastritis. We conclude that amoxycillin is effective in treating active antral gastritis associated with C. pylori, but not in preventing relapses, which occur in all cases within 1 month after therapy.

Adult↗

[Participation of the external carotid artery in orbital vascularization].

The authors present the result of 70 dissections of the arterial vascular system of the orbit. The craniofacial junction is an important location because of possible anastomosis between the two carotid systems. These anastomosis can be situated at the meningeal level, palpebral and also inside the orbit cavity. The embryology of the encephalic vascular supply allows one to explain the possible dual origin of the orbital blood supply. This work shows the frequent participation of the external carotid artery to the orbital vascularisation by mean of three collateral branches: the infraorbital artery, a branch of the maxillary artery, partakes in the arterial supply of the inferior oblique muscle in 85,7% of cases. Usually, the inferior muscular artery which is a branch of the ophthalmic artery also partakes in this supply. In very exceptional cases (2 of 70) the infraorbital artery alone supplies the muscle. the lacrimal artery which can come from the external carotid system either from the middle meningeal artery or from the anterior deep temporal artery. This meningolacrimal artery can be either a solo lacrimal artery (17,14% of cases) or be associated with another classical lacrimal artery, from the ophthalmic artery (11,43%). These lacrimal arteries coming from the external carotid system have the following characteristics: they are thinner than classical arteries, they penetrate the orbit by their own orifice, the Hyrtl canal, and they can participate in the muscular vascularisation, especially of the lateral rectus. When these arteries are unique, most often they are encountered when the ophthalmic artery has undercrossed the optic nerve.(ABSTRACT TRUNCATED AT 250 WORDS)

Arteries↗