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Biomedical subjects

A Brzezinski

Publications and source records attributed to A Brzezinski.

83 records · Page 5Linked to original sources
PubMed1983

Fetal movements and intrauterine growth retardation.

Fetal Movement (FM) rate was evaluated in cases of symmetrical and asymmetrical intrauterine growth retardation (IUGR) and was compared to the FM rate in normal pregnancy. In the 25-36th week of gestation there was a significant decrease of FM rate in both groups of IUGR which was more pronounced in the symmetrical group. Also shown, was a gradual trend of increase of the FM rate with advancing gestational age in both groups of IUGR. Cases of asymmetrical IUGR were noted, who had markedly decreased FM until cessation. In this group of IUGR decreased FM demands prompt hospitalization and fetal heart rate monitoring so that possible respiratory failure and impending fetal death can be detected.

Female↗
PubMed1982

Post appendectomy mechanical sterility.

The incidence of female sterility due to pelvic adhesions following appendectomy was evaluated. Two groups of women were investigated: the first group consisted of girls who underwent appendectomy under the age of ten. Of this group, we were able to detect 24 women of whom 9 were still single and 13 have delivered one or more children. The second group was selected from women in whom mechanical sterility was confirmed by laparoscopy or laparotomy. The rate of appendectomy in this group was found to be 29 percent compared to 7-10 percent in the general population. Seventy one percent of the women who underwent appendectomy were above the age of seventeen when operated. It is concluded that women undergoing appendectomy, particularly after adolescence, are at higher risk for subsequently developing mechanical sterility.

Adult↗
PubMedDate not supplied

Use of old and new oral 5-aminosalicylic acid formulations in inflammatory bowel disease.

Although sulfasalazine, a 5-aminosalicylic acid (5-ASA) agent, is still the anti-inflammatory agent of choice for ulcerative colitis and Crohn's disease, newer formulations, which release drug to specific regions of the colon for maximal efficacy, also can be appropriate first-line agents. This article reviews recent clinical studies of therapy with older and newer 5-ASA formulations.

Administration, Oral↗
PubMedDate not supplied

Management of menopause in women with breast cancer.

It is now well established that replacement therapy with estrogen is an effective tool to manage menopausal symptoms. There is also increasing evidence that hormone replacement therapy has beneficial effects on the long-term consequences of estrogen deficiency, such as osteoporosis and ischemic heart disease. However, breast cancer patients have been traditionally denied the beneficial effects of hormone replacement therapy (HRT) because of the belief that renewed hormonal exposure would accelerate the growth of occult breast cancer or facilitate breast carcinogenesis. Based on new data and reanalysis of old data, a reappraisal of this belief has recently been proposed. Reports on a small number of patients who did receive HRT with no apparent effect on their breast disease warrant large-scale prospective studies on this issue. Meanwhile, pharmacological and "natural" alternatives to hormonal treatment are also available for breast cancer patients.

Breast Neoplasms↗
PubMedDate not supplied

The pattern of serum melatonin levels during ovarian stimulation for in vitro fertilization.

OBJECTIVE: To characterize the relationship between the pineal gland hormone, melatonin, and gonadal hormones. METHODS: We studied the pattern of serum melatonin at the time of ovarian stimulation for in vitro fertilization. Blood samples were obtained every morning, from 20 healthy women during the in vitro fertilization cycle. RESULTS: A progressive rise in serum estradiol and prolactin was noted in all IVF cycles, while serum melatonin levels remained unchanged throughout the cycles. In two of the subjects the circadian rhythm of serum melatonin was assessed at 4-hour intervals for 24 hours. In both subjects the melatonin rhythm was remarkably consistent in terms of phase, amplitude, and total melatonin secreted during the treatment cycles. CONCLUSIONS: These results indicate that endogenous estradiol, progesterone, and prolactin do not affect the levels or circadian phase of melatonin secretion in humans.

Adult↗