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Biomedical subjects

A Brown

Publications and source records attributed to A Brown.

At least 739 records · Page 41Linked to original sources

Discharge functional capacity and self-efficacy of men after coronary artery bypass graft surgery.

Fatigue and activity intolerance are reported to persist for several weeks after discharge after coronary artery bypass graft (CABG) surgery. This may be due to early discharge, which limits the time, prior to leaving hospital, to achieve an adequate functional level for the performance of many activities of daily living. Alternatively, it may be related to level of self-confidence, or self-efficacy (SE), in one's ability to perform physical activity. High SE may result in overexertion during the vulnerable, early post-discharge phase of recovery, whereas low SE may cause underexertion. The limited number of cardiac rehabilitation programs in Canada for this phase of recovery precludes close guidance and monitoring during physical activity for most patients. Prior to prescribing safe and effective home exercise at discharge, it is essential to assess functional level, cardiovascular responses to physical activity, and perceived level of confidence in ability to perform physical activity. The purpose of this descriptive study was to measure functional capacity, hemodynamic responses to low level exercise, and self-efficacy at discharge after CABG surgery. Twenty-one men completed a self-efficacy questionnaire (SEQ) and a low-level graded exercise test (LL-GXT) using a modified Naughton protocol, on the day of discharge. Results revealed that discharge functional capacity ranged from 1.0 METs to 4.3 METs, peak heart rate ranged from 82-150 beats.min-1, and peak systolic blood pressure from 114-200 mmHg. Subjects were more confident in their ability to tolerate psychological stressors than physical activity. Furthermore, there was no correlation between SE for physical activity and the physiological variables except HR.(ABSTRACT TRUNCATED AT 250 WORDS)

Activities of Daily Living↗

UV radiation and cancer prevention: what is the evidence?

The health benefits of sunlight and the risk of skin cancer from UV exposure are still controversial. The literature was analyzed in terms of reviews, controlled and epidemiological studies for the relationships between sunshine exposure and overall cancer mortality, as well as mortality from cancer of the prostate, colon and breast. The residential and/or occupational sun exposure rate seemed to be positively correlated with a lower risk of overall morality due to organ cancer. A normal vitamin D status appeared to be an important precondition, via the local and autocrine synthesis of 1,25(OH)2D3 in the target tissues. The vitamin D hormone system is necessary for cell proliferation and differentiation; different types of vitamin D receptor gene polymorphism seemed to be associated with cancer cell growth. The health benefits of sunlight appear to outweigh the risk of skin cancer. However, the optimal UV exposure, the target level of circulating vitamin D, and whether vitamin D is the only pathway are still undetermined.

Breast Neoplasms↗

Depression in black women of low socioeconomic status: psychosocial factors and nursing diagnosis.

This study examines the relationship between depressive symptomatology and selected psychosocial variables in a sample of low socioeconomic status of Black women. The purpose of the investigation was to determine if a study of attribution style, interpersonal style, and racial identity within this sample of Black women might yield results that would lead to the development of treatment strategies with specific applicability to this population of people. Findings indicated a significant disproportionate prevalence of depressive symptomatology in sample of 101 Black women.

Adolescent↗

After birth.

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Drug Evaluation↗

H-77: a potent new renin inhibitor. In vitro and in vivo studies.

Chemical modification of the backbone at the cleavage site in the (6-13)-octapeptide of equine angiotensinogen resulted in greatly increased binding affinity and resistance to cleavage by renin. The D-His6-Tyr13 octapeptide analog containing the reduced bond -CH2-NH-instead of a peptide bond -CO-NH- at the Leu10-Leu11 linkage (H-77) was a powerful in vitro inhibitor of canine renin (IC50 = 24nM). It gave an IC50 of 1 microM against human renin and 0.6 microM against rat renin. In sodium-depleted conscious dogs, infusion of H-77 caused dose-related falls of plasma angiotensin I plasma angiotensin II concentration and mean arterial pressure; the minimum effective dose was 0.1 mg . kg-1 hr-1. Similar infusions of H-77 in chronically catheterized rats have no effect on blood pressure or plasma angiotensin II concentration. Thus, the in vitro effect of H-77 as an inhibitor of renin in dog, human, and rat plasma was paralleled by its action in the whole animal.

Angiotensin I↗

The role of DEXA bone densitometry in evaluating renal osteodystrophy in continuous ambulatory peritoneal dialysis patients.

OBJECTIVE: The aims of this study were to assess the clinical utility of total and regional bone densitometry in a large continuous ambulatory peritoneal dialysis (CAPD) population and to determine the clinical, biochemical, and radiographic variables that best identified osteopenic CAPD patients. DESIGN AND PATIENTS: A cross-sectional study was performed on 45 CAPD patients (19 males, 26 females), comprising the total CAPD population at the Princess Alexandra Hospital. MAIN OUTCOME MEASURES: Total body (TB), anteroposterior lumbar spine (APL), femoral neck (FN), Ward's triangle (WT), and skull bone mineral densities (BMDs) were measured using dual-energy x-ray absorptiometry (DEXA) and then correlated with clinical, biochemical, and radiographic indices of uremic osteodystrophy. RESULTS: BMDs were not significantly different from age- and sex-matched reference population data. Considerable regional variation of BMD Z scores were noted between FN (-0.11 +/- 0.23), WT (-0.11 +/- 0.22), and APL (1.22 +/- 0.04) (p = 0.003). APLZ scores were significantly reduced in patients with a previous history of fracture (-1.36 +/- 1.07 vs 0.89 +/- 0.31), bone pain (-0.72 +/- 1.08 vs 1.01 +/- 0.31), or steroid treatment (-0.62 +/- 0.39 vs 1.16 +/- 0.35). Increased BMD Z scores for APL (1.82 +/- 0.57 vs 0.38 +/- 0.29, p < 0.05), FN (0.32 +/- 0.36 vs -0.38 +/- 0.29, p = 0.014), and WT (0.45 +/- 0.38 vs -0.45 +/- 0.26, p < 0.05) were found in patients with radiographic hyperparathyroid bone disease. Both APL BMD Z scores and skull BMDs were weakly correlated with PTH (r = -0.33, p < 0.05 and r = -0.33, p < 0.05, respectively) and with CAPD duration (r = 0.30, p < 0.05 and r = -0.30, p < 0.05). Generally, however, total body and regional BMDs were poorly related to age, renal disease type, dialysis duration, renal failure duration, serum aluminum, calcium, phosphate, alkaline phosphatase, osteocalcin, and parathyroid hormone. CONCLUSIONS: We conclude that the prevalence of osteopenia is not increased in CAPD patients. Clinical and biochemical parameters do not reliably predict BMD measurements, but prior steroids and bone symptoms are major risk factors for important bone loss. Although DEXA can reliably detect osteopenia in different skeletal regions, its usefulness in detecting osteodystrophy is limited by the confounding effects of superimposed hyperparathyroid osteosclerosis, which increases BMD.

Absorptiometry, Photon↗