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Biomedical subjects

A Brodish

Publications and source records attributed to A Brodish.

42 records · Page 3Linked to original sources
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Gender and chronic stress effects on the neural retina of young and mid-aged Fischer-344 rats.

Young (5 months) and mid-aged (11 months) male and female Fischer rats were exposed to daily (5 days/week) chronic escapable foot-shock stress for 6 months. Following a subsequent 1-month rest period, by which time the animals were 12 and 18 months old, neural retinas were evaluated histopathologically and morphometrically. A significant reduction in the thickness of the retina occurred in the mid-aged, as compared to the young animals. A severe age-related loss in photoreceptor cells, particularly in the peripheral zones of the retina, occurred in a pattern resembling that described for aging humans. The effect of stress was to increase photoreceptor loss in a pattern resembling that of age-related cell loss. Stress-associated photoreceptor cell death was observed in males and females of both ages, but was more pronounced and statistically significant for mid-aged males (a five-fold increase in cell loss over females). The results demonstrated that exposure of rats to chronic escapable foot-shock stress exacerbates retinal changes commonly associated with aging and that the deleterious effects of chronic stress exposure were greater in the older age, male group.

Aging↗
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Substance P and somatostatin content and transport in the vagus and sciatic nerves of the aging Fischer 344 rat.

The two widely distributed neuropeptides, substance P (SP) and somatostatin (SS), are synthesized in cell bodies of the sensory ganglia of the vagus and sciatic nerves and transported bidirectionally toward the central nervous system and sites of sensory innervation. In this study, the content of both peptides was measured in the vagus and sciatic nerves of Fischer 344 rats aged 4, 12 and 25 months. In addition, as an indicator of biosynthesis within the sensory ganglia, the quantity of neuropeptide transported during 22 hours in a peripheral orthograde direction was measured using the ligation technique in animals age 12, 18 and 25 months. The content and transported quantity of SP was unchanged or slightly increased in both nerves as a function of age. Somatostatin content was unchanged and transport increased in the vagus of older rats. In contrast, in the sciatic nerve, SS content was reduced by more than 30% in older rats (p less than 0.01); transported somatostatin was proportionately reduced (p less than 0.05). These findings demonstrate that neuropeptide levels in the sensory vagus are not reduced as a function of age. Somatostatinergic dorsal root ganglion neurons may be selectively vulnerable in the aging Fischer rat.

Aging↗