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Biomedical subjects

A Brandberg

Publications and source records attributed to A Brandberg.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Comparison between sterile saline and tap water for the cleaning of acute traumatic soft tissue wounds.

OBJECTIVE: To find out if there were any differences in infection rates if acute traumatic soft tissue wounds were cleaned with tap water instead of sterile saline. DESIGN: Randomised study. SETTING: Emergency department at one city hospital. SUBJECTS: 705 consecutive patient with soft tissue wounds less than six hours old that did not penetrate a viscus, cavity, or joint and could be treated by primary suture. INTERVENTIONS: Randomly allocated to have the wound cleaned with either sterile saline or tap water in addition to debridement. MAIN OUTCOME MEASURE: Rate of wound infection, the presence of which was indicated by pus in the wound and prolonged healing. RESULTS: The infection rate in wounds cleaned with sterile saline was 10.3% compared with 5.4% in wounds cleaned with tap water (p less than 0.05). Infected wounds were significantly larger than uninfected ones (p less than 0.05) and more likely to be located on a lower extremity (p less than 0.05). There were no microbiological differences between the two groups, and no bacterial species grown from tap water was subsequently grown from an infected wound. CONCLUSION: Sterile saline should be replaced by tap water for the cleaning of acute traumatic superficial soft tissue wounds.

Acute Disease↗
PubMedDate not supplied

Systemic prophylaxis with doxycycline in intestinal surgery on patients with high incidence of abnormal fecal flora.

Resistance of the fecal bacterial flora to doxycycline was studied before, during and after systemic prophylaxis with that agent in 24 patients undergoing surgery for complex intestinal disorders, 14 of whom had received antibiotics during the preceding 6 months. Fecal specimens for bacteriologic culture were obtained preoperatively, at operation and 3 days, 1 week and 4 weeks postoperatively. In nine patients (38%) there was dominance of doxycycline-resistant strains preoperatively. At 3 days and 1 week postoperatively the corresponding figures were around 55%. Dominance of doxycycline-resistant bacteria was found in altogether 20 patients at some time during the 4 postoperative weeks. At 4 weeks the fecal flora was normal in 22 of the 24 patients. Antibiotics other than doxycycline should be preferred for prophylaxis in patients undergoing complex, revisional or repeat bowel surgery, especially if they have received antibiotic treatment in the preceding 3-6 months.

Adolescent↗
PubMedDate not supplied

Diagnosis of small intestinal bacterial overgrowth in clinical praxis: a comparison of the culture of small bowel aspirate, duodenal biopsies and gastric aspirate.

BACKGROUND/AIMS: This study was undertaken to validate the usefulness of the culture of duodenal biopsy specimens and gastric aspirate compared to the culture of small bowel aspirate for diagnosing small intestinal bacterial overgrowth. We also investigated the occurrence of predisposing conditions in these patients. METHODOLOGY: Seventy five consecutive patients, admitted because of symptoms which caused us to suspect small intestinal bacterial overgrowth, were studied. For all patients, specimens for the culture of small bowel aspirate, duodenal biopsies and gastric aspirate were obtained during upper endoscopy. RESULTS: Eighteen patients showed growth of gram negative bacteria, 22 growth of gram positive bacteria and 35 showed no significant growth in cultures of small bowel aspirate. Cultures of duodenal biopsies revealed gram negative bacteria in 11 patients, gram positive bacteria in 9 and no growth in 55. Cultures of gastric aspirate revealed gram negative bacteria in 7 patients, gram positive bacteria in 12 and no growth in 51. Ten of the 18 patients with gram negative overgrowth and 13 of the 22 patients with gram positive overgrowth had a predisposing condition. In contrast, only 4 of the 35 without overgrowth had a predisposing condition. CONCLUSIONS: The culture of duodenal biopsy specimens or gastric aspirate is a less sensitive method than the culture of small bowel aspirate. Most patients with culture-proven small intestinal bacterial overgrowth had at least one predisposing condition.

Adult↗