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Biomedical subjects

A Brachet

Publications and source records attributed to A Brachet.

At least 37 records · Page 2Linked to original sources

[A "non-narrowing" patch using the superior thyroid artery in surgery of carotid arteries].

It seems to be generally agreed that a closing patch is necessary after carotid endarterectomy. The materials utilized (prostheses or veins) having their own morbidity, we prefer to use a piece taken from the superior thyroid artery; Satisfactory results were obtained in the first 26 cases. This autologous biological material has the advantage of being an arterial structure (therefore compatible with the sutured artery) which is obtained in situ and spares the venous system.

Arteries↗

[Treatment of fractures of the floor of the orbit with a double approach. Apropos of 30 cases].

Orbital floor fractures present an urgent motive for consulting both the ophthalmologist and the ENT surgeon. A complete surgical exploration, with a double approach, allows manual and visual control. Therefore, the floor is repaired in the best conditions with the use of a graft from the anterior wall of the maxilla. Thirty cases are presented here with a follow-up of three to five years. The object of this study is to show the necessity of cooperation between the ENT surgeon and the ophthalmologist, and the advantages of the double-sided approach. The technique gives an excellent view of the lesion, allows a sound anatomical repair with a graft taken through a Caldwell-Luc approach. On the whole, the results of this series, started in 1976, are very satisfactory.

Adult↗

[Measurement of the blood levels of antiepileptic drugs. I. General principals].

The authors report some basic notions on the pharmacokinetics of antiepileptic drugs, and the informations given by serum level determinations of anticonvulsants. It is not conceivable to treat epileptics without taking into account these facts. But it is neither necessary nor desirable to measure blood levels of antiepileptic drugs in every patient.

Anticonvulsants↗

Concentration of dipropylacetate in plasma.

Dipropylacetate is absorbed rapidly and attains a maximum concentration in serum 1 to 3 hr after ingestion. Since its half-life is on the order of 8 to 10 hr, it must be prescribed three times a day, every 8 hr. It reaches a stable concentration in blood within 48 hr after treatment is begun (by contrast with diphenylhydantoin and phenobarbital) and might therefore be useful when seizures must be controlled quickly. The serum concentration can be altered by some other anticonvulsant drugs, but these interactions should be studied in more detail. The serum concentration varies considerably in the course of a day and from one day to the next in the same subject, which makes it difficult to adjust the blood level. Depamide is rapidly transformed in vivo to dipropylacetate.

Administration, Oral↗