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Biomedical subjects

A Bourrillon

Publications and source records attributed to A Bourrillon.

At least 73 records · Page 4Linked to original sources
PubMed1992

Effectiveness of the daily record review at the medical emergency room department in a French teaching children's hospital.

We evaluate the effectiveness of the daily record review (DRR) of 4393 ambulatory medical patients seen at the emergency room department of a teaching pediatric hospital in Paris between 8th January and 11 March 1991. For these patients, 137 potential quality problems were found, 117 of them remaining after discussion with the junior. For 80 of the 117 confirmed problems (68.4%), the reviewing senior estimated that sufficient advice had been given to the child's usual caretaker or health care provider and (or) the children returned to seek medical advice when indicated. Experts proved the procedure to be reliable: they detected a problem for 36% of the cases with potential quality problems and for only 2% of a sample of control records considered without potential quality problems after the DRR.

Emergency Service, Hospital↗
PubMed1992

[Allergy: the pressing need for public education].

Data collected using a self-questionnaire filled out by the families of 294 children under 12 years of age seen in a pneumoallergology clinic showed widespread lack of information on the role of environmental factors in allergic diseases. Parents ascribed their child's disease to the environment at home only when they were dissatisfied by their housing conditions. Parents who were satisfied with their home failed to perceive that indoor factors with detrimental effects may nevertheless be present. This lack of information was seen across the spectrum of enrolled patients, including in those with hypersensitivity to house mites. The need for health education of the public at large aimed at promoting preventive strategies is underlined.

Allergens↗
PubMed1992

[The association of pulmonary hemosiderosis and celiac disease. Apropos of a new case in a child].

A new case of pulmonary hemosiderosis with coeliac disease is reported. This is an extremely rare combination of which only nine instances have been published over the last 20 years. Three of the reported cases occurred in children. Apart from a marked predominance of males, the combination has no specific features. Firm evidence of a causal relationship between the two diseases is lacking but treatment with a gluten-free diet alone apparently had beneficial effects on the lung disease in two patients. Three pathogenic hypotheses are discussed herein: deposition of circulating immune complexes involving food allergens on the basement membrane of alveolar capillaries; reaction between antireticulin antibodies and an alveolar basement membrane antigen; or effect of adenovirus 12, a potential causative factor for celiac disease. Patients with idiopathic pulmonary hemosiderosis should routinely have tests for gluten intolerance, for instance a lactulose-mannitol intestinal permeability test. Lastly, other concomitant food allergies are reported.

Celiac Disease↗
PubMed1990

[Rheumatism and acne conglobata . Apropos of a new case, in a 13-year-old boy].

With reference to a new case of acne conglobata-associated rheumatic disease in a thirteen-year-old boy, we recall the characteristics of the main joint and/or bone manifestations that may occur during severe flares of acne conglobata, but also acne fulminans or pustulosis of the palms and soles. Joint manifestations mainly involve the large proximal joints of the limbs and consist in pain rather than in signs of inflammation. Although recurrences may develop, joint disease responds to treatment of the acne combined with a non-steroidal antiinflammatory drug. Bone involvement consists in true rheumatic osteitis with hyperostosis responsible for densification and thickening of bone, mainly in the anterior chest wall and spine. The pathogenesis and nosologic place of these bone and joint manifestations remain controversial: they do not seem to represent true reactive arthritis and, although the B27 antigen is usually lacking, they have been likened to the group of spondylarthropathies, especially in those cases with sacroiliac involvement and enthesopathy . Oddly enough, they are reminiscent of some of the side effects of etretinate, an agent prescribed in these severe forms of acne. After a national survey carried out in 1986, the acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) was suggested to designate the range of skin, bone and joint manifestations observed.

Acne Vulgaris↗
PubMed1989

[Kawasaki syndrome].

Recent studies support the hypothesis that Kawasaki disease is due to a hyperimmune vasculitis, probably of infectious origin. In addition, current data highlight the frequency of atypical (oligosymptomatic) aspects of the disease which may not be recognized, thereby worsening its cardiovascular prognosis. The types of cardiac lesions encountered, notably those of the coronary arteries, have now been well established by sequential echocardiographic studies. Several therapeutic trials have confirmed the effectiveness of gammaglobulins (400 mg/kg.day) and acetylsalicylic acid in preventing the formation of coronary aneurysms. These recent advances in the understanding and treatment of Kawasaki disease may lead to a reappraisal of its diagnostic and prognostic criteria and open the way to multiple lines of research.

Aspirin↗
PubMed1989

[Neisseria meningitidis: serogroup Y. Apropos of 38 cases].

Thirty-eight cases of infections due to Neisseria meningitidis serogroup Y have been studied. They correspond to the strains sent to the Laboratory (Centre National de Référence since 1987). Their repartition was: meningitidis 9 cases, purpura fulminans (6), septicaemia (5), respiratory syndroms (11), asymptomatic carriage (4), various (3). Patients were 4 months to 86 years old. Mortality was 13.2%. One third or meningitis or meningococcemia happened in correlation with complement deficiency or splenectomy. In most of cases bacterial diagnosis was made by general laboratories but only in two cases over 38 the serogrouping Y was made.

Adolescent↗
PubMed1988

[Bilirubin-albumin-binding function of 2 human albumin preparations (placental and plasma). Comparison of their efficacy in the icteric premature infant].

Two albumin preparations obtained by Cohn fractionation of either plasma of blood donors (plasmatic albumin) or human placental blood (placental albumin) were studied in vitro and in vivo regarding their bilirubin-binding function. Analysis of this function during the industrial processing of the two preparations indicated that alcoholic fractionation and, to a lesser extent, stabilizers, were responsible for the decrease of (a) the association constants between albumin and bilirubin, (b) bilirubin-binding capacity of albumin. Unexpectedly, improvement of bilirubin-binding parameters was observed after the final heating stage. Stabilizers were reversibly bound as suggested by a further improvement of binding function seen after a brief contact of the preparations with red blood cells. The changes were similar for the two preparations. Fifty-one sick premature hyperbilirubinemic neonates were randomly infused either with placental or plasmatic albumin (1.5 g/kg). Albuminemia, bilirubinemia, erythrocytic bilirubin, unbound bilirubin (peroxidase method) were evaluated before and 3 hours after infusion. Improvement of bilirubin-binding parameters was frequently observed but without clear-cut relation with change in bilirubin/albumin molar ratio. No difference was noted between the two albumin preparations. In spite of a decrease of their association constants with bilirubin, the two albumins retained a high binding potency for bilirubin in vivo.

Bilirubin↗
PubMed1986

[Results of a national survey on the antibiotic therapy of neonatal bacterial infection due to materno-fetal contamination].

The aim of the study was to overview the antibiotic treatments usually prescribed in the different neonatal units and NICU's for neonatal primary bacterial infections. Maternal or neonatal fever, shock, respiratory distress, leuconeutropenia, hyperfibrinemia as well as an increased level in C-Reactive Protein appeared to be the best clinical diagnosis criteria. Before isolation of the bacteria, the most frequently prescribed treatment was a combination of ampicillin and gentamicin. When no bacteria grew up, the treatment was usually discontinued after a few days. When a presumably pathogenic bacteria was found either in blood, or CSF or urine or peripheral cultures, the treatment lasted around 10 days. However, in proved meningitis, the treatment lasted around 20 days. In case of Streptococcus type B and Listeria monocytogenes, ampicillin (100-200 mg/kg/day) was often used in combination with gentamicin (3-4 mg/kg/day), in spite of the recent availability of new aminoglycosides. When the isolated E. coli was ampicillin-resistant, Cefotaxime was frequently used in combination.

Anti-Bacterial Agents↗