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Biomedical subjects

A Bostrom

Publications and source records attributed to A Bostrom.

27 records · Page 2Linked to original sources
PubMed1994

Safety, activity, and pharmacokinetics of GLQ223 in patients with AIDS and AIDS-related complex.

GLQ223 is a highly purified single-chain ribosome-inactivating protein with selective effects against a variety of cells, including macrophages infected with human immunodeficiency virus. We evaluated the safety, pharmacokinetics, and immunologic effects of multiple doses of GLQ223 in 22 patients with AIDS or AIDS-related complex; CD4+ T-cell counts were between 100 and 350/mm3. GLQ223 was administered intravenously at doses of 8, 16, 24, 36, and 50 micrograms/kg of body weight; the drug was administered by constant infusion over 3 h to achieve a concentration in serum of 50 ng/ml; this concentration is known to be associated with anti-HIV effects in vitro. All patients reported a flu-like syndrome characterized by muscle and joint aches and an increase in creatinine kinase levels; symptoms were controlled easily. For patients who received 36 and 50 micrograms/kg, target concentrations in serum were achieved and an increase in CD4+ and CD8+ T cells was sustained; this sustained increase persisted for at least 28 days after the last infusion. beta 2-Microglobulin levels increased during the infusions and then declined when the infusions ended. Repeat infusions of GLQ223 were safe and relatively well tolerated. The target concentration of GLQ223 in serum was achieved and sustained. Our results suggest that GLQ223 may have activity in treating patients with human immunodeficiency virus infection.

AIDS-Related Complex↗
PubMed1990

Empirical indicators of near-term suicide risk.

In practice, clinicians estimating the likelihood of suicide are most concerned with short-term risk. To address this issue, an analysis of prospective data from 3,005 psychiatric patients at risk for suicide was carried out, focusing on 38 persons who committed suicide within 60 days of evaluation. Nine high-risk variables were identified: prior psychiatric hospitalization, contemplation of hanging or jumping, presence of suicidal impulses, divorced, a threat of financial loss, feeling a burden to others, unable to cry or severe crying, severe or moderate ideas of persecution or reference, and a negative or mixed reaction to the patient by the interviewer. Four or more of these characteristics identified the suicides with a sensitivity of 79% and a specificity of 81%.

Adolescent↗
PubMed1984

Adolescent motherhood. Comparison of outcome with older mothers.

The purpose of this study was to determine whether there were differences in maternal role attainment behaviors for three age groups (15-19, 20-29, 30-42 years) of 294 first-time mothers over a 1-year period. Interviews and questionnaires were completed at early postpartum, 1, 4, 8, and 12 months. Findings are in agreement with more recent research that the health status of adolescent mothers and their infants does not differ greatly from that of older mothers during the first year of motherhood. The adolescent's infant's growth and development were not handicapped. There were no group differences in feelings of love for the infant. The adolescent mother consistently scored lower than older mothers on observed and self-rated maternal competency behaviors. The adolescent mother derived greater gratification in the mothering role than older mothers through 8 months; at 12 months, the 20-29-year-old mother scored higher in gratification. The help received from the adolescent's mother declined at 8 and 12 months suggesting an increased need for social support from other sources at this time.

Adolescent↗
PubMed1984

Social support of teenage mothers.

The purpose of this paper is to report the social support perceived as available by teenage mothers during their first year of motherhood and the correlation of perceived social support with maternal role attainment variables. Social support was one of 11 independent variables studied for their impact on the maternal role for three age groups of first-time mothers: 15-19, 20-29, and 30-42 years. Social support described was categorized into four types--informational, emotional, physical, and appraisal--and by the network size. Sixty-six teenagers agreed to participate in the study, and they were interviewed in the hospital during early postpartum and in their homes or a setting of their choice at 1,4,8, and 12 months after birth. This highly mobile population was difficult to follow, and there was a subject loss over the year of 39.4% (N = 26). During early postpartum, the only type of support to correlate with maternal attachment (one of the two maternal role attainment variables measured at that time) was informational support, and teenagers had received significantly less than older women. There were no significant correlations of any of the support variables with the teenagers' perceptions of their neonate, the second measure of maternal role attainment. Teenagers received less emotional support from mates and from parents than older women. At 1 month postpartum, teenagers received less emotional support than older mothers, but reported more informational support. Support variables failed to correlate with maternal role attainment measures of perceptions of the neonate, ways of handling irritating child behaviors, or infants' growth and development. Physical and emotional support correlated positively with feelings of love for the infant, and informational and emotional support correlated positively with gratification in the mothering role. Physical support correlated positively with maternal competency behaviors. At 4 months after birth, teenagers continued to receive less emotional support than older mothers, but there were no differences in other types of support received. Physical support correlated positively with maternal gratification in the role, infants' growth and development, and maternal competency behaviors. Other types of support and the size of the network did not correlate with any of the maternal role attainment variables. Teenagers continued to receive less emotional support than older mothers at 8 months after birth, although there were no differences in other types of support received. The support variables failed to correlate significantly with any of the five maternal role attainment variables at this time.(ABSTRACT TRUNCATED AT 400 WORDS)

Adaptation, Psychological↗
PubMed1980

Gastrointestinal absorption of quinidine from some solutions and commercial tablets.

The gastrointestinal absorption of quinidine from three commercially available tablet products has been compared to that from a quinidine sulfate solution previously found to have 70% of the systematic availability of an intravenous dose. Quinidine gluconate solution was included in the study to compare the absorption characteristics of the two quinidine salts. The tablets were given in a counterbalanced sequence preceded by one quinidine solution and followed by the other in a crossover design. The three tablets proved to be equivalent to one another with respect to extent and rate of absorption. The absorption properties of the two solutions were indistinguishable. The tablets were equivalent to the solutions in extent but not in rate of absorption.

Adult↗
PubMedDate not supplied

The status of psychiatric nursing: characteristics and perceptions of nurses in the state of Michigan.

Concerned about the status of both mental health services and the role of professional nursing in the delivery of those services, the Michigan Nurses' Association Psychiatric-Mental Health Nursing Practice Section initiated a survey of psychiatric nurses in the state. One hundred forty psychiatric nurses returned questionnaires that explored their professional characteristics and activities, the characteristics of their clients, their perceptions of major issues confronting mental health services and psychiatric nursing and recommended actions, the perceived strengths of psychiatric nursing, and the skills and knowledge they believed are necessary for the future. Respondents are working with a variety of patients in difficult circumstances. Responses indicate the need for specialized knowledge and skills to provide care to mentally ill clients with increasingly complex problems, additional nursing involvement in political and health care arenas, and more nursing leadership and support within nursing.

Adult↗