[Small intestine endometriosis with lymph node involvement as a rare cause of acute abdomen].
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Abdomen, Acute↗
Biomedical subjects
A Bosse
Publications and source records attributed to A Bosse.
Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels.
Atherosclerotic vessels were analysed histochemically for distribution, quantity, and composition of apolipoprotein (Apo) types in the vascular wall. The specimens comprised all stages of atherosclerosis, from very discrete intimal changes to complicated lesions. The vessel specimens were marked with antibodies against human Apo A1, A2, and B. Apo A1 can be demonstrated in even the earliest stage of atherosclerosis, and increases with the progression of the disease. In the initial stage, Apo A1 is found first in lumen-adjacent layers of the intima, and is evident in deeper layers of the wall as the disease progresses. Arteries of muscular type show accumulation of Apo in an earlier stage (or in greater quantity at the same stage) than arteries of elastic type. At all stages, the amount of Apo A1 always exceeds that of A2 and B. In the intima, Apo B is higher than Apo A2, the media contains hardly any Apo B, and the adventitia has less B than A2. Within the intimal layer, Apo A1 and A2 are found in an intracellular (mainly in foam cells) or in an extracellular location, according to the stage of atherosclerosis. Apo B is almost exclusively extracellular; only cases of advanced atherosclerosis show some intracellular localization (mostly in foam cells), visualized as electron dense lamellar organelles, probably of lysosomal origin. In the media, Apo A1 and A2 are accumulated in intracellular deposits, whereas the extracellular storage of Apo A1, A2 and B is observed only in cases with the most severe damage. Our investigations suggest that the accumulation of apolipoproteins in the vascular wall is affected not only by insudation from the plasma, but also by neosynthesis and/or metabolism by locally derived cells or cells immigrating in the process of atherosclerosis. The presence of Apo A1 and A2 in the vessel wall is now documented, and their role at this site apparently differs from that in the plasma.
Aorta↗
Histogenesis of clear cell chondrosarcoma. An immunohistochemical study with osteonectin, a non-collagenous structure protein.
The histogenesis of clear cell chondrosarcoma is still unclear: Apart from typical clear cell tumor areas, extensive production of woven bone formation suggests within the clear cell cartilagenous stroma is an intriguing phenomenon. Three cases of clear cell chondrosarcoma documented in the Bone Tumor Registry of Westphalia were examined for their patterns of osteonectin expression, and compared with other bone tumors of either osseous or cartilaginous origin, and with normal cartilage tissue. Found predominantly in osseous structures, the protein osteonectin takes part in the formation of new bone. The three clear cell chondrosarcomas showed a strong immunoexpression of osteonectin in clear cell, chondroid and in osseous tumor areas. Similarly, evidence of osteonectin was also found in osteoblastic and in chondroblastic osteosarcomas as well as in osteoblastomas. In contrast, osteonectin could not be demonstrated in the chondrosarcomas and mesenchymal chondrosarcomas from our registry that were analysed for comparison, and was found only minimally in the fibroblastic areas of dedifferentiated chondrosarcomas. The chondroblastic tumor components were always negative. There was no immunoexpression of osteonectin either in fetal or adult intervertebral disc tissue. The present immunohistochemical study of osteonectin has distinctly separated clear cell chondrosarcoma from the other variants of chondrosarcoma, and aptly verified the specificity of this entity. Moreover, the study would call for further histogenetic evaluation of clear cell chondrosarcoma, since the pattern of osteonectin expression in that tumor seems to indicate an osteogenic rather than a chondrogenic origin.
Adenocarcinoma↗
Case report 669: Osteonecrosis of bone associated with intraarterial therapy using cisplatin.
A case is presented of an 18-year-old women who suffered pain and swelling after intraarterial cisplatin chemotherapy for osteosarcoma of the left fibula. Radiological studies showed minimal changes at the metadiaphyseal portion of the left tibia. Bone scans and MR studies were highly suggestive of necrosis of bone and muscle of the proximal end of the tibia. Multiple biopsies of the tibia at the time of excision and 2 years later showed histological features consistent with a slowly healing osteonecrosis of bone. Review of the literature reported transient pain and swelling after intraarterial chemotherapy but did not demonstrate the association with necrosis of bone and muscle. It can be anticipated that as intraarterial chemotherapy of malignant tumors of bone and soft tissues becomes more widely used, these complications will be observed more frequently.
Adolescent↗
Immunohistochemical double labeling of macrophages, smooth muscle cells, and apolipoprotein E in the atherosclerotic plaque.
To find out which cell types in the atherosclerotic plaque are actively involved in apolipoprotein-secretion, we stained tissue samples from the ascending aorta of patients undergoing coronary bypass surgery. We used monoclonal antibodies against macrophages, smooth muscle cells and apolipoprotein E. The present in situ-study of the atherosclerotic plaque has shown that apolipoprotein synthesis is predominantly secreted by macrophages transformed into foam cells. Besides this, there are obviously some smooth muscle cells equally transformed to foam cells, which also carry apolipoprotein E in their cytoplasm. Our data suggest that both cell types in the atherosclerotic plaque are actively involved in apolipoprotein secretion.
Apolipoproteins E↗
Apolipoproteins and immunohistological differentiation of cells in the arterial wall of kidneys in transplant arteriopathy. Morphological parallels with atherosclerosis.
22 nephrectomy specimens of renal allografts in chronic rejection after periods between 3 and 96 months, were studied immunohistologically. Various cell types in the arterial wall were characterized with antibodies specific against different cells of the mononuclear phagocyte system, against smooth muscle cells, and against differentiating lymphoid cells. In addition, the metabolism of lipoproteins was investigated using appropriate antibodies against several apolipoproteins. Subendothelial plaques of foam cells were found to consist of macrophages in foamy transformation. At the stage of intimal fibrosis the smooth muscle cells are more prominent. Lymphatic infiltration consists almost exclusively of T-lymphocytes. Apolipoprotein analysis reveals deposits of Apo A1, A2 and B1, most of them extracellular. According to these results, it is not only immunologic factors that are involved in arterial wall reactions during chronic transplant arteriopathy, but disorders of the lipoprotein metabolism--probably due to endothelial dysfunction--are also playing an important role like in atherosclerosis.
Adolescent↗
Juvenile intracortical adamantinoma of the tibia with predominant osteofibrous dysplasia-like features.
In view of the still disputed relationship between adult adamantinoma and osteofibrous dysplasia in children, a unique case of adamantinoma, indicating a direct relationship between the two lesions, is presented with a review of the literature. The patient was a six-year-old boy who complained of pain and swelling in the left lower leg. Roentgenographs showed a loculate osteolysis surrounded by sclerosis within the cortex of the tibial shaft that would be typical of osteofibrous dysplasia. Although an osteofibrous-dysplastic component predominated histologically, some small islands of epithelial cells were scattered throughout the lesion. Immunohistochemically, the tumor cells of these epithelial islands gave a constant positive reaction for cytokeratin as well as vimentin, while the stromal cells in the osteofibrous dysplasia-like lesion were positive for vimentin only. This type of lesion is recorded in the Bone Tumor Registry of Westphalia at a rate of 8.3% for osteofibrous dysplasia, and of 25% for adamantinoma. A review of the literature, yielding reports with remarkable uniformity on 14 cases beyond the present one, suggests the existence of a separate clinicopathologic entity to be called juvenile intracortical adamantinoma with predominant osteofibrous dysplasia-like features, and which might be a regressing form of adamantinoma specific in childhood.
Ameloblastoma↗
Eversion endarteriectomy of the internal carotid artery.
Eversion endarteriectomy has been proposed as a reliable and rapid method for operating on an ulcerated or stenosed internal carotid artery. The surgical technique is presented in detail. The perioperative course is appraised in a series of 60 operations. Irrespective of age and other diseases in the patients and the preoperative state of the ipsilateral and contralateral vessels, a perioperative morbidity of 1.6% (a temporary neurological deficit) and no lethal outcomes were found. Indication for operation on the carotid artery depends on the spontaneous prognosis based on the vascular morphology and the rate of perioperative complications. The method of surgery described establishes favorable conditions for endarteriectomy even in the asymptomatic stage as well as in exulcerative lesions of the carotid wall.
Carotid Artery, Internal↗
[The x-ray morphology of parosteal osteosarcoma (POS)].
31 cases of parosteal osteosarcoma (POS) including both the differentiated and dedifferentiated variant were reviewed. Most patients were in the second and third decades of life. The tumours usually arose in the meta-diaphyseal (52%) and diaphyseal (33%) portion of long bones with a predilection for the knee (55%). Twenty-seven percent of patients showed involvement of the medullary cavity. 68% of lesions affected the bone cortex. A periosteal reaction was observed in 24% of patients. The characteristic but not pathognomic sign of a fine radiolucent line separating the tumour from the cortex was seen in only 48%. No characteristic radiographic features were evident that allowed a differentiation between the differentiated and the dedifferentiated POS. The presence or absence of medullary involvement was no a reliable diagnostic criterion. In all dedifferentiated POS, however, we observed a periosteal reaction.
Adolescent↗
Rupture of the spleen caused by primary angiosarcoma. Case report.
Splenic angiosarcoma is rare with only about 60 reported cases. A case is presented in which the tumor caused spontaneous rupture of the spleen and showed characteristics of an infiltrating echinococcosis of the liver and spleen in ultrasound and computed tomography imaging. The literature is reviewed in regard to clinical features, diagnosis and management.
Diagnostic Errors↗
The impact of osteonectin for differential diagnosis of bone tumors. An immunohistochemical approach.
75 osteosarcoma at various grades of histologic differentiation, including chondroblastic and small cell variants, and 5 fibrosarcomas of bone, 5 Ewing's sarcomas, 5 malignant fibrous histiocytomas of bone, 8 chondrosarcomas, and 2 dedifferentiated chondrosarcomas, were investigated immunohistochemically for evidence of osteonectin. According to the results of our study, osteonectin is present in all osteosarcomas, with special topographic preponderance in the osteoblastic and chondroblastic variants. Evidence of osteonectin was also found in all other bone tumors we had analysed so far. In chondrosarcomas, positive reactions appeared only in the vicinity of trabeculae and in dedifferentiated areas. Thus, osteonectin cannot be regarded as a bone-specific protein. Although a high affinity for the osseous matrix is one of its undoubted features, it is therefore unsuitable for differential diagnostic purposes.
Bone Neoplasms↗
Response of osteosarcoma and Ewing sarcoma to preoperative chemotherapy: assessment with dynamic and static MR imaging and skeletal scintigraphy.
In 15 osteosarcomas and six Ewing sarcomas, response to preoperative chemotherapy was assessed with magnetic resonance (MR) imaging without and with gadolinium diethylenetriaminepentaacetic acid (DTPA) enhancement and with dynamic Gd-DTPA studies, and the results were compared with the scintigraphic findings. All studies were obtained prior to and following preoperative chemotherapy. Static MR imaging was of little value for assessment of response; reduction in signal intensity within soft-tissue masses on the T2-weighted spin-echo images indicated response with a sufficient degree of accuracy (71%) but low sensitivity, whereas an increase in signal intensity after Gd-DTPA administration indicated zones of viable tissue with low specificity. With three-phase skeletal scintigraphy, the findings in the perfusion and blood-pool phases were of no value, whereas the findings in the osseous phase allowed the prediction of response with an accuracy of 73.7%. Of all techniques employed, dynamic MR imaging had the highest degree of accuracy (85.7%) and was superior to scintigraphy, particularly in patients who were receiving intraarterial chemotherapy.
Adolescent↗
[Generalization of Crohn disease].
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Aged↗
[The diagnosis of functional epigastric syndrome].
The radiological examination of the stomach and the duodenum under functional aspects resulted in references of an irritative stomach in patients with epigastric complaints without conceivable organic findings lasting for many years. On the basis of simultaneously established peculiarities in the behaviour and the social situation of the patients concerned the disturbance of kinetics demonstrated is realized with great probability and explained as pathological by the patient. The results of the examination may be points of influence for the therapy of such disturbances.
Adult↗
Immunohistochemical investigation of chordomas: histogenetic and differential diagnostic aspects.
Chordomas are rare tumors of neuroectodermal origin and often show a very heterogeneous histological picture. In a combined histochemical and immunohistochemical study of 32 chordomas collected in the Bone Tumor Registry of Westphalia we were able to show that the immunoreactivity of the cells in both chordoma and notochordal structures are in close relationship with the extracellular matrix and depends more on the metabolic activity of these cells than on the origin of the cells of the neuroectoderm. All tumor cells show a bimodal immunoreaction with cytokeratin and vimentin, as well as a strong immunoreaction with the oncofetal markers CEA and AFP. The differentiation of chordomas from other malignant tumors, mainly the myxoid variant of chondrosarcoma, may cause major difficulties, especially if only a little biopsy material is available. Here we can see that in tumors with bimodal immunoexpression of vimentin and cytokeratin, as can be found in chordomas, the further use of antibodies offers a reliable differential diagnostic tool. The positive reaction of chordomas with all epithelial tumor markers offers a clear differentiation from chondrosarcomas, which, unlike chordomas, do not express cytokeratin. The identification of a marker profile by employing common antisera is of major value in the differentiation of chordoma from other epithelial or mesenchymal tumors.
Adult↗
[Immunohistological differentiation of the cells of the arterial wall in transplanted kidneys].
22 nephrectomy specimens of renal allografts in chronic rejection after 3 months to 96 months were studied immunohistologically. The various cell types in the arterial wall were characterised with specific antibodies against different cells of the mononuclear phagocyte system, against smooth muscle cells, and for differentiating lymphatic cells. In addition, the metabolism of lipoproteins was studied using different antibodies against several apolipoproteins. According to our results, subendothelial plaques of foam cells consist of macrophages in foamy transformation. In the stage of intimal fibrosis, smooth muscle cells are more prominent. Lymphatic infiltration consists almost exclusively of T lymphocytes. Apolipoprotein analysis reveals deposits of Apolipoproteins A1 and B, mostly extracellular. On the whole, these results show that not only immunologic factors are involved in the reaction of the arterial wall in chronic transplant arteriopathy, but that like in atherosclerosis, disorders of lipoprotein metabolism, probably due to endothelial dysfunction, play an important role.
Desmin↗
[Duplex sonography in the diagnosis of venous thromboses following kidney transplantation].
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Adult↗
[Adrenal gland hemangioma--a case report].
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Adrenal Gland Neoplasms↗