Hemorrhagic shock was experimentally induced in 40 mongrel dogs, and the resulting pulmonary vascular resistances studied. A mechanical test with closure of the left branch of the pulmonary artery and two pharmacological tests with isoproterenol (isuprel) and cyclic adenosine-monophosphate (cAMP) were performed. The results suggest that there is a block in the beta-control during prolonged shock, and that beta-control is restored by cAMP.

Animals↗

PubMedDate not supplied

Preoperative treatment of hydatid cysts with mebendazole.

Mebendazole--an anthelmintic drug which is known to have a lethal effect on hydatid cysts--was administered preoperatively to patients affected by Echinococciasis, in order to sterilize cysts and prevent surgical contamination. Our results suggest that mebendazole treatment (1500 mg/die for 25 days) was effective in ten out of eleven cases; no major toxic effect was observed.

Benzimidazoles↗