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Biomedical subjects

A Bondoli

Publications and source records attributed to A Bondoli.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Identification of drugs in toxic doses in biological fluids using infrared Spectrophotometry].

A method permitting rapid analysis of biological samples from patients suspected of being intoxicated is reported. The method is based on: a) extraction of the active principles of biological samples with chloroform; b) drying and preparation of a disc of KBr; c) spectrophotometric analysis; d) integration of data from laboratory analyses with the clinical data from the patient. A number of clinical cases are also reported in which adoption of the method permitted rapid diagnosis of the possible aetiology of the toxic pictures observed.

Body Fluids↗
PubMed1980

Biochemical changes in neurosurgical patients under critical care treated with mannitol.

A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and in an increase of discriminate osmolality (to 60 mosM/kg H2O). A hypothesis about the particular biochemical mechanism, involving the electrolyte and water distribution, is presented.

Acid-Base Equilibrium↗
PubMed1980

An attempt to control cerebrospinal fluid acidosis in coma due to head injury.

The acid-base status of the arterial blood, jugular venous blood, peripheral venous blood and lumbar cerebrospinal fluid and the free amino acids in the cerebrospinal fluid have been studied in 12 patients suffering from coma due to head injury. They were given S adenosyl-methionine (10 mg/kg/day). Significant statistical differences of acid-base balance and CSF free amino acids have been obtained after the administration of te compound. The clinical and biochemical significance of the use of S adenosyl-methionine in severe brain injuries is discussed

Amino Acids↗
PubMed1980

Lysine hydrochloride for the control of metabolic alkalosis: a clinical report.

Many physiopathological states can produce metabolic alkalosis that must be promptly corrected as soon as it is dangerous. In our study we report the effectiveness of lysine hydrochloride to correct this condition in patients. This drug lowers the pH, reduces the bicarbonate stores, and leads to normal blood gases.

Acid-Base Imbalance↗
PubMed1979

Rheological and biochemical changes in open heart surgery with extracorporeal circulation and moderate hypothermia.

The plasma enzymes, glucose, urea nitrogen, total and conjugated bilirubin, osmolality, acid--base balance and rheological data have been studied in a group of patients who underwent open heart surgery to replace the stenotic or insufficient aortic valve. The aim of this study was to assess our operative conditions and to compare results with those obtained by other authors.

Acid-Base Equilibrium↗
PubMed1979

The significane of measurement of osmolality in critically ill patients.

The plasma and urine osmolality and their ratios were measured in 774 patients in critical care. We found that changes in osmolality were related to the alterations of ratios of sodium ion, glucose, blood urea nitrogen and unknown metabolites, and this knowledge may be of therapeutic and prognostic value.

Acute Kidney Injury↗
PubMed1979

Distribution of free amino acids in coma due to acute barbiturate poisoning in guinea pigs.

The cerebral protein and amino acid concentrations in guinea pigs coma due to barbiturate poisoning have been studies. Some significant alterations in systemic and central amino acid patterns have been found, giving rise to a hypothesis about the biochemical pathways involved in the coma. An attempt to correlate the amino acid changes and cerebral energetic 'need' is also reported.

Amino Acids↗
PubMed1979

Effect of respiratory acidosis on plasma and CSF free amino acids.

Acid-base data and levels of selected cerebrospinal fluid (CSF) free amino acids were analyzed in a series of 8 patients in acute respiratory failure. In these patients, there were increased CSF concentrations of methionine, phenylalanine, tyrosine, histidine, alpha-amino-N-butyric acid, glutamic acid, glutamine, glycine, alanine, and ammonia, while arginine decreased. Phenylalanine, tryosine, and alanine were correlated with CSF PCO2; and alpha-amino-N-butyric acid to the buffer capacity of CO2 and pH. The data suggest the hypothesis that there are two metabolic phases for ammonia removal from brain tissue, that could explain some of these pathhophysiological conditions.

Acidosis, Respiratory↗
PubMed1978

Intravenous sodium lactate administration in respiratory alkalosis secondary to severe brain injuries.

In acute cerebrovascular accidents the uptake of lactate by the brain tissue is enhanced, possibly in an attempt to buffer the increased local lactic acidosis. In this paper the results obtained by the administration of the lactate in 78 cases of hyperventilatory syndromes secondary to acute brain injuries, and the biochemistry of the cerebrospinal fluid and blood, are reported.

Acid-Base Equilibrium↗