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Biomedical subjects

A Bondi

Publications and source records attributed to A Bondi.

At least 55 records · Page 3Linked to original sources
PubMed1984

Neoplastic cells containing lysozyme in gastric carcinomas.

A case of gastric carcinoma mostly composed of cells with histological, immunohistochemical and ultrastructural features of Paneth cells prompted a comparative investigation of the occurrence of similar cells in gastric, colorectal and mammary carcinomas. Cells containing lysozyme were demonstrated by the immunoperoxidase-PAP technique in 34.9% of 83 gastric carcinomas. They were found in 38% of intestinal-type and in 30% of diffuse-type tumours. Paneth-type granules were demonstrated ultrastructurally in 4 of 7 carcinomas in which lysozyme had been demonstrated immunohistochemically. No lysozyme was demonstrated in a series of 30 breast carcinomas and in only 1 of 27 cases of colorectal neoplasm. The possibility of using lysozyme as a marker for some carcinomas of gastric origin is considered.

Adult↗
PubMed1984

Morpho-functional changes in normal cyclic endometrium.

Eight cases of normal endometrium in the early proliferative phase and an equal number of cases in the late secretive phase were stained histochemically for acidic mucosubstances and immunocytochemically for epithelial membrane antigen (EMA), carcinoembryogenetic antigen (CEA) and Gross Cyst Disease Fluid Protein -15 (GCDFP-15) production. Alcian blue positive material was observed in both phases of the cycle, although the distribution was different. Sulphated mucosubstances were only present in the secretive phase. No CEA nor GCDFP-15 immunoreactive material was detected. EMA positive staining was observed in all cases, but the distribution varied according to the two different phases of the cycle.

Adult↗
PubMed1984

Vitamin A and carotene in animal nutrition.

Vitamin A, an unsaturated 20 carbon cyclic alcohol, subserves a number of important physiological functions. However, the biochemical basis of these roles is not well understood. The main sources of retinol are liver, egg yolk and milk fat. Several carotenoids show vitamin A activity. The conversion of beta-carotene to retinol is affected by copper-containing dioxygenase and zinc-containing retinene reductase. The efficiency of conversion varies in different species. The latter is defined in units as the daily dose required to produce a weight gain of 3 g/week in young rats between the 4th and 8th week. Retinol is unstable on exposure to light or heat, particularly in the presence of heavy metal ions and water. Much recent work has focused on the absorption, metabolism and excretion of vitamin A. It is now recognized that plasma vitamin A levels do not reflect the nutritional status except in severe hypo- and hypervitaminosis A. Also, many dietary factors may influence vitamin A metabolism. These basic and applied aspects of vitamin A are reviewed.

Absorption↗
PubMed1984

Simultaneous polypoid tumors of the stomach and duodenum with composite cell population (mucous, argyrophil, and lysozyme-containing cells): a case report.

Seventeen years after a Billroth II gastric resection for duodenal ulcer had been performed, two large polypoid tumors were found in the gastric stump (outside the stomal area) and in the duodenal stump of a 69-year-old man. Histologically the neoplasms were tubular adenomas with small focal carcinomatous changes restricted to the gastric tumor. A distinctive feature of both tumors was the occurrence of three major cell populations segregated into two different types of neoplastic epithelium: one with columnar mucous cells containing gastric type mucins and mixed with a large number of argyrophil endocrine cells and the other with large, pleomorphic cells containing immunoreactive lysozyme and intestinal type mucins. In the absence of any evidence of generalized gastrointestinal polyposes, it is suggested that both tumors originated from the gastric mucosa (of heterotopic origin in the duodenum) and that the second type epithelium may represent a particular, and up to now unrecognized, type of intestinal metaplasia.

Aged↗
PubMed1983

Strumal carcinoid of the ovary: an immunohistochemical and electron microscopic study.

A case of strumal carcinoid of the ovary is reported. The follicles contained T4-immunoreactive substance, whereas the carcinoid component of the tumor had a trabecular structure and showed argyrophilic elements. Pancreatic-polypeptide and enteroglucagon were localized in these cells by an immunocytochemical method. The same cells displayed small electron-dense endocrine-like granules. A common precursor for the thyroid and carcinoid components is postulated.

Carcinoid Tumor↗
PubMed1983

Occurrence of different types of contractile cells in some lung fibrosis.

Two different morphologic patterns of pulmonary fibrosis have been identified by means of anti-actin antisera and electron microscopy. The first type, observed in chronic passive congestion and also in radiation-induced fibrosis, is characterized by hyaline alveolar walls, with scarce cells, mostly normal fibroblasts. The second type, on the contrary, shows a high cellularity of the alveolar walls with actin-rich cell proliferation, i.e. contractile interstitial cells in usual interstitial pneumonia and shock lung, myofibroblasts in organizing pneumonia, and smooth muscle cells in honeycomb lungs.

Adult↗
PubMed1981

Oat cell carcinoma of the esophagus. Report of a case.

A case of primary oat cell carcinoma of the esophagus is described. The oat cell pattern appeared intermingled with small areas of squamous carcinoma. The origin of this mixed tumor is discussed together with the literature on esophageal carcinomas with an oat cell pattern.

Carcinoma, Small Cell↗
PubMed1981

Endocrine-paracrine cells in pancreatic exocrine carcinomas.

Eleven cases of primary pancreatic adenocarcinomas have been investigated histochemically, immunohistochemically and with electron-microscopy. Endocrine-paracrine (EP) cells were present in six of these tumours. In one case numerous 5HT-enterochromaffin cells (EC) of the intestinal type and a few somatostatin immunoreactive D cells were found. Two cases contained insulin-immunoreactive cells and another case displayed glucagon-IR elements. In the remaining two cases argyrophilic cells were present. These findings demonstrate that polypeptide hormone or amine production is not restricted to islet cell tumours. It is suggested that both endocrine and exocrine components of the tumours studied might have derived from a common precursor.

Adenocarcinoma↗
PubMed1980

Retrospective studies of early gastric cancer in a high incidence area of Italy.

Frequency and characteristics of early gastric cancer (egc) were evaluated in a retrospective study of 511 surgical specimens of gastric carcinoma. We observed a total of 46 egc in 40 patients. The predominant macroscopic type was IIc, followed by I and III. On the basis of histological appearance, 25 egc were of intestinal type and 15 of diffuse type. Seventy-six per cent of egc were localized at the lesser curvature of the stomach and in particular at the pyloric antrum. Twenty-two egc were limited to the muscosal layer. no relationship was observed between macroscopic type or histological characters, and tumour staging. As Italy can be considered a high-risk country for gastric carcinoma and because this disease is in many respects similar to that observed in Japan, it seems possible to obtain a reduction of the death rate for gastric cancer by increasing, as in Japan, the number of cancers diagnosed in the early phase.

Adult↗
PubMed1980

DNA microspectrophotometric study in smear preparations from paraffin embedded tissue.

A DNA microspectrofluorimetric study on smears from cells detached from paraffin embedded tissue is presented. The cellular DNA values of these smears were compared with the cellular DNA values of fresh imprints and paraffin embedded sections obtained from the same tissue. The histograms were similar for fresh imprints and paraffin embedded smears while the DNA values in the sections were notably different. This method appears very suitable for retrospective studies of DNA using microspectrofluorimetry in routine histopathology.

DNA↗
PubMed1976

The ileum of the sheep as a site of protein digestion.

1. In order to study the ability of the ileum of the sheep to digest and absorb protein, casein or gluten were infused into the intestine of rams through cannulas inserted at distances of 0-05, 7, 9 and 15 m from the pylorus. Amounts of casein or gluten containing 10-20 g nitrogen were infused during 24 h, in animals given a low-N diet. 2. N balance was negative during the preliminary period when no infusion was given; infusion of casein or gluten increased the daily N retention to 5-15 g. 3. Infusion of proteins into the intestine did not induce an increased activity of pancreatic proteases in digesta withdrawn from the lower part of the intestine. 4. The increased N retention after the infusion of proteins into the lower part of the intestine indicates a considerable capacity of this section of the intestine to digest and absorb proteins.

Animals↗