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Biomedical subjects

A Bondi

Publications and source records attributed to A Bondi.

At least 19 recordsLinked to original sources
PubMed1990

Primary malignant lymphoma of sciatic nerve. Report of a case.

A 72-year-old man with a 2-year history of motor-sensory neuropathy of the right foot was found to have a lymphoma involving a 50-cm length of the sciatic nerve. This occurred in the absence of any other evidence of disease by detailed clinical staging. The lymphoma was of large follicular center-cell type. The cells strongly expressed a B-cell marker detected by the 4KB5 monoclonal antibody and selectively infiltrated the nerve bundles, dissociating preexisting myelin-producing Schwann cells and axons. This is the second report of similar localization. Primary selective involvement of a nerve is a rare mechanism of peripheral neuropathy in lymphoproliferative disorders, to be added to systemic dissemination of lymphomas and leukemias, direct spread of an adjacent tumor, and immunologically mediated disease.

Aged↗
PubMed1987

Anti-nutritive factors in animal feedstuffs and their effects on livestock.

This review deals with compounds -mainly organic-which when present in the diet, may affect the health of livestock or interfere with normal feed utilization. The anti-nutrients occur as natural constituents of plants and animal feeds, as artificial factors added during processing, or as contaminants of the ecosystem. Their mode of action, metabolism in the living body, and detoxification mechanisms, are described briefly. It is stressed that ruminants and monogastric species frequently differ in susceptibility to the same toxicant, mainly due to the action of rumen microorganisms. The toxicants described are classified as follows: proteins depressing digestion (protease inhibitors and lectins); glucosides; phenolic substances; other toxicants occurring in plants; substances interfering with the utilization of vitamins; mycotoxins; pesticides and industrial chemicals.

Animal Feed↗
PubMed1985

Amphicrine--composite calcitonin and mucin-producing--carcinoma of the thyroid.

A case of thyroid carcinoma in a 38-year-old male with a high serum level of calcitonin is reported. The tumor was composed of polygonal argyrophilic cells, signet ring Alcian blue-positive cells, and a minority of amphicrine elements. The same polymorphic cellular component was seen at the ultrastructural level. Anticalcitonin immunoperoxidase revealed that the majority of cells were positive, including the amphicrine cells. In spite of calcitonin production it is felt that cases similar to the present one should be distinguished from "ordinary medullary" carcinoma and the terms "amphicrine" or "composite calcitonin and mucin-producing carcinoma" are proposed.

Adult↗
PubMed1984

Morphofunctional findings in adenocarcinoma of endometrium.

Ten cases of adenocarcinoma of the endometrium were studied using histochemical methods for mucopolysaccharides and immunocytochemical methods for the localization of various markers, such as EMA (epithelial membrane antigen), GCDFP-15 (gross cystic disease fluid protein) and CEA. Four cases appeared to contain High Iron Diamine-positive substance and 6 cases were positive using an immunocytochemical method with a polyclonal anti-CEA antiserum. In contrast, no cases stained when a monoclonal anti-CEA antiserum was employed. This suggested that HID- positive material could be a sign of differentiation towards cells with a secretory function.

Adenocarcinoma↗
PubMed1984

Immunohistochemical localization of myoglobin in nonmuscular cells.

Myoglobin has been detected by the immunoperoxidase technique in the cytoplasm of nonmuscular cells present in malignant tumors infiltrating skeletal muscle. The positive cells were reactive histiocytes in one case, and malignant cells (breast carcinoma, malignant melanoma, and malignant lymphoma) in the others. These findings indicate the need to exercise caution in the interpretation of myoglobin stain for the diagnosis of rhabdomyosarcoma under these circumstances.

Breast Neoplasms↗
PubMed1984

Squamous cell carcinoma with sarcoma-like stroma of the nose and paranasal sinuses: report of two cases.

Two cases of squamous cell carcinoma with sarcoma-like stroma of the nose and paranasal sinuses are described. To the best of our knowledge, this is the first report of such a localization for this tumour type. Keratin was localized by immunocytochemistry in the epithelial cells, as well as in occasional stromal-like elements. The importance of distinguishing these tumours from morphologically similar neoplasms is emphasized in view of their different therapeutic approach.

Aged↗
PubMed1984

'True' sarcomatoid carcinoma of the renal pelvis. First case report with immunocytochemical study.

A case of sarcomatoid carcinoma of the renal pelvis is reported. The neoplasm showed polypoid configuration and was composed exclusively of plump, spindle and pleomorphic cells. Light microscopy did not reveal any epithelial differentiation of the neoplastic cells. Immunoperoxidase staining for keratins and for epithelial membrane antigen was strongly positive in the spindle elements and showed the epithelial nature of the proliferation. The present case suggests that pleomorphic tumors, when occurring in visceral organs, should be carefully sampled and immunocytochemical markers for epithelial and sarcomatous differentiation studied, before diagnosis of carcinosarcoma or sarcoma may be accepted.

Carcinosarcoma↗
PubMed1984

Neoplastic cells containing lysozyme in gastric carcinomas.

A case of gastric carcinoma mostly composed of cells with histological, immunohistochemical and ultrastructural features of Paneth cells prompted a comparative investigation of the occurrence of similar cells in gastric, colorectal and mammary carcinomas. Cells containing lysozyme were demonstrated by the immunoperoxidase-PAP technique in 34.9% of 83 gastric carcinomas. They were found in 38% of intestinal-type and in 30% of diffuse-type tumours. Paneth-type granules were demonstrated ultrastructurally in 4 of 7 carcinomas in which lysozyme had been demonstrated immunohistochemically. No lysozyme was demonstrated in a series of 30 breast carcinomas and in only 1 of 27 cases of colorectal neoplasm. The possibility of using lysozyme as a marker for some carcinomas of gastric origin is considered.

Adult↗
PubMed1984

Morpho-functional changes in normal cyclic endometrium.

Eight cases of normal endometrium in the early proliferative phase and an equal number of cases in the late secretive phase were stained histochemically for acidic mucosubstances and immunocytochemically for epithelial membrane antigen (EMA), carcinoembryogenetic antigen (CEA) and Gross Cyst Disease Fluid Protein -15 (GCDFP-15) production. Alcian blue positive material was observed in both phases of the cycle, although the distribution was different. Sulphated mucosubstances were only present in the secretive phase. No CEA nor GCDFP-15 immunoreactive material was detected. EMA positive staining was observed in all cases, but the distribution varied according to the two different phases of the cycle.

Adult↗
PubMed1984

Vitamin A and carotene in animal nutrition.

Vitamin A, an unsaturated 20 carbon cyclic alcohol, subserves a number of important physiological functions. However, the biochemical basis of these roles is not well understood. The main sources of retinol are liver, egg yolk and milk fat. Several carotenoids show vitamin A activity. The conversion of beta-carotene to retinol is affected by copper-containing dioxygenase and zinc-containing retinene reductase. The efficiency of conversion varies in different species. The latter is defined in units as the daily dose required to produce a weight gain of 3 g/week in young rats between the 4th and 8th week. Retinol is unstable on exposure to light or heat, particularly in the presence of heavy metal ions and water. Much recent work has focused on the absorption, metabolism and excretion of vitamin A. It is now recognized that plasma vitamin A levels do not reflect the nutritional status except in severe hypo- and hypervitaminosis A. Also, many dietary factors may influence vitamin A metabolism. These basic and applied aspects of vitamin A are reviewed.

Absorption↗
PubMed1984

Simultaneous polypoid tumors of the stomach and duodenum with composite cell population (mucous, argyrophil, and lysozyme-containing cells): a case report.

Seventeen years after a Billroth II gastric resection for duodenal ulcer had been performed, two large polypoid tumors were found in the gastric stump (outside the stomal area) and in the duodenal stump of a 69-year-old man. Histologically the neoplasms were tubular adenomas with small focal carcinomatous changes restricted to the gastric tumor. A distinctive feature of both tumors was the occurrence of three major cell populations segregated into two different types of neoplastic epithelium: one with columnar mucous cells containing gastric type mucins and mixed with a large number of argyrophil endocrine cells and the other with large, pleomorphic cells containing immunoreactive lysozyme and intestinal type mucins. In the absence of any evidence of generalized gastrointestinal polyposes, it is suggested that both tumors originated from the gastric mucosa (of heterotopic origin in the duodenum) and that the second type epithelium may represent a particular, and up to now unrecognized, type of intestinal metaplasia.

Aged↗
PubMed1983

Strumal carcinoid of the ovary: an immunohistochemical and electron microscopic study.

A case of strumal carcinoid of the ovary is reported. The follicles contained T4-immunoreactive substance, whereas the carcinoid component of the tumor had a trabecular structure and showed argyrophilic elements. Pancreatic-polypeptide and enteroglucagon were localized in these cells by an immunocytochemical method. The same cells displayed small electron-dense endocrine-like granules. A common precursor for the thyroid and carcinoid components is postulated.

Carcinoid Tumor↗
PubMed1983

Occurrence of different types of contractile cells in some lung fibrosis.

Two different morphologic patterns of pulmonary fibrosis have been identified by means of anti-actin antisera and electron microscopy. The first type, observed in chronic passive congestion and also in radiation-induced fibrosis, is characterized by hyaline alveolar walls, with scarce cells, mostly normal fibroblasts. The second type, on the contrary, shows a high cellularity of the alveolar walls with actin-rich cell proliferation, i.e. contractile interstitial cells in usual interstitial pneumonia and shock lung, myofibroblasts in organizing pneumonia, and smooth muscle cells in honeycomb lungs.

Adult↗
PubMed1981

Oat cell carcinoma of the esophagus. Report of a case.

A case of primary oat cell carcinoma of the esophagus is described. The oat cell pattern appeared intermingled with small areas of squamous carcinoma. The origin of this mixed tumor is discussed together with the literature on esophageal carcinomas with an oat cell pattern.

Carcinoma, Small Cell↗
PubMed1981

Endocrine-paracrine cells in pancreatic exocrine carcinomas.

Eleven cases of primary pancreatic adenocarcinomas have been investigated histochemically, immunohistochemically and with electron-microscopy. Endocrine-paracrine (EP) cells were present in six of these tumours. In one case numerous 5HT-enterochromaffin cells (EC) of the intestinal type and a few somatostatin immunoreactive D cells were found. Two cases contained insulin-immunoreactive cells and another case displayed glucagon-IR elements. In the remaining two cases argyrophilic cells were present. These findings demonstrate that polypeptide hormone or amine production is not restricted to islet cell tumours. It is suggested that both endocrine and exocrine components of the tumours studied might have derived from a common precursor.

Adenocarcinoma↗