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Biomedical subjects

A Bolte

Publications and source records attributed to A Bolte.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)].

In 37 pregnancy women preterm labour was inhibited with intravenous administration of ASA. 20 patients (Group I) had a combined treatment of ASA and Fenoterol. 7 pregnant women (Group II) without successful labour inhibition under Fenoterol were treated with ASA subsequently. In a third group of 10 women we administered ASA alone. The treatment was considered as successful if signs of preterm labour stopped and pregnancy maintained for 7 days or more. In the first group 16, in the second group all patients had been treated successfully. In group III we succeeded in labour inhibiting for more than 7 days in 6 cases. An initial loading dose of 5.5 to 7.0 mn/min ASA had been infused for 24 hours. If preterm labour was stopped, the dosage had been reduced. In all patients dose related but reversible symptoms of vertigo, tinnitus, headache and hyperventilation were seen. Furthermore we found a non-dose-dependent prolongation ( by 30% or normal) of bleeding time. In the fetus respectively the newborn an affection by this ASA treatment could be excluded. We propose inhibition of preterm labour by i.v. ASA administration in all pregnant women if beta-mimetic drugs are not successful or an intolerance is diagnosed. Contraindications for ASA therapy are mentioned.

Aspirin↗
PubMed1980

[Dosage related effect of fenoterol on fetal hemoglobin oxygen affinity (author's transl)].

Fenoterol induced displacements of the fetal oxygen dissociation curve were investigated in animal experiments by determining the oxygen halfsaturation pressure (P 50). At term pregnant rabbits were infused intravenously over 3 hours with an increasing Fenoterol dosis (10 to 30 microgram/kg/min) up to a dosis level which produced complete labour inhibition. By cesarean section fetal aortic blood was collected and the oxygen halfsaturation pressure (P 50) was determined as described by Lichtman et al. (14). All P 50 values were corrected to so-called standard conditions (pH: 7.4; PCO2: 40 mmHg; t: 37 degrees C). Likewise, in a second series P 50 values were measured in newborn rabbits which received Fenoterol subcutaneously as a single shot injection. In the first series standardized P 50 significantly fell from 20.9 to 15.0 mmHg and in the second series it fell from 20.9 to 14.4 mmHg. This raised oxygen hemoglobin affinity, i.e. leftward shift of the fetal oxygen dissociation curve, is probably due to a Fenoterol induced diminution of the red cell 2.3-DPG concentration. In all cases of severe fetal hypoxia a beneficial effect on O2-transport is discussed whereas at normoxia or mild hypoxia a rightward shift of the oxygen dissociation curve would be more favourable.

Animals↗
PubMed1979

[Examinations on the pathomechanism of severe cardio-pulmonary hazards under i.v. tocolytic treatment with beta-adrenergic drugs (author's transl)].

Lungs edemas in five pregnant women under i.v. tocolytic treatment with betaadrenergic drugs between the 28.--33. week of gestation are reported. Additionally, in all cases Betamethasone was given to prevent fetal lungs dysmaturity. Within less than 72 hours the occurrence of lungs edema was observed when both drugs were given simultaneously. These findings are in agreement with those of other authors, who observed similar symptoms in as well clinically healthy pregnant women under the same therapy. As the underlying pathomechanism the coincidence of the following factors are discussed: 1. An increased pressure in the pulmonary circulatory system as found in current, not yet published heart catheter investigations. 2. A reduced colloidosmotic pressure caused by Beta-methasone.

Adrenergic beta-Agonists↗
PubMed1979

[Prenatal diagnosis of triploidy (69, XXX) (author's transl)].

By amniocentesis we succeeded in finding a case of triploidy (69,XXX). Because of an extreme fetal dystrophy and missing fetal movements in the 33rd week a severe malformation was suspected. The clinical, ultrasonographical, cytogenetital, hormonal and autopsy findings are reported and discussed.

Adult↗
PubMed1978

[External cephalic version in the management of breech presentation near to term (author's transl)].

External cephalic version was tried in 58 from 146 cases of breech presentation after the 36th week of gestation and was successful in 55 per cent. The incidence of breech delivery was reduced from 5.3 to 4.2 per cent. With increasing weeks of gestation there was no rise in the failure rate. External version was more successful in multiparas than in primigravidas and in patients with high or low weight than in patients with normal weight and a thick muscular abdominal wall. The most frequent causes of failed versions were a thick muscular abdominal wall, extended legs and an already fixed breech in the pelvic inlet. 76 per cent of the deliveries took place within 10 days after the attempt of version. The weight of the newborns was except one over 2500 g, the average weight after successful version was 3250 g and after failed version 2930 g. Different severe fetal complications were seen after failed version but none when the attempt had been successful. On account of our own examinations and a critical analysis of the literature we came to the result that external cephalic version near to term should only be done after careful taken indication with a very precautioned technique, a thorough obstetrical examination, hospitalization and delivery shortly after.

Abdominal Muscles↗
PubMed1978

[The significance of prenatal diagnosis of twins (author's transl)].

By means of ultrasound and fetal electrocardiography the diagnosis of twin pregnancies can be made prenatally without any reservation; the diagnosis is even possible in the first half of pregnancy. Comparative analysis of two approximately equal collectives of in all 602 twin pregnancies--1,45% of all births in the years 1955-1975 at the University Clinic for Gynecology and Obstetrics of the University of Cologne--revealed a better prognosis concerning the course of pregnancy and the new-born by prenatal diagnosis. The earliest possible diagnosis of twins, resulting in more intense clinical observation--and occasional clinical treatment--facilitated a significantly longer duration of pregnancy, leading to a higher percentage of mature twins. Whereas the total number of obstetric operations was reduced because of prenatal diagnosis, selection of highrisk cases led to a distinct increase in Caesarian sections. The prolongation of pregnancy, the higher birth weights and better maturity attained, were accompanied by decrease in perinatal mortality and in improvement in the Apgar-index of the newborn in that collective, in which prenatal diagnosis was achieved.

Apgar Score↗
PubMed1978

[Fetal and placental maturation processes towards the end of pregnancy and their diagnosis (author's transl)].

Prenatal fetal maturation is defined as the sum of all growth and differentiation processes necessary for a mature, eutrophic newborn capable of further independent development. These growth and maturation processes, which can be precisely assessed in animal experiments, are subject to genetic and teratogenic influences, but are mainly determined by the duration of pregnancy and uteroplacental function. With the diagnositc procedures available today, such as somography and fetal electrocardiography, the growth and differentiation processes mainly depending on the duration of pregnancy may be assessed from early gestation until term; in cases with discrepancy between duration and normal maturation, the time of birth may be advanced or postponed, and in cases with insufficient growth analyses of steroid and protein hormones permit conclusions as to disturbed uteroplacental function.

Birth Weight↗