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Biomedical subjects

A Bollinger

Publications and source records attributed to A Bollinger.

At least 199 records · Page 11Linked to original sources

Blood pressure fluctuations in human nailfold capillaries.

Dynamic blood pressure was measured in 33 human finger nailfold capillaries after direct cannulation with glass micropipettes by means of a resistance servo-nulling pressure measuring method. ECG, finger pulsations, and respiratory thorax excursions were monitored simultaneously. All recordings exhibited pulsatile oscillations related to the cardiac rhythm. These oscillations resembled the wave forms of arterial pulsations with steep upstroke and dicrotic notch when the pressure amplitudes were above 10 mmHg. There was no apparent dependence on respiration. In 12 instances, pressure fluctuations with frequencies ranging from 0.2 down to 0.07 Hz were observed in both the arteriolar and venular limb. Blood pressure in human skin capillaries is pulsatile and subject to remarkable fluctuations in the arteriolar as well as in the venular limb, systolic pressure values ranging from 14 to 71 mmHg and from 11 to 52 mmHg, respectively.

Adult↗

[The arteriographic appearances of the hypothenar hammer syndrome (author's transl)].

The characteristic angiographic appearances found in the superficial palmar arch are described in five cases of the hypothenar hammer syndrome. The symptoms depend on the anatomical peculiarities of the arteries in the hand, the extent of the causative lesion and the condition of the peripheral digital arteries. The condition is probably more common than is thought. It can be differentiated from other vascular abnormalities of the hand by angiography.

Adult↗

Angiosarcoma of the superficial femoral artery with distal embolization.

Angiosarcoma of the intima is a very rare tumor. The authors report a case which involved early metastases to the periphery of the leg. Cramping pain, circumscribed clusters of cells, and gangrene appear to be characteristic and should be kept in mind, as this condition imitates occlusive arteriosclerotic disease.

Aged↗

Changes in phasic femoral artery flow induced by various stimuli: a study with percutaneous pulsed Doppler ultrasound.

Transcutaneous blood flow measurements were performed by means of pulsed Doppler ultrasound flowmeter in the femoral artery of healthy subjects. The pulsatile flow pattern was changed characteristically from resting state by postocclusive reactive hyperaemia, by the application of amyl nitrite, xanthinol nicotinate, and angiotensin amide. During reactive hyperaemia systolic flow was increased, diastolic reverse flow was abolished, and the forward flow continued throughout diastole. Amyl nitrite augmented thenegative flow phase and reduced mean flow, while xanthinol nicotinate decreased the negative component and augmented mean flow. Angiotensin amide produced enhancement of the average flow by elevating systolic and diastolic flow equally over the base line. In each of these interventions the changes in flow were determined mainly by variations during the diastolic flow phase.

Adult↗

[The role of the costo-clavicular compression syndrome within the framework of fibrinolytic therapy of deep arm-vein thrombosis].

Eight patients with upper extremity deep-vein thrombosis were treated with thrombolytic agents. The role of a compression syndrome of the costo-clavicular space (found in 5 out of 7 cases) as a probably thrombogenetic factor is discussed. The complications of the therapy were considerable, despite frequent laboratory controls. In one thrombosis of more than 6 months' standing the treatment was ineffective. In the other 7 cases the early clinical results were good. At follow-up 14 to 57 months after thrombolytic therapy, 5 out of 7 cases had residual symptoms (rethrombosis in 2 cases). This may be due to the fact that the compression syndrome was not initially treated, with resultant persistence of the chronic trauma to the vein. Better results can be expected from fibrinolytic therapy in combination with surgical correction of any anatomical narrowing.

Adult↗

[Primary and secondary Raynaud's syndrome].

In the light of practical considerations a distinction is necessary between vasospastic and occlusive disease of hand and finger arteries. The vasospastic condition is usually termed Raynaud's disease and leads to recurrent ischemic attacks affecting the fingers, with early onset in life. In most instances, organic occlusions of peripheral arteries develop without initial vasospastic symptoms (exception: patients with collagen vascular disorders). Measurements of finger blood flow reported in this review show that vasospastic Raynaud's disease may be considered a variant of physiologic flow behavior in young women. Only in severe cases do cold stimuli precipitate long-lasting periods of non-measurable finger flow (venous occlusion plethysmography with finger strain gauges). In 109 personal observations the possible etiologic factors involved in organic finger artery occlusions are analyzed. They include a broad spectrum (arteriosclerosis obliterans, endangitis obliterans, collagen vascular disease, thrombocytosis, chronic occupational trauma, cryoglobulinemia). Therapy is directed at the underlying disease and the specific situation. In cases with severe ischemic symptoms, sympathectomy, intraarterial injections of reserpine, and treatment with Ancrod or fibrinolytic agents should be considered.

Adult↗

Measurement of foot artery blood pressure by micromanometry in normal subjects and in patients with arterial occlusive disease.

Blood pressure was measured continuously in the posterior tibial or dorsalis pedis arteries using an isovolumetric system (steel cannulas of 0.18 mm, external diameter). The systolic values in the ankle arteries of 13 normal subjects at rest (154.3 +/- 22.3 mm Hg) exceeded the systolic arm pressure (128.9 +/- 20.1 mm Hg, P less than 0.001), while diastolic values (69.9 +/- 8.7 mm Hg) were not significantly different from the arm pressure. In 13 patients with arterial occlusive disease (AOD) the dicrotic notch, normally situated close to the footpoint of the downslope, was either displaced upward or abolished. Both mean systolic and diastolic values (94.9 +/- 35.9 mm Hg and 62.5 +/- 18.5 mm Hg, respectively) and also mean pressure amplitude were reduced compared to the corresponding arm values (158.5 +/- 28.2 mm Hg and 87.7 +/- 6.0 mm Hg, respectively, all P less than 0.001). Comparison between the systolic pressure values measured by micromanometry and by an indirect technique using Doppler ultrasound showed a good correlation (r = 0.87). During postocclusive reactive hyperemia, the initial pressure values were markedly diminished in normal subjects and reached control values within 40 sec. In patients with AOD, however, this reduction in pressure was more pronounced and prolonged. Flow measurements using plethysmography showed flow diversion from the foot to the calf as long as pressure values ranged below 40 mm Hg. This almost painless method appears useful for experimental and diagnostic studies in low pressure areas of the peripheral circulation.

Adult↗

Finger blood flow in healthy subjects of different age and sex and in patients with primary Raynaud's disease.

Finger blood flow measured at rest and after 3 minutes of circulatory arrest by strain gauge venous occlusion plethysmography was significantly higher (p less than 0.001) in a group of 13 healthy young men than in a group of 12 healthy young women. The flow values in 13 women in the meopause reached almost the level found in men. Hormonal factors might explain these differences. Between the group of the healthy young women and the 12 patients with Raynaud's disease there were only gradual differences in finger blood flow. Peak flow after 3 minutes of circulatory arrest was significantly lower in the patients (p less than 0.05). Whereas flow at rest showed only a tendency to lower values (mean room temperature 24 degrees C). The spontaneous and cold induced vasopastic attacks characterized by a decrease in finger volume and by very low or not measurable finger flow.

Adult↗